Selenbp2 selenium binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Selenbp2provided by MGI
Official Full Name: selenium binding protein 2provided by MGI
Primary source: MGI:MGI:104859
See related: Ensembl:ENSMUSG00000068877 AllianceGenome:MGI:104859
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AP56; Lpsb2
Summary: Predicted to enable selenium binding activity. Predicted to act upstream of or within protein transport. Predicted to be located in fibrillar center. Is expressed in epithelium; liver; and lung. Orthologous to human SELENBP1 (selenium binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 168.1), lung adult (RPKM 119.9) and 15 other tissues See more
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Genomic context

Location:: 3 F2.1; 3 40.74 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (94600880..94611713)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (94693573..94704406)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

it was shown that the observed differences in SBP2 abundance correlate with sex differences in transcription of the gene encoding SBP2, selenbp2, as revealed by RT-PCR and restriction digest as well as sequence analysis of the products.
Title: Selenium-binding protein 2, the major hepatic target for acetaminophen, shows sex differences in protein abundance.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Selenbp1 (e-PCR), detects polymorphism
- UniSTS:144390

Selenbp1 (e-PCR), detects polymorphism
- UniSTS:144391

Selenbp1 (e-PCR), detects polymorphism
- UniSTS:144392

32.MMHAP10FC5.seq (e-PCR)
- UniSTS:123973

M32032 (e-PCR)
- UniSTS:178874

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables methanethiol oxidase activity	ISO Inferred from Sequence Orthology more info
enables selenium binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: selenium-binding protein 2

Names: 56 kDa acetaminophen-binding protein; acetaminophen-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.