Esr2 estrogen receptor 2 (beta) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esr2provided by MGI
Official Full Name: estrogen receptor 2 (beta)provided by MGI
Primary source: MGI:MGI:109392
See related: Ensembl:ENSMUSG00000021055 AllianceGenome:MGI:109392
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ER[b]; Estrb; ERbeta
Summary: Enables DNA binding activity. Acts upstream of or within several processes, including hormone-mediated signaling pathway; nervous system development; and reproductive structure development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart mesentery; limb segment; and mammary gland primordium. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); hypospadias; neurodegenerative disease (multiple); and ovarian dysgenesis 8. Orthologous to human ESR2 (estrogen receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 17.0), lung adult (RPKM 1.1) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 33.52 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (76167193..76224033, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (76120419..76177259, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of ERbeta Disrupts Gene Regulation in Primordial and Primary Follicles.
Title: Loss of ERβ Disrupts Gene Regulation in Primordial and Primary Follicles.
AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERbeta.
Title: AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERβ.
Estrogen Receptor beta in the Lateral Septum Mediates Estrogen Regulation of Social Anxiety-like Behavior in Male Mice.
Title: Estrogen Receptor β in the Lateral Septum Mediates Estrogen Regulation of Social Anxiety-like Behavior in Male Mice.
Ovarian ERbeta cistrome and transcriptome reveal chromatin interaction with LRH-1.
Title: Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1.
Loss of ERbeta in Aging LXRalphabeta Knockout Mice Leads to Colitis.
Title: Loss of ERβ in Aging LXRαβ Knockout Mice Leads to Colitis.
ERbeta promoted invadopodia formation-mediated non-small cell lung cancer metastasis via the ICAM1/p-Src/p-Cortactin signaling pathway.
Title: ERβ promoted invadopodia formation-mediated non-small cell lung cancer metastasis via the ICAM1/p-Src/p-Cortactin signaling pathway.
Metabolic benefits of 17alpha-estradiol in liver are partially mediated by ERbeta in male mice.
Title: Metabolic benefits of 17α-estradiol in liver are partially mediated by ERβ in male mice.
Estrogen receptor beta attenuates renal fibrosis by suppressing the transcriptional activity of Smad3.
Title: Estrogen receptor β attenuates renal fibrosis by suppressing the transcriptional activity of Smad3.
Membrane Estrogen Receptor beta Is Sufficient to Mitigate Cardiac Cell Pathology.
Title: Membrane Estrogen Receptor β Is Sufficient to Mitigate Cardiac Cell Pathology.
Osteocyte Estrogen Receptor beta (Ot-ERbeta) Regulates Bone Turnover and Skeletal Adaptive Response to Mechanical Loading Differently in Male and Female Growing and Adult Mice.
Title: Osteocyte Estrogen Receptor β (Ot-ERβ) Regulates Bone Turnover and Skeletal Adaptive Response to Mechanical Loading Differently in Male and Female Growing and Adult Mice.

Submit: New GeneRIF Correction See all GeneRIFs (302)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (15) 1 citation
Endonuclease-mediated (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Esr2 (e-PCR), detects polymorphism
- UniSTS:256862

D12Mit286 (e-PCR), detects polymorphism
- UniSTS:126845

Esr2 (e-PCR), detects polymorphism
- UniSTS:257224

Esr2 (e-PCR), detects polymorphism
- UniSTS:257225

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables estradiol binding	ISO Inferred from Sequence Orthology more info
enables estrogen binding	ISO Inferred from Sequence Orthology more info
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables estrogen response element binding	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear steroid receptor activity	ISO Inferred from Sequence Orthology more info
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISO Inferred from Sequence Orthology more info
enables steroid hormone binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Sertoli cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral fear response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estrogen stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell maturation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrous cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hormone-mediated apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular estrogen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland epithelium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to testosterone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within uterus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vagina development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: estrogen receptor beta

Names: ER-beta; nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010157.3 → NP_034287.3 estrogen receptor beta isoform 2

See identical proteins and their annotated locations for NP_034287.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK054413

Consensus CDS

CCDS25987.1

UniProtKB/Swiss-Prot

B2RUC6, E9QKX7, O08537, O35635, O70519, Q8BG65, Q91Z86

UniProtKB/TrEMBL

A0A0R4J0Y6

Related

ENSMUSP00000075932.5, ENSMUST00000076634.5

Conserved Domains (3) summary

cd06949
Location:282 → 517

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:163 → 244

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam12497
Location:35 → 141

ERbeta_N; Estrogen receptor beta
NM_207707.1 → NP_997590.1 estrogen receptor beta isoform 1

See identical proteins and their annotated locations for NP_997590.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK054413

Consensus CDS

CCDS25988.1

UniProtKB/Swiss-Prot

B2RUC6, E9QKX7, O08537, O35635, O70519, Q8BG65, Q91Z86

UniProtKB/TrEMBL

A0A1W2P736

Related

ENSMUSP00000151463.2, ENSMUST00000218621.2

Conserved Domains (3) summary

cd06949
Location:282 → 535

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:163 → 244

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam12497
Location:35 → 141

ERbeta_N; Estrogen receptor beta

RNA

NR_104386.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK054301, AK054413

Related

ENSMUST00000133564.9