Kynu kynureninase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kynuprovided by RGD
Official Full Name: kynureninaseprovided by RGD
Primary source: RGD:71061
See related: Ensembl:ENSRNOG00000029993 AllianceGenome:RGD:71061
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables kynureninase activity and pyridoxal phosphate binding activity. Involved in aging and tryptophan catabolic process to acetyl-CoA. Located in cytosol. Used to study hypertension. Human ortholog(s) of this gene implicated in hydroxykynureninuria. Orthologous to human KYNU (kynureninase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 931.1) and Kidney (RPKM 250.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (48188286..48338996)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (27778646..27929470)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (28416926..28566939)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats.
Title: Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats.
Kynurenine aminotransferase is expressed in the neurons of the transient subplate zone during prenatal development of the cerebral cortex and may play a role in regulating programmed neuronal cell death.
Title: Expression of kynurenine aminotransferase in the subplate of the rat and its possible role in the regulation of programmed cell death.
Spontaneously hypertensive rats have a missense mutation in KAT-1
Title: A missense mutation in kynurenine aminotransferase-1 in spontaneously hypertensive rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-hydroxykynureninase activity	ISO Inferred from Sequence Orthology more info
enables 3-hydroxykynureninase activity	ISS Inferred from Sequence or Structural Similarity more info
enables kynureninase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kynureninase activity	IDA Inferred from Direct Assay more info	PubMed
enables kynureninase activity	IEA Inferred from Electronic Annotation more info
enables kynureninase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan	IEA Inferred from Electronic Annotation more info
involved_in L-kynurenine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in NAD biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in NAD biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in anthranilate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anthranilate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in anthranilate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in quinolinate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in quinolinate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin B6	ISO Inferred from Sequence Orthology more info
involved_in tryptophan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in tryptophan catabolic process to acetyl-CoA	IDA Inferred from Direct Assay more info	PubMed
involved_in tryptophan catabolic process to kynurenine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kynureninase

Names: L-kynurenine hydrolase

NP_446354.1

EC 3.7.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053902.2 → NP_446354.1 kynureninase

See identical proteins and their annotated locations for NP_446354.1

Status: PROVISIONAL

Source sequence(s)

U68168

UniProtKB/Swiss-Prot

P70712, Q68G25, Q7M0D0, Q9QW90

Related

ENSRNOP00000050947.4, ENSRNOT00000043533.5

Conserved Domains (2) summary

TIGR01814
Location:30 → 459

kynureninase; kynureninase

cl18945
Location:24 → 462

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...