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    ZNF660-ZNF197 ZNF660-ZNF197 readthrough [ Homo sapiens (human) ]

    Gene ID: 110354863, updated on 15-Mar-2024

    Summary

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    Gene symbol
    ZNF660-ZNF197
    Gene description
    ZNF660-ZNF197 readthrough
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene represents naturally-occurring readthrough transcription between the adjacent zinc finger protein 660 (ZNF660) and zinc finger protein 197 (ZNF197) genes. Readthrough transcripts may encode proteins similar to the proteins encoded by ZNF197. [provided by RefSeq, May 2017]
    Orthologs
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    Genomic context

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    Location:
    3p21.31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44584964..44648471)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44600686..44664179)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44626456..44689963)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 852 pseudogene Neighboring gene Sharpr-MPRA regulatory region 15293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44598251-44598752 Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene zinc finger with KRAB and SCAN domains 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44622134-44622634 Neighboring gene myosin phosphatase Rho interacting protein pseudogene 1 Neighboring gene zinc finger protein 660 Neighboring gene ZNF197 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44666861-44667363 Neighboring gene zinc finger protein 197 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44689909-44690468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19768 Neighboring gene zinc finger protein 35 Neighboring gene zinc finger protein 251 pseudogene Neighboring gene zinc finger protein OZF-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19769

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. Pengue G, et al. Hum Mol Genet, 1993 Jun. PMID 8353497
    2. Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. Gonsky R, et al. Nucleic Acids Res, 1997 Oct 1. PMID 9380504, Free PMC Article
    3. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. Li Z, et al. EMBO J, 2003 Apr 15. PMID 12682018, Free PMC Article
    4. The DNA sequence, annotation and analysis of human chromosome 3. Muzny DM, et al. Nature, 2006 Apr 27. PMID 16641997
    5. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    Genotypes

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 197
    Names
    pVHL-associated KRAB domain-containing protein
    zinc finger protein with KRAB and SCAN domains 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351732.2 → NP_001338661.1  zinc finger protein 197 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC099669
      UniProtKB/Swiss-Prot
      B2RAH8, O14709, Q86VG0
      Conserved Domains (5) summary
      smart00431
      Location:38 → 150
      SCAN; leucine rich region
      COG5048
      Location:424 → 853
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:400 → 420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:216 → 256
      KRAB; KRAB box
      pfam13465
      Location:384 → 409
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001351733.2 → NP_001338662.1  zinc finger protein 197 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC099669
      UniProtKB/Swiss-Prot
      B2RAH8, O14709, Q86VG0
      Conserved Domains (5) summary
      smart00431
      Location:38 → 150
      SCAN; leucine rich region
      COG5048
      Location:424 → 853
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:400 → 420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:216 → 256
      KRAB; KRAB box
      pfam13465
      Location:384 → 409
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001351734.2 → NP_001338663.1  zinc finger protein 197 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC099669
      Conserved Domains (2) summary
      smart00431
      Location:38 → 150
      SCAN; leucine rich region
      pfam01352
      Location:216 → 257
      KRAB; KRAB box

    4. NM_001351735.2 → NP_001338664.1  zinc finger protein 197 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC099669
      Conserved Domains (2) summary
      smart00431
      Location:38 → 150
      SCAN; leucine rich region
      pfam01352
      Location:216 → 257
      KRAB; KRAB box

    RNA

    1. NR_147691.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC099669

    2. NR_147692.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC099669

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      44584964..44648471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646197.1 Reference GRCh38.p14 PATCHES

      Range
      110318..173825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      44600686..44664179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14709.1 GenPept UniProtKB/Swiss-Prot:O14709

    Gene LinkOut

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    Molecular Biology Databases