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    Dut deoxyuridine triphosphatase [ Mus musculus (house mouse) ]

    Gene ID: 110074, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dutprovided by MGI
    Official Full Name
    deoxyuridine triphosphataseprovided by MGI
    Primary source
    MGI:MGI:1346051
    See related
    Ensembl:ENSMUSG00000027203 AllianceGenome:MGI:1346051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dutp; dUTPase; D2Bwg0749e; 5031412I06Rik; 5133400F09Rik
    Summary
    Predicted to enable several functions, including dUTP diphosphatase activity; magnesium ion binding activity; and peroxisome proliferator activated receptor binding activity. Predicted to be involved in pyrimidine deoxyribonucleotide metabolic process and regulation of protein-containing complex assembly. Located in mitochondrion. Is expressed in central nervous system and retina. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 32.2), liver E14 (RPKM 31.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F1; 2 61.33 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125089168..125100969)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125247248..125259049)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 1 Neighboring gene predicted gene, 46760 Neighboring gene predicted gene 14002 Neighboring gene STARR-seq mESC enhancer starr_05586 Neighboring gene STARR-positive B cell enhancer mm9_chr2:125073047-125073348 Neighboring gene STARR-seq mESC enhancer starr_05587 Neighboring gene STARR-seq mESC enhancer starr_05588 Neighboring gene fibrillin 1 Neighboring gene STARR-seq mESC enhancer starr_05589 Neighboring gene centrosomal protein 152 Neighboring gene 60S ribosomal protein L27 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality. Pálinkás HL, et al. Biomolecules, 2019 Apr 4. PMID 30987342, Free PMC Article
    2. Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition. Koehler SE, et al. Mol Pharmacol, 2004 Sep. PMID 15322254
    3. Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331. Webley SD, et al. Br J Cancer, 2000 Sep. PMID 10952785, Free PMC Article
    4. Cloning and expression of the mouse deoxyuridine triphosphate nucleotidohydrolase gene: differs from the rat enzyme in that it lacks nuclear receptor interacting LXXLL motif. Kan L, et al. Gene Expr, 1999. PMID 10794525, Free PMC Article
    5. Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase. Ladner RD, et al. J Biol Chem, 1996 Mar 29. PMID 8631816

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dUTPase is essential for embryonic development since early dut -/- embryos die shortly after implantation. dut +/- animals are viable while having decreased dUTPase levels.
      Title: CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality.
    2. Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.
      Title: Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dUTP diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyrimidine deoxyribonucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dTMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in dUMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dUTP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    deoxyuridine 5'-triphosphate nucleotidohydrolase
    Names
    deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
    NP_001153118.1
    NP_076084.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159646.1 → NP_001153118.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 1

      See identical proteins and their annotated locations for NP_001153118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK135438, AK153285
      Consensus CDS
      CCDS50695.1
      UniProtKB/TrEMBL
      Q8VCG1, Q9CQ43
      Related
      ENSMUSP00000080767.8, ENSMUST00000082122.14
      Conserved Domains (1) summary
      cl00493
      Location:61 → 198
      trimeric_dUTPase; Trimeric dUTP diphosphatases

    2. NM_023595.6 → NP_076084.2  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2

      See identical proteins and their annotated locations for NP_076084.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK077244, AK153285
      Consensus CDS
      CCDS16675.1
      UniProtKB/Swiss-Prot
      Q8VCG1, Q9CQ43, Q9JJ44
      Related
      ENSMUSP00000057854.9, ENSMUST00000051605.9
      Conserved Domains (1) summary
      cl00493
      Location:23 → 160
      trimeric_dUTPase; Trimeric dUTP diphosphatases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      125089168..125100969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ43.1 GenPept UniProtKB/Swiss-Prot:Q9CQ43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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