CYLD CYLD lysine 63 deubiquitinase [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CYLDprovided by VGNC
Official Full Name: CYLD lysine 63 deubiquitinaseprovided by VGNC
Primary source: VGNC:VGNC:50293
See related: Ensembl:ENSCAFG00845003806
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (65106294..65174257, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (61134885..61201742, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (63838510..63905381, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (61931223..61997967, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (62949929..63017871, complement)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables K63-linked deubiquitinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in necroptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein K63-linked deubiquitination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase CYLD; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD

XP_005617624.1

EC 3.1.2.15

XP_005617625.1

EC 3.1.2.15

XP_005617626.1

EC 3.1.2.15

XP_038317097.1

EC 3.1.2.15

XP_038317101.1

EC 3.1.2.15

XP_038326170.1

EC 3.1.2.15

XP_038386995.1

EC 3.1.2.15

XP_038451210.1

EC 3.1.2.15

XP_038451211.1

EC 3.1.2.15

XP_038451212.1

EC 3.1.2.15

XP_038451213.1

EC 3.1.2.15

XP_038451215.1

EC 3.1.2.15

XP_038451216.1

EC 3.1.2.15

XP_038515298.1

EC 3.1.2.15

XP_038515299.1

EC 3.1.2.15

XP_038515300.1

EC 3.1.2.15

XP_038515301.1

EC 3.1.2.15

XP_038515302.1

EC 3.1.2.15

XP_038515303.1

EC 3.1.2.15

XP_854436.1

EC 3.1.2.15

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051806.1 Reference ROS_Cfam_1.0

Range

65106294..65174257 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038659371.1 → XP_038515299.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8C0RFJ2, A0A8C0YXA7, A0A8I3MSL4

Conserved Domains (3) summary

smart01052
Location:472 → 540

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:593 → 948

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 471

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038659375.1 → XP_038515303.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

Conserved Domains (3) summary

smart01052
Location:250 → 318

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:371 → 726

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:85 → 249

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038659374.1 → XP_038515302.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

Conserved Domains (3) summary

smart01052
Location:250 → 318

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:371 → 726

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:85 → 249

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038659373.1 → XP_038515301.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

UniProtKB/TrEMBL

A0A8I3MLC9, A0A8I3MLG1, A0A8P0P0W3, A0A8P0P4S9

Related

ENSCAFP00845005500.1, ENSCAFT00845006905.1

Conserved Domains (3) summary

smart01052
Location:397 → 465

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:518 → 873

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:305 → 396

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038659372.1 → XP_038515300.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/TrEMBL

A0A8C0SG81

Related

ENSCAFP00845005505.1, ENSCAFT00845006911.1

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038659370.1 → XP_038515298.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8C0RFJ2, A0A8C0YXA7, A0A8I3MSL4

Related

ENSCAFP00845005437.1, ENSCAFT00845006826.1

Conserved Domains (3) summary

smart01052
Location:472 → 540

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:593 → 948

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 471

CYLD_phos_site; Phosphorylation region of CYLD, unstructured

Alternate UMICH_Zoey_3.1

Genomic

NC_049262.1 Alternate UMICH_Zoey_3.1

Range

61931223..61997967 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038470242.1 → XP_038326170.1 LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049743.1 Alternate UNSW_CanFamBas_1.0

Range

62949929..63017871 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038595283.1 → XP_038451211.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

Conserved Domains (3) summary

smart01052
Location:472 → 540

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:593 → 948

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 471

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038595288.1 → XP_038451216.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

Conserved Domains (3) summary

smart01052
Location:250 → 318

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:371 → 726

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:85 → 249

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038595287.1 → XP_038451215.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

Conserved Domains (3) summary

smart01052
Location:250 → 318

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:371 → 726

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:85 → 249

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038595285.1 → XP_038451213.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

Conserved Domains (3) summary

smart01052
Location:397 → 465

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:518 → 873

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:305 → 396

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038595284.1 → XP_038451212.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038595282.1 → XP_038451210.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

Conserved Domains (3) summary

smart01052
Location:472 → 540

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:593 → 948

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 471

CYLD_phos_site; Phosphorylation region of CYLD, unstructured

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049223.1 Alternate UU_Cfam_GSD_1.0

Range

63838510..63905381 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038531067.1 → XP_038386995.1 LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8C0YXA7

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

61134885..61201742 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005617567.4 → XP_005617624.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

See identical proteins and their annotated locations for XP_005617624.1

UniProtKB/TrEMBL

A0A8C0RFJ2, A0A8C0YXA7, A0A8I3MSL4

Conserved Domains (3) summary

smart01052
Location:472 → 540

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:593 → 948

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 471

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038461173.1 → XP_038317101.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

Conserved Domains (3) summary

smart01052
Location:250 → 318

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:371 → 726

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:85 → 249

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_038461169.1 → XP_038317097.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

Conserved Domains (3) summary

smart01052
Location:250 → 318

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:371 → 726

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:85 → 249

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_005617569.4 → XP_005617626.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

UniProtKB/TrEMBL

A0A8I3MLC9, A0A8I3MLG1, A0A8P0P0W3, A0A8P0P4S9

Conserved Domains (3) summary

smart01052
Location:397 → 465

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:518 → 873

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:305 → 396

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_005617568.4 → XP_005617625.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/TrEMBL

A0A8C0SG81

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_849343.6 → XP_854436.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

See identical proteins and their annotated locations for XP_854436.1

UniProtKB/TrEMBL

A0A8C0RFJ2, A0A8C0YXA7, A0A8I3MSL4

Conserved Domains (3) summary

smart01052
Location:472 → 540

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:593 → 948

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 471

CYLD_phos_site; Phosphorylation region of CYLD, unstructured