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1: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 [ Homo sapiens ]

GeneID: 4300 updated 20-Dec-2009

[Top][Help]Summary

Official Symbol
MLLT3provided by HGNC
Official Full Name
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3provided by HGNC
Primary Source
HGNC:7136
See related
Ensembl:ENSG00000171843; HPRD:01163; MIM:159558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AF9; YEATS3; FLJ2035; MLLT3

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 9; Location: 9p22See MLLT3 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. Diversin, containing several nuclear localization signals, translocates to the nucleus, where it interacts with the transcription factor AF9.
PubMed 2. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: MLL/AF9.
PubMed 3. In the Acute Myeloid Leukemia patients, detected MLL rearrangements consisting of MLL/AF6, MLL/AF9, MLL/AF17 , MLL/ELL and MLL partial tandem duplication. MLL rearrangement include chromosome translocation and partial tandem duplication.
PubMed 4. MLLT3 as a regulator of early erythroid and megakaryocytic cell fate in the human system.
PubMed 5. Expression of MLL-AF9 in human CD34+ cells induces acute myeloid, lymphoid, or mixed-lineage leukemia in immunodeficient mice.
PubMed 6. demonstrate coimmunoprecipitation of the All1/Af4 and All1/Af9 fusions with Drosha, disrupted by treatment with DNase I
PubMed 7. Down-regulation of AF9 is not necessary to abolish malignant phenotypes by induction of terminal monocyte-macrophage differentiation in leukaemic cells carrying t(9;11)(p22;q23).
Submit: New GeneRIF Correction

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  P42568   P51825   AFF1      HPRD    PubMed
 
  P42568   Q92624   APPBP2      HPRD    PubMed
 
  P42568   Q6W2J9   BCOR      HPRD    PubMed
 
  P42568   Q5T3J3   C1orf103      HPRD    PubMed
 
  P42568   Hypothetical protein DKFZp564O0523   C7orf64      HPRD    PubMed
 
  P42568   Q9HC52   CBX8      HPRD    PubMed
 
  P42568   P68104   EEF1A1      HPRD    PubMed
 
  P42568   Q14566   MCM6      HPRD    PubMed
 
  P42568   P42568   MLLT3      HPRD    PubMed
 
  P42568   P21246   PTN      HPRD    PubMed
Two-hybrid
  BioGRID:110446   BioGRID:115769   APPBP2      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:110446   BioGRID:120228   BCOR      BioGRID    PubMed
Two-hybrid
  BioGRID:110446   BioGRID:120905   C1orf103      BioGRID    PubMed
Two-hybrid
  BioGRID:110446   BioGRID:123855   C7orf64      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:110446   BioGRID:124082   DOT1L      BioGRID    PubMed
Two-hybrid
  BioGRID:110446   BioGRID:108237   EEF1A1      BioGRID    PubMed
Two-hybrid
  BioGRID:110446   BioGRID:110343   MCM6      BioGRID    PubMed
Two-hybrid
  BioGRID:110446   BioGRID:111731   PTN      BioGRID    PubMed
Biochemical Activity
  BioGRID:110446   BioGRID:112344   SGK1      BioGRID    PubMed

[Top][Help]General gene information

Markers

SHGC-83267(e-PCR)
Links: UniSTS:101148
BE111905(e-PCR)
Links: UniSTS:245811
D9S1778(e-PCR), detects polymorphism
Links: UniSTS:16194
RH11443(e-PCR)
Links: UniSTS:69187
G15985(e-PCR)
Links: UniSTS:47687
MLLT3__6320(e-PCR)
Links: UniSTS:471671
SHGC-53630(e-PCR)
Links: UniSTS:34192
D9S1886(e-PCR)
Links: UniSTS:57746
RH120095(e-PCR)
Links: UniSTS:132300
GDB:373748(e-PCR)
Links: UniSTS:156927

Homology

Homologs of the MLLT3 gene The MLLT3 gene is conserved in chimpanzee, dog, cow, mouse, chicken, and zebrafish.


Map Viewer (Mouse)

Gene Ontology Provided by GOA

Function Evidence
protein binding IEA   
Component Evidence
cytoplasm IDA PubMed
nucleus IDA PubMed

[Top][Help]General protein information

Preferred Names
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
Names
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_004529.2 → NP_004520.2  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

    Source sequence(s)
    BC036089,BX649194,L13744
    Consensus CDS
    CCDS6494.1
    UniProtKB/Swiss-Prot
    P42568
    UniProtKB/TrEMBL
    Q6MZE2
    UniProtKB/TrEMBL
    Q8IVB0
    Related Ensembl
    ENSP00000369695, ENST00000380338
    Conserved Domains (1) summary
    cl02094
    Location:29 – 112
    Blast Score: 286
    YEATS; YEATS family

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000009.11

    Range
    20344967..20622513, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_008413.18 

    Range
    20334967..20612513, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000052.1

    Range
    20283495..20561026, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_924062.1 

    Range
    20168014..20445545, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000141.1

    Range
    20307852..20585160
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001839149.2 

    Range
    15283060..15560368
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AL163193.5  (56286..175930)   None
  genomic   AL354879.12   CAI14771.1
  genomic   AL512635.8   CAH70705.1
       CAH70706.1
       CAH70707.1
  genomic   AL513498.2  (29126..155779)   None
  genomic   AL627410.9  (2000..4600)   None
  genomic   CH471071.2   EAW58630.1
       EAW58631.1
       EAW58632.1
  mRNA   AK225957.1   None
  mRNA   AK297587.1   BAH12621.1
  mRNA   AK301474.1   BAH13491.1
  mRNA   AK312914.1   BAG35760.1
  mRNA   BC030550.1   None
  mRNA   BC036089.1   AAH36089.1
  mRNA   BX649194.1   CAE46213.1
  mRNA   D16688.1   BAA04090.1
  mRNA   L13744.1   AAA58361.1
Protein Accession   Links
P42568.2   GenPept   UniProtKB/Swiss-Prot:P42568
Q6LEQ8   GenPept   UniProtKB/TrEMBL:Q6LEQ8
Q6MZE2   GenPept   UniProtKB/TrEMBL:Q6MZE2
Q8IVB0   GenPept   UniProtKB/TrEMBL:Q8IVB0

[Top][Help]Additional Links

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