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    pnp-1 Purine nucleoside phosphorylase [ Caenorhabditis elegans ]

    Gene ID: 176851, updated on 23-Nov-2023

    Summary

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    Gene symbol
    pnp-1
    Gene description
    Purine nucleoside phosphorylase
    Primary source
    WormBase:WBGene00019298
    Locus tag
    CELE_K02D7.1
    See related
    AllianceGenome:WB:WBGene00019298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable purine-nucleoside phosphorylase activity. Involved in innate immune response. Predicted to be active in cytoplasm. Is expressed in intestine. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (292433..298280, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene Sugar transporter SWEET1 Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity. Martell J, et al. Cell Chem Biol, 2016 Aug 18. PMID 27499530, Free PMC Article
    2. Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection. Olaitan AO, et al. PLoS Genet, 2018 Sep. PMID 30265660, Free PMC Article
    3. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine-nucleoside phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-nucleoside phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Purine nucleoside phosphorylase
    NP_001368342.1
    • Confirmed by transcript evidence
    NP_001379888.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      292433..298280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392243.1 → NP_001379888.1  Purine nucleoside phosphorylase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61217
      Conserved Domains (1) summary
      TIGR01700
      Location:44 → 297
      PNPH; purine nucleoside phosphorylase I, inosine and guanosine-specific

    2. NM_001380002.1 → NP_001368342.1  Purine nucleoside phosphorylase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PSA1
      Conserved Domains (1) summary
      TIGR01700
      Location:61 → 314
      PNPH; purine nucleoside phosphorylase I, inosine and guanosine-specific
    Nucleotide Protein
    Heading Accession and Version

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