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Bone morphogenetic protein 15 (BMP15) acts as a BMP and Wnt inhibitor during early embryogenesis. |
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These findings support the concept that an adequate amount of BMP15 secreted in the follicular fluid is critical for female fertility. |
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BMP15 variants do not play a significant role in human dizygotic twinning. |
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We analyzed two polymorphisms (-9C>G and IVS1+905A>G) within the BMP15 gene in women from Spain with polycystic ovary syndrome (PCOS). BMP15 gene does not seem to be associated with PCOS. |
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Findings indicate the role of BMP-15 in vivo in promoting follicle growth and preventing follicle maturation, resulting in an early decline in the ovarian reserve of transgenic mice. |
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characterization of the post-translational modification of recombinant BMP-15 mature protein (P16 and P17); findings are the first knowledge of the structure of rhBMP-15 mature protein toward understanding the molecular basis of BMP-15 function |
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phosphorylation state of rhBMP-15 and rhGDF-9 is a determinant of their agonistic and antagonistic activities |
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8. |
Observational study of gene-disease association. (HuGE Navigator) |
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9. |
a BMP15 alteration,as a possible cause of ovarian failure, previously described as a mutation, is instead a polymorphism |
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10. |
Mutational screening of the bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) genes in a population with premature ovarian failure (POF) identified no new mutations. |
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11. |
Hypergonadotropic ovarian failure is associated with an inherited mutation of human bone morphogenetic protein-15 gene. |
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12. |
comparison of the molecular characteristics of BMP-15 of polyovulatory mice with that of monoovulatory humans |
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13. |
interaction with growth and differentiation factor-9 and implication in aberrant ovarian phenotype |
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14. |
Data show that bone morphogenetic protein-15 activates the Smad pathway in granulosa cell models. |
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15. |
BMP-15 and GDF-9 have roles in fertility; critical sequences are determined by mutagenesis |
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16. |
Missense mutations in the BMP15 gene are associated with ovarian failure |
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17. |
although mutations in BMP15 and GDF9 are not a major cause of ovarian insufficiency, they may be involved in premature ovarian failure |