Official Symbol

MKRN3provided by HGNC

Official Full Name

makorin ring finger protein 3provided by HGNC

Primary Source

HGNC:7114

See related

Ensembl:ENSG00000179455; HPRD:04836; MIM:603856

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

D15S9; RNF63; ZFP127; ZNF127; MGC88288; MKRN3

Summary

The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq]

(plus) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 15; Location: 15q11-q13See MKRN3 in MapViewer

Preferred Names

makorin ring finger protein 3

Names

makorin ring finger protein 3

zinc finger protein 127

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

1. NG_012875.1 RefSeqGene

   Range

   5000..7713

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   GenBank FASTA Sequence Viewer (Graphics)

mRNA and Protein(s)

1. NM_005664.3 → NP_005655.1  makorin ring finger protein 3

   Source sequence(s)

   AI939624,BC044639,DA495139

   Consensus CDS

   CCDS10013.1

   UniProtKB/Swiss-Prot

   Q13064

   Related Ensembl

   ENSP00000313881, ENST00000314520

   Conserved Domains (2) summary

   cd00162
   Location:311 – 365
   Blast Score: 95

   RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...

   cl11592
   Location:95 – 121
   Blast Score: 93

   zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000015.9

   Range

   23810453..23813166

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   GenBank FASTA Sequence Viewer (Graphics)

2. NT_026446.14 

   Range

   245600..248313

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000058.1

   Range

   1971196..1973909

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   GenBank FASTA Sequence Viewer (Graphics)

2. NW_925783.1 

   Range

   192157..194870

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000147.1

   Range

   1945950..1948663

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001838194.1 

   Range

   252981..255694

   Download

   GenBank FASTA Sequence Viewer (Graphics)