1: TCEA1 transcription elongation factor A (SII), 1 [ Homo sapiens ]

GeneID: 6917 updated 3-Dec-2009

[Top][Help]Summary

Official Symbol
TCEA1provided by HGNC
Official Full Name
transcription elongation factor A (SII), 1provided by HGNC
Primary Source
HGNC:11612
See related
Ensembl:ENSG00000187735; HPRD:03252; MIM:601425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SII; TCEA; TF2S; GTF2S; TFIIS; TCEA1

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 8; Location: 8q11.2See TCEA1 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. transcription factor IIF, hepatitis delta antigen, and stimulatory factor II control human RNA polymerase II (RNAP II) pausing and transcript cleavage
PubMed 2. TFIIS has a role in suppression of transient pausing, which is the most important contribution of TFIIS to elongation from a stall position
PubMed 3. Results provide a model of the RNA polymerase II-transcription elongation factor TFIIS complex from X-ray diffraction data to 3.8 A resolution.
PubMed 4. PLAG1 protein is overexpressed in epithelial, myoepithelial, and mesenchymal-like tumor cells in tumors with fusions to CHCHD7 and TCEA1.
PubMed 5. Data shpw that SII is a major component of chromatin transcription and strongly synergizes with p300 (histone acetylation) at a step subsequent to preinitiation complex formation.
Submit: New GeneRIF Correction

[Top][Help]HIV-1 protein interactions

Protein    Interaction
1. Tat TFIIS synergizes with HIV-1 Tat during transactivation of the HIV-1 LTR promoter PubMed
2. HIV-1 Tat directly interacts with SII (TFIIS) as demonstrated by Tat-affinity column purification PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  NP_006747.1   NP_004706.2   CTDP1      HPRD    PubMed
 
  NP_006747.1   NP_005504.1   GTF2E1      HPRD    PubMed
 
  NP_006747.1   NP_000928.1   POLR2A      HPRD    PubMed
 
  NP_006747.1   RNA polymerase II        HPRD    PubMed
 
  Transcription elongation factor A, 1   NP_065746.2   REXO1      HPRD    PubMed
Reconstituted Complex
  BioGRID:112779   BioGRID:107457   CDK7      BioGRID    PubMed
Reconstituted Complex
  BioGRID:112779   BioGRID:107458   CDK8      BioGRID    PubMed
Reconstituted Complex
  BioGRID:112779   BioGRID:114597   CTDP1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:112779   BioGRID:109214   GTF2B      BioGRID    PubMed
Reconstituted Complex
  BioGRID:112779   BioGRID:109215   GTF2E1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:112779   BioGRID:109217   GTF2F1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:112779   BioGRID:109218   GTF2F2      BioGRID    PubMed
Reconstituted Complex
  BioGRID:112779   BioGRID:109220   GTF2H1      BioGRID    PubMed
Co-crystal Structure; Reconstituted Complex
  BioGRID:112779   BioGRID:111426   POLR2A      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:112779   BioGRID:121526   REXO1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:112779   BioGRID:112771   TBP      BioGRID    PubMed

[Top][Help]General gene information

Markers

D8S2054(e-PCR)
Links: UniSTS:62475
RH66562(e-PCR)
Links: UniSTS:91733
D3S4495(e-PCR)
Links: UniSTS:474550

Related pseudogene(s)

4 foundReview record(s) in Gene

Homology

Homologs of the TCEA1 gene The TCEA1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, and N.crassa.

Pathways

KEGG pathway: Basal transcription factors
03022
Reactome Event:DNA Repair
REACT_216
Reactome Event:Gene Expression
REACT_71
Reactome Event:HIV Infection
REACT_6185
Reactome Event:Transcription
REACT_1788

[Top][Help]General protein information

Preferred Names
transcription elongation factor A 1
Names
transcription elongation factor A 1

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_006756.2 → NP_006747.1  transcription elongation factor A 1 isoform 1

    Source sequence(s)
    AU280634,BM477937,BX538034,M81601,X62585
    Consensus CDS
    CCDS47858.1
    UniProtKB/Swiss-Prot
    P23193
    Related Ensembl
    ENSP00000382541, ENST00000399633
    Conserved Domains (4) summary
    cd00183
    Location:2 – 78
    Blast Score: 198
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    TIGR01385
    Location:4 – 301
    Blast Score: 830
    TFSII; transcription elongation factor S-II
    cl02609
    Location:261 – 299
    Blast Score: 191
    TFIIS_C; Transcription factor S-II (TFIIS)
    cl02637
    Location:136 – 250
    Blast Score: 388
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

  2. NM_201437.1 → NP_958845.1  transcription elongation factor A 1 isoform 2

    Source sequence(s)
    AU125645,AU280634,BX538034,M81601,X57198,X62585
    Consensus CDS
    CCDS47857.1
    UniProtKB/Swiss-Prot
    P23193
    Related Ensembl
    ENSP00000395483, ENST00000396401
    Conserved Domains (4) summary
    cd00183
    Location:2 – 57
    Blast Score: 110
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    TIGR01385
    Location:4 – 280
    Blast Score: 723
    TFSII; transcription elongation factor S-II
    cl02609
    Location:240 – 278
    Blast Score: 187
    TFIIS_C; Transcription factor S-II (TFIIS)
    cl02637
    Location:115 – 229
    Blast Score: 387
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000008.10

    Range
    54879115..54935007, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_008183.19 

    Range
    6743516..6799408, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000046.1

    Range
    37250597..37253213
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_921651.1 

    Range
    37250597..37253213
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000140.1

    Range
    50347343..50402985, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001839132.1 

    Range
    6746111..6801753, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC100821.2  (81958..137850)   None
  genomic   CH471068.1   EAW86739.1
       EAW86740.1
       EAW86741.1
  mRNA   AK026617.1   None
  mRNA   AK094425.1   None
  mRNA   AK290454.1   BAF83143.1
  mRNA   AK297729.1   BAH12657.1
  mRNA   AK297957.1   BAH12696.1
  mRNA   AU125645.1   None
  mRNA   AU280634.1   None
  mRNA   BC072460.1   AAH72460.1
  mRNA   BM477937.1   None
  mRNA   BT019995.1   AAV38798.1
  mRNA   BX538034.1   None
  mRNA   CR542221.1   CAG47017.1
  mRNA   CR604302.1   None
  mRNA   M81601.1   AAA61138.1
  mRNA   X57198.1   CAA40484.1
  mRNA   X62585.1   CAA44470.1
Protein Accession   Links
P23193.2   GenPept   UniProtKB/Swiss-Prot:P23193

[Top][Help]Additional Links