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    Tmem214 transmembrane protein 214 [ Mus musculus (house mouse) ]

    Gene ID: 68796, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem214provided by MGI
    Official Full Name
    transmembrane protein 214provided by MGI
    Primary source
    MGI:MGI:1916046
    See related
    Ensembl:ENSMUSG00000038828 AllianceGenome:MGI:1916046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110039B18Rik; 4921530J21Rik
    Summary
    Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasmic microtubule and cytosol. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in axial skeleton; chondrocranium; otic capsule; and rib. Orthologous to human TMEM214 (transmembrane protein 214). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 69.9), testis adult (RPKM 47.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B1; 5 16.9 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31026923..31034813)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30869579..30877469)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene dihydropyrimidinase-like 5 Neighboring gene STARR-seq mESC enhancer starr_12761 Neighboring gene predicted gene, 46907 Neighboring gene microtubule-associated protein, RP/EB family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E10311 Neighboring gene STARR-seq mESC enhancer starr_12763 Neighboring gene nuclear encoded tRNA alanine 15 (anticodon AGC) Neighboring gene nuclear encoded tRNA tyrosine 9 (anticodon GTA) Neighboring gene predicted gene, 35795 Neighboring gene ATP/GTP binding protein-like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis. Mugabo Y, et al. J Biol Chem, 2018 May 4. PMID 29530978, Free PMC Article
    2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20254

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 214

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144525.4 → NP_653108.2  transmembrane protein 214

      See identical proteins and their annotated locations for NP_653108.2

      Status: VALIDATED

      Source sequence(s)
      AC109606, AK034883
      Consensus CDS
      CCDS19164.1
      UniProtKB/Swiss-Prot
      Q3TLH3, Q3UPX9, Q78HK3, Q8BM55, Q8R0D5, Q8R237, Q8VC05
      UniProtKB/TrEMBL
      D3Z6S1
      Related
      ENSMUSP00000144615.2, ENSMUST00000201203.4
      Conserved Domains (1) summary
      pfam10151
      Location:217 → 683
      DUF2359; uncharacterized conserved protein (DUF2359)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31026923..31034813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165466.1 → XP_036021359.1  transmembrane protein 214 isoform X1

      Related
      ENSMUST00000202008.2
      Conserved Domains (1) summary
      pfam10151
      Location:1 → 378
      TMEM214; C-terminal, caspase 4 activator
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BM55.1 GenPept UniProtKB/Swiss-Prot:Q8BM55

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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