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1. |
EMMPRIN expression in tongue squamous cell carcinoma is significantly higher than in non-cancerous epithelium; is significantly associated with tumor diameter and clinical stage but not with gender, age, tumor metastasis and pathological grade. |
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2. |
EMMPRIN was expressed at cell membrane throughout entire lesion in tongue SCC. EMMPRIN was highly expressed in tongue SCC, and could induce local production of MMP-1. EMMPRIN might play important role in tongue SCC progression/invasion. |
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3. |
EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction. |
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4. |
Upregulation of CD147 expression is associated with nasopharyngeal carcinoma. |
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5. |
CD147 homophilic interactions in vivo are mediated through other partners. CD147 is also a substrate of its primary cyclophilin enzyme ligand, cyclophilin A. |
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6. |
maintained expression and even up-regulation of some (PNPT1, PMPCB, HMMR/RHAMM, BSG and ERCC1) tumor associated antigens in CD40-activated leukemic cells. |
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7. |
There is a positive correlation between CD147, VEGF expression, & tumor progression features, reflecting CD147's multifunctional role in advanced RCC as a mediator of tumor invasion & angiogenesis via stimulating VEGF production. |
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8. |
HAb18G/CD147 is significantly expressed in various cancers |
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9. |
Pathologic findings demonstrated that the intensity of CD147 staining in cancerous tissues was associated significantly with histological types, distant metastasis, and Nevin stages of gallbladder carcinomas. |
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10. |
upregulation of CD147 in a von Hippel-Lindau tumour suppressor gene defective renal cell carcinoma cell line. |
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11. |
Results provide a mechanism of malignancy of cervical carcinoma, in that the augmentation of EMMPRIN expression by tumor-stromal cell interaction progresses tumor invasion along with the increase of MMP expression via an active site of EMMPRIN. |
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12. |
EMMPRIN is widely distributed in the tubular epithelial cells of the adult human kidney and may regulate MMP-2 activity via its secretion from proximal tubular epithelial cells. |
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13. |
HAb18G/CD147 may play an important role in the inhibitory regulation of autophagy |
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14. |
upregulation of CD147 in human umbilical vein endothelial cells may play an important role in angiogenesis. |
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15. |
Human articular chondrocytes show extensive expression of CD147 in normal and osteoarthritic cartilage. |
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16. |
Presence of a highly divergent haplotype clade and possible reasons for its maintenance, including frequency-dependent balancing selection. |
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17. |
Interactions among hyaluronan, CD44, and emmprin contribute to regulation of monocarboxylate transporter in the cell membrane of breast cancer cells. |
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18. |
CD147 may functionally mediate tumor cells invasion and neoplasm invasiveness in multidrug resistnt hepatocellular carcinoma. |
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19. |
CD147 interacts with MCT1 and 4 to promote tumor cell glycolysis, resulting in the progression of MM |
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20. |
Proteome analysis of multidrug resistance of oral squamous carcinoma cells using CD147 silencing is reported. |
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21. |
ubiquitination of P-glycoprotein and CD147 might be a novel method for tumor therapy |
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22. |
Tumor growth positively correlated and animal survival negatively correlated with increasing EMMPRIN expression. FaDu/E tumor growth was significantly larger at 4 weeks compared with FaDu tumors (P = .006). |
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23. |
Results suggest that HAb18G/CD147 enhances the invasion and metastatic potentials of human hepatoma cells via integrin alpha3beta1-mediated FAK-paxillin and FAKPI3K-Ca(2+) signal pathways. |
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24. |
Cardiac-restricted overexpression of EMMPRIN causes myocardial remodeling and dysfunction in aging mice. |
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25. |
We are characterizing the functional importance of EMMPRIN in bladder cancer in order to evaluate this protein as a new target molecule for therapy. |
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26. |
The findings point to a role of EMMPRIN for the progression of adenocarcinoma of the lung that is unrelated to its function as inducer of MMPs. |
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27. |
The overall EMMPRIN expression in the epithelial lining of the 3 different types of odontogenic cyst was significantly higher than in the dental follicles. |
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28. |
Significantly higher CD147 expression is associated with prostate cancer. |
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29. |
Downregulation of CD147 affects hepatocellular carcinoma cell structure and function. |
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30. |
EMMPRIN regulates migration, MMP production by mouth cancer SCC cells and deposition of the TN-C matrix. |
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31. |
Increased CD147 expression is associated with differentiated thyroid carcinoma. |
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32. |
soluble EMMPRIN probably triggers the promotion of cancer invasion in vivo |
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33. |
Investigations as to whether specific tumor-stromal cell interactions mediated by CD147 promote colon cancer growth by utilizing small interfering (si)RNAs directed against human CD147. |
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34. |
CD147 expression influences Abeta levels by an indirect mechanism involving MMPs that can degrade extracellular Abeta. |
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35. |
the crystal structure of HAb18G/CD147 provides a good structural explanation for the established multifunction of CD147 mediated by homo/hetero-oligomerizations |
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36. |
cell surface basigin functions as a membrane receptor for soluble basigin and this homophilic interaction is not dependent upon glycosylation of the basigin ligand |
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37. |
EMMPRIN may regulate MMPs and be involved in prostate cancer progression |
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38. |
triggering CD43 and the underlying signaling pathways enhance LFA-1 adhesiveness while CD43 also negatively regulates LFA-1 induction via other receptors by dynamic interaction with either LFA-1 or CD147. |
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39. |
Results indicate that CD147 is involved in T-lymphoma progression. |
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40. |
Data propose that the CD147-NOD2 interaction serves as a molecular guide to regulate NOD2 function at sites of pathogen invasion. |
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41. |
the effect of Extracellular matrix metalloproteinase inducer (EMMPRIN)on its expression in corneal and skin fibroblasts |
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42. |
CD147, via the selective inhibition of specific downstream elements of the Vav1/Rac1 route, contributes to the negative regulation of T-cell responses. |
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43. |
The expression of EMMPRIN confers resistance to radiotherapy. Therefore, EMMPRIN expression in cervical cancer may be regarded both as a prognostic factor and a therapeutic target. |
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44. |
Coincubation of platelets with monocytes induced EMMPRIN-mediated nuclear factor kappaB activation in monocytes with increased MMP-9, interleukin-6, and tumor necrosis factor-alpha secretion by monocytes |
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45. |
EMMPRIN was preferentially expressed in most NSCLCs. High levels of expression were associated with early T stage and well-differentiated adenocarcinoma |
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46. |
EMMPRIN and MMP-2 are the major determinants of malignancy in cancers. |
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47. |
Multidrug resistant breast cancer cells with p-glycoprotein substrates could affect outcome through modulating the production of MMP9. |
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48. |
Low EMPRINN expression was found more often in serous tumors than in other types of epithelial ovarian cancer. It was associated with a better prognosis. |
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49. |
CD147 may assume a dual role, since it had intrinsic stimulative effects on breast cabcer tumor invasion in vitro as well as increasing resistance to P-gp substrate drugs. |
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50. |
The colocalization of EMMPRIN, MT1-MMP and TIMP-2 in human cervical carcinomas seems to be involved in a specific distribution pattern of tumor cell bound MMP-2, which is related with local proteolytic activity. |
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51. |
ECM remodeling is under the control of induction and inhibition of matrix degrading protease and the novel MMP inducer, EMMPRIN may play a role in influx and differentiation of monocytes and destabilizing atheroma |
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52. |
expression of CD147 is upregulated during the differentiation of monocyte THP-1 cells to macrophage cells, and CD147 induces the secretion and activation of MMP-2 and MMP-9 and enhances the invasive ability of THP-1 cells |
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53. |
shrew-1 has a function in the regulation of cellular invasion, which may involve its interaction with CD147 |
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54. |
breast cancer cells expressed EMMPRIN isoforms differing in the presence or absence of Lewis X glycan structures |
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55. |
CD147 siRNA down-regulated the expression of vascular endothelial growth factor in malignant melanoma cells and reduced the migration of vascular endothelial cells. |
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56. |
Expression of EMMPRIN protein may be detected in hepatocellular carcinoma(HCC), but it may play little role in the invasion and metastasis of HCC. |
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57. |
Upregulated EMMPRIN contributes to growth and angiogenesis of gastric carcinoma |
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58. |
CD147 downregulation by RNAi technology decreases the invasive capability of prostate cancer cells. |
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59. |
Data demonstrated that there are two different forms of HAb18G/CD147 differing in degree and types of glycosylation. |
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60. |
Increased CD147 on monocytes/macrophages in rheumtaoid arthritis may cause elevated matrix metalloproteinase secretion, cell invasion & cyclophilin-A-mediated cell migration into the joints; this may lead to to cartilage & bone destruction. |
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61. |
findings show for the first time that EMMPRIN is overexpressed in malignant ovary tumors |
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62. |
results show that in both tumor and fibroblast cells EMMPRIN regulates VEGF production via the PI3K-Akt pathway but not via the MAPK, JUN, or p38 kinase pathways |
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63. |
degree of staining of CD147 was significantly higher in hepatocellular (HCC) tumor tissues than non-tumor tissues; expression was significantly elevated in HCC tissue specimens from patients with a low value of serum AST and gamma-GTP |
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64. |
Chlamydia pneumoniae infection implicated as an important etiologic factor of atherosclerosis was found to be associated with the induction of matrix metalloproteinases (MMPs), upregulated by EMMPRIN. |
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65. |
CD147 is a major carrier of beta1,6-branched polylactosamine sugars on tumor cells |
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66. |
Depletion of CD147 by RNA interference was found to increase the production of amyloid beta-peptides. |
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67. |
Increased expression of EMMPRIN in tumor cells is associated with poor prognosis of patients with papillary renal cell carcinoma |
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68. |
These data show that elevated cytokines may play a role in the establishment of ectopic endometrium in the peritoneal cavity without any change in EMMPRIN expression, in fact the inhibitory effect of TGF-beta1 involved a reduction in EMMPRIN mRNA levels. |
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69. |
Increased EMMPRIN levels in gingival crevicular fluid are associated with the enhanced severity of periodontal inflammation, indicating that it can participate in the regulation of disease progression. |
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70. |
role of EMMPRIN in tumor invasion, metastasis, and neoangiogenesis by stimulating extracellular matrix remodeling around tumor cell clusters, stroma, and blood vessels |
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71. |
expression of EMMPRIN is responsible for the increased activity of matrix metalloproteinases in MDR cell lines |
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72. |
study indicates the functional interaction between CD98 and CD147 in the regulation of cell fusion |
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73. |
expressed in Hodgkin's lymphoma and anaplastic large cell lymphoma |
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74. |
extracellular matrix degradation by fibroblasts is controlled through the microvesicular release of EMMPRIN from tumor cells |
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75. |
Up-regulation of EMMPRIN by epidermal growth factor and transforming growth factor-beta, demonstrate a role in wound healing. |
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76. |
These results suggest that EMMPRIN overexpression occurs at a very early stage of oral carcinogenesis and plays a contributing role in OSCC tumorigenesis. |
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77. |
Expressed in human endometrium during menstrual cycle. Expression and glycosylation augmented by progesterone. May be involved in extracellular matrix(ECM) breakdown at interface between endometrial cells and ECM by using EMMPRIN-bound MMP-1. |
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78. |
EMMPRIN may be an important regulatory factor involved in the biological behaviors of giant cell tumor |
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79. |
Our results suggest an importance of the direct cell-cell interaction involving EMMPRIN rather than humoral factors such as cytokines for pro-MMP-2 production and activation followed by tumor progression, invasion, and metastasis in laryngeal cancer |
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80. |
Results suggest a novel tumor angiogenesis mechanism in which tumor-associated EMMPRIN functionally mediates tumor-stroma interactions and directly contributes to tumor angiogenesis and growth by stimulating VEGF and MMP expression. |
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81. |
Active site residues of cyclophilin A are crucial for its signaling activity via CD147 |
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82. |
review of role of emmprin as a major mediator of malignant cell behavior |
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83. |
fibroblast-derived MMPs but not those from tumor cells are important for in vitro collagenolysis and that this process is promoted by tumor cell-expressed EMMPRIN |
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84. |
EMMPRIN and MT1-MMP are upregulated on monocytes in acute MI. During cellular interactions, EMMPRIN stimulates MMP-9 in monocytes and MMP-2 in smooth muscle cells. |
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85. |
We propose that TM3 of MCT1 lies alongside the TM of basigin with Arg86 adjacent to Glu218 of basigin. |
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86. |
Vesicles shed by ovarian cancer cells may induce proangiogenic activities of human umbilical vein endothelial cells (HUVECs) by a CD147-mediated mechanism. |
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87. |
BSG residues (22)AAGTVFTTVEDLGSKILLTCSLNDSATEV(50) may play a critical role in the inhibitory functions of monoclonal antibody HAb18G/CD147 on matrix metalloproteinase secretion and tumor invasion. |
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88. |
HAb18G/CD147 plays an important role in HCC invasion and metastasis mainly via modulating fibroblasts |
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89. |
showed highly specific association with caveolin-1 on the surface of multiple cell types |
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90. |
placenta and fetal membranes express EMMPRIN, with the potential to stimulate MMP production, facilitating fetal membrane rupture and detachment of the placenta and fetal membranes from the maternal uterus at the time of parturition. |
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91. |
Antibody targeting of T cell activation-associated antigen CD147 prevents T cell receptor (TCR) stimulation-dependent reorganization and clustering of membrane microdomains and suggests a general mechanism for inhibition of receptor signaling. |
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92. |
variations in EMMPRIN glycosylation forms are associated with either MMP-2 or MMP-9 activity |
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93. |
a cyclophilin-related protein is involved in CD147 cell surface expression |
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94. |
model in which tumor cell-associated EMMPRIN stimulates MMPs, as well as EMMPRIN expression in tumor stroma |
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95. |
EMMPRIN has a role in progression of human breast cancer |
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96. |
cyclophilin B receptor; mediates calcium signaling and neutrophil chemotaxis induced by cyclophilin B |
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97. |
Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts |
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98. |
cyclophilin 60 regulates cell surface expression of CD147/EMMPRIN |
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99. |
Extracellular matrix metalloproteinase inducer is induced upon monocyte differentiation and is expressed in human atheroma as well as in GM-CSF-differentiated peripheral blood monocytes and macrophage foam cells. |
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100. |
CD147 is a transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion [review] |
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101. |
EMMPRIN stimulates fibroblast MMP2 release. |
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102. |
results indicated that expression of EMMPRIN protects cancer cells from anoikis and that this effect is mediated at least in part by a MAP kinase-dependent reduction of Bim |
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103. |
CD147 may be important factor in progressive joint destruction of rheumatoid arthritis(RA) and may be potential therapeutic target in RA treatment. |
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104. |
MT1-MMP-dependent cleavage eliminates the functional N-terminal domain of EMMPRIN from the cell surface, which is expected to down-regulate its function. |