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    Rnmt RNA (guanine-7-) methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 67897, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rnmtprovided by MGI
    Official Full Name
    RNA (guanine-7-) methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1915147
    See related
    Ensembl:ENSMUSG00000009535 AllianceGenome:MGI:1915147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rg7mt1; mKIAA0398; 2610002P10Rik
    Summary
    Predicted to enable RNA binding activity and mRNA (guanine-N7-)-methyltransferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of mRNA cap binding activity complex; mRNA cap methyltransferase complex; and receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and skin. Orthologous to human RNMT (RNA guanine-7 methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 9.2), CNS E14 (RPKM 8.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnmt in Genome Data Viewer
    Location:
    18 E2; 18 41.22 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (68433406..68457923)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (68300233..68324852)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9174 Neighboring gene STARR-seq mESC enhancer starr_44926 Neighboring gene family with sequence similarity 210, member A Neighboring gene microRNA 7219 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:68459940-68460049 Neighboring gene STARR-seq mESC enhancer starr_44927 Neighboring gene predicted gene, 54023 Neighboring gene melanocortin 5 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation. Galloway A, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34125914, Free PMC Article
    2. 5,10-Methylenetetrahydrofolate reductase becomes phosphorylated during meiotic maturation in mouse oocytes. Young K, et al. Zygote, 2022 Oct. PMID 35652653
    3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    4. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. Zhou X, et al. J Cell Biol, 2015 Sep 14. PMID 26370502, Free PMC Article
    5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation.
      Title: Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 7-methylguanosine mRNA capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 7-methylguanosine mRNA capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA capping enzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mRNA cap guanine-N7 methyltransferase
    Names
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase
    NP_001164424.1
    NP_001347931.1
    NP_001347932.1
    NP_080716.1
    XP_006526256.1
    XP_006526260.1
    XP_011245293.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170953.1 → NP_001164424.1  mRNA cap guanine-N7 methyltransferase isoform 2

      See identical proteins and their annotated locations for NP_001164424.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the 3' coding region, compared to variant 3. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC111069, AK129130, CO039099
      Consensus CDS
      CCDS50314.1
      UniProtKB/Swiss-Prot
      Q9D0L8
      Related
      ENSMUSP00000025427.8, ENSMUST00000025427.14
      Conserved Domains (2) summary
      COG0500
      Location:160 → 335
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl17173
      Location:125 → 409
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001361002.1 → NP_001347931.1  mRNA cap guanine-N7 methyltransferase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      AC111069
      Consensus CDS
      CCDS37852.1
      UniProtKB/Swiss-Prot
      Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
      Conserved Domains (1) summary
      pfam03291
      Location:125 → 464
      Pox_MCEL; mRNA capping enzyme

    3. NM_001361003.1 → NP_001347932.1  mRNA cap guanine-N7 methyltransferase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      AC111069
      Consensus CDS
      CCDS37852.1
      UniProtKB/Swiss-Prot
      Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
      Conserved Domains (1) summary
      pfam03291
      Location:125 → 464
      Pox_MCEL; mRNA capping enzyme

    4. NM_026440.4 → NP_080716.1  mRNA cap guanine-N7 methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_080716.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      AC111069, AK129130, CO039099
      Consensus CDS
      CCDS37852.1
      UniProtKB/Swiss-Prot
      Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
      Related
      ENSMUSP00000009679.5, ENSMUST00000009679.11
      Conserved Domains (1) summary
      pfam03291
      Location:125 → 464
      Pox_MCEL; mRNA capping enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      68433406..68457923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246991.4 → XP_011245293.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011245293.1

      UniProtKB/Swiss-Prot
      Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
      Conserved Domains (1) summary
      pfam03291
      Location:125 → 464
      Pox_MCEL; mRNA capping enzyme

    2. XM_006526193.5 → XP_006526256.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006526256.1

      UniProtKB/Swiss-Prot
      Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
      Conserved Domains (1) summary
      pfam03291
      Location:125 → 464
      Pox_MCEL; mRNA capping enzyme

    3. XM_006526197.5 → XP_006526260.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006526260.1

      UniProtKB/Swiss-Prot
      Q3V3U9, Q6ZQC6, Q9D0L8, Q9D5F1
      Conserved Domains (1) summary
      pfam03291
      Location:125 → 464
      Pox_MCEL; mRNA capping enzyme

    RNA

    1. XR_004939884.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0L8.1 GenPept UniProtKB/Swiss-Prot:Q9D0L8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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