Entrez Gene Home

Recent activity

1: SOX17 SRY (sex determining region Y)-box 17 [ Homo sapiens ]

GeneID: 64321 updated 4-Dec-2009

[Top][Help]Summary

Official Symbol
SOX17provided by HGNC
Official Full Name
SRY (sex determining region Y)-box 17provided by HGNC
Primary Source
HGNC:18122
See related
Ensembl:ENSG00000164736; HPRD:18085; MIM:610928
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLJ22252; SOX17
Summary
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 8; Location: 8q11.23See SOX17 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. Sox17 protects benign tumors from malignant progression at an early stage of tumorigenesis, and down-regulation of Sox17 contributes to malignant progression through promotion of Wnt activity.
PubMed 2. stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX17 producing definitive endoderm progenitors
PubMed 3. SOX2 and SOX17 expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful.
PubMed 4. stable expression induces a stable expandable definitive endoderm phenotype in hESCs
PubMed 5. SOX17-Chromatin immunoprecipitation identified zinc finger protein 202 (Zfp202) as a direct target of SOX17 during endoderm differentiation of F9 embryonal carcinoma cells.
PubMed 6. Observational study of gene-disease association. (HuGE Navigator)
PubMed 7. SOX17 silencing due to promoter hypermethylation is an early event during tumorigenesis and may contribute to aberrant activation of Wnt signaling in colorectal cancer.
Submit: New GeneRIF Correction

[Top][Help]General gene information

Markers

RH93135(e-PCR)
Links: UniSTS:85070

Homology

Homologs of the SOX17 gene The SOX17 gene is conserved in chimpanzee, dog, cow, mouse, rat, and chicken.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Wnt signaling pathway
04310

[Top][Help]General protein information

Preferred Names
SRY-box 17
Names
SRY-box 17
SRY-related HMG-box transcription factor SOX17

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_022454.3 → NP_071899.1  SRY-box 17

    Source sequence(s)
    AC091076,AK025905,DA874945
    Consensus CDS
    CCDS6159.1
    UniProtKB/Swiss-Prot
    Q9H6I2
    Related Ensembl
    ENSP00000297316, ENST00000297316
    Conserved Domains (1) summary
    cd01388
    Location:67 – 135
    Blast Score: 265
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000008.10

    Range
    55370494..55373455
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_008183.19 

    Range
    7234895..7237856
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000051.1

    Range
    51361038..51363999
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_923929.1 

    Range
    8494103..8497064
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000140.1

    Range
    50838616..50841577
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001839132.1 

    Range
    7237384..7240345
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC091076.7  (131696..134132)   None
  genomic   CH471068.1   EAW86748.1
  mRNA   AB073988.1   BAB83867.1
  mRNA   AK025905.1   BAB15277.1
  mRNA   BC030209.1   AAH30209.1
  mRNA   BC111365.1   AAI11366.1
  mRNA   BC111770.1   AAI11771.1
  mRNA   DA874945.1   None
  other-genetic   BC140307.1   AAI40308.1
Protein Accession   Links
Q2NKK5   GenPept   UniProtKB/TrEMBL:Q2NKK5
Q2T9L5   GenPept   UniProtKB/TrEMBL:Q2T9L5
Q9H6I2.1   GenPept   UniProtKB/Swiss-Prot:Q9H6I2

[Top][Help]Additional Links

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.