Official Symbol

SDHAprovided by HGNC

Official Full Name

succinate dehydrogenase complex, subunit A, flavoprotein (Fp)provided by HGNC

Primary Source

HGNC:10680

See related

Ensembl:ENSG00000073578; HPRD:02914; MIM:600857

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

FP; SDH1; SDH2; SDHF; SDHA

Summary

This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. [provided by RefSeq]

(plus) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 5; Location: 5p15See SDHA in MapViewer

Preferred Names

succinate dehydrogenase complex, subunit A, flavoprotein

Names

succinate dehydrogenase complex, subunit A, flavoprotein

succinate dehydrogenase complex flavoprotein subunit

NP_004159.2

EC 1.3.5.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

1. NG_012339.1 RefSeqGene

   Range

   5000..43459

   Download

   GenBank FASTA Sequence Viewer (Graphics)

mRNA and Protein(s)

1. NM_004168.2 → NP_004159.2  succinate dehydrogenase complex, subunit A, flavoprotein precursor

   Source sequence(s)

   BC001380,CA427314,D30648,DA160919

   Consensus CDS

   CCDS3853.1

   UniProtKB/Swiss-Prot

   P31040

   Related Ensembl

   ENSP00000264932, ENST00000264932

   Conserved Domains (3) summary

   pfam02910
   Location:512 – 664
   Blast Score: 523

   Succ_DH_flav_C; Fumarate reductase/succinate dehydrogenase flavoprotein C-terminal domain

   PTZ00139
   Location:53 – 664
   Blast Score: 2780

   PTZ00139; succinate dehydrogenase (flavoprotein) subunit; Provisional

   cl11411
   Location:85 – 471
   Blast Score: 591

   Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000005.9

   Range

   218355..256814

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_006576.16 

   Range

   208355..246814

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000048.1

   Range

   317917..356376

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_922496.1 

   Range

   205845..244304

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000137.1

   Range

   208246..246713, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001838923.2 

   Range

   1876257..1914724, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)