Cd200r1 CD200 receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd200r1provided by MGI
Official Full Name: CD200 receptor 1provided by MGI
Primary source: MGI:MGI:1889024
See related: Ensembl:ENSMUSG00000022667 AllianceGenome:MGI:1889024
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OX2R; Mox2r; CD200R
Summary: Enables signaling receptor activity. Predicted to be involved in several processes, including negative regulation of interleukin-6 production; negative regulation of leukocyte migration; and negative regulation of neuroinflammatory response. Located in external side of plasma membrane. Is expressed in central nervous system; liver lobe; retina; and thymus primordium. Orthologous to several human genes including CD200R1 (CD200 receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E18 (RPKM 1.8), liver E14 (RPKM 1.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B4; 16 29.08 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (44586141..44615341)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (44765736..44794977)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-kappaB signaling pathway in aged mice.
Title: Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice.
Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
Title: Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation.
Title: CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation.
CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury.
Title: CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury.
MicroRNA-129-5p-regulated microglial expression of the surface receptor CD200R1 controls neuroinflammation.
Title: MicroRNA-129-5p-regulated microglial expression of the surface receptor CD200R1 controls neuroinflammation.
CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway.
Title: CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway.
The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease.
Title: The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease.
CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
Title: CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma.
Title: CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma.
Agonists of CD200R1 may be beneficial for eosinophilic pathologies.
Title: CD200R1 regulates eosinophilia during pulmonary fungal infection in mice.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding involved in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: cell surface glycoprotein CD200 receptor 1

Names: CD200 cell surface glycoprotein receptor; Orexin receptor 2; antigen identified by monoclonal antibody MRC OX-2 receptor; cell surface glycoprotein OX2 receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021325.4 → NP_067300.1 cell surface glycoprotein CD200 receptor 1 precursor

See identical proteins and their annotated locations for NP_067300.1

Status: VALIDATED

Source sequence(s)

AC122217

Consensus CDS

CCDS28189.1

UniProtKB/Swiss-Prot

Q9ES57

Related

ENSMUSP00000053822.9, ENSMUST00000057488.15

Conserved Domains (3) summary

smart00410
Location:106 → 146

IG_like; Immunoglobulin like

pfam07686
Location:42 → 147

V-set; Immunoglobulin V-set domain

cl11960
Location:162 → 222

Ig; Immunoglobulin domain