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1. |
Endoplasmic reticulum stress may underlie the local downregulation of resistin mRNA and protein in fat in murine obesity. |
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2. |
TWEAK has a role in increases in endothelial cell migration and proliferation due to resistin during angiogenesis |
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3. |
Resistin impairs insulin-stimulated glucose uptake by mechanisms involving reduced plasma membrane GLUT4 translocation. |
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4. |
a composite enhancer binding both PPARgamma and C/EBPa,b factors confers adipocyte-specific expression to Retn in mouse, and its absence from the human gene may explain the lack of adipocyte expression in humans. |
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5. |
Murine resistin induces endothelial cell migration and sprouting of cellular networks via a mechanism which appears dependent upon PI3K and NF-kappaB activity, but independent of altered NO production. |
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6. |
Resistin has a role in promoting hepatic steatosis and hyperlipidemia inobese mice. |
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7. |
TNF-alpha suppresses resistin expression by inducing iNOS expression, thus causing overproduction of NO, which downregulates resistin gene expression. |
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8. |
Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor-alpha and extracellular signal-regulated kinase pathways. |
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9. |
Fat tissue mass affects insulin sensitivity by altering the expression and secretion of resistin |
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10. |
Hyperhomocysteinemia may promote insulin resistance through the induction of resistin expression and secretion from adipocytes. |
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11. |
Administration of resistin to adipocytes mimicked the effects of GIP on the PKB/LKB1/AMPK/LPL pathway: increasing phosphorylation of PKB, reducing levels of phosphorylated LKB1 and AMPK, and increasing LPL activity. |
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12. |
resistin is a factor that may regulate beta-cell function/viability, potential mechanism by which increased adiposity causes beta-cell dysfunction. |
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13. |
Resistin exerts a novel autocrine/paracrine control over fiaf and socs-3 expression in both 3T3-L1 adipocytes and N-1 neurons. |
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14. |
Inhibits insulin-stimulaed glucose uptake into skeletal muscle cells without affecting insulin signaling pathways. Review. |
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15. |
PPARgamma activation represses the expression of the resistin gene by modulating Sp1 activity |
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16. |
Results indicate that resistin may play a role in bone remodeling. |
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17. |
activation of Oct-2 is a part of lipopolysaccharide signalling pathways in macrophages |
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18. |
reductions in resistin mRNA levels involve a destabilization of the resistin mRNA molecule |
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19. |
during in vivo bone formation and remodeling, probably acting as a co-factor or accessory protein that modulates the effects of primary signaling molecules |
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20. |
Decreases in Rstn production and secretion induced by IGF-I may be related to the mechanism by which IGF-I modulates body weight and diabetes in animals. |
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21. |
mice lacking resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production; data support a physiological function for resistin in the maintenance of blood glucose during fasting |
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22. |
These results provide strong support for a physiological role of resistin in the development of hepatic insulin resistance. |
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23. |
results indicate that chronic "hyper-resistinemia" leads to whole-body insulin resistance involving impaired insulin signaling in skeletal muscle, liver, and adipose tissue, resulting in glucose intolerance, hyperinsulinemia, and hypertriglyceridemia |
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24. |
expression and regulation in mouse pituitary; data suggest that local resistin expression could have functional implications during prepubertal maturation of the hypothalamic-pituitary system |
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25. |
These data suggest that EGCG downregulates Rstn expression via a pathway that is dependent on the ERK pathway. |
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26. |
Mechanisms regulating adipocyte expression of resistin |
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27. |
Data show that neuropeptie Y significantly increased resistin mRNA expression in white adipose tissue compared with artificial cerebrospinal fluid treated controls. |
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28. |
Plasma resistin of leptin-treated mice was barely decreased. |
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29. |
resistin does not alter insulin receptor signaling but does affect insulin-stimulated glucose uptake, presumably by decreasing the intrinsic activity of cell surface glucose transporters |
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30. |
Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes |
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31. |
the expression of resistin and RELMalpha are similarly regulated in adipose tissue despite the fact that RELMalpha is exclusively expressed in the stromal vascular fraction of adipose tissue and not in adipocytes |
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32. |
Resistin is regulated and expressed in mouse brown adipocytes |
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33. |
Despite severe weight loss and significant falls in leptin expression and insulin concentration, resistin gene expression appears unchanged in white adipose tissue of mice with MAC16 tumour. |
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34. |
ADSF/resistin secretion controls fat cell differentiation and adipose tissue development. |
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35. |
Resistin ) mRNA was increased in the cortex only at 21 days after hypoxia/ischaemia |
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36. |
crystal structure reveals hexameric assemblies consisting of trimers linked to form hexamers through highly exposed disulfide bonds; structure suggests possible regulation through disulfide cleavage or by regulation during assembly |
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37. |
Nutritional regulation of resistin and changes in resistin gene expression and circulating levels in obesity are mediated, at least in part, through insulin and glucose. |
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38. |
gender differences in resistin, adiponectin and leptin mRNA expression and plasma levels were not ablated by castration and seem to be dependent on other factors in addition to gonadal steroids |
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39. |
Chronic hyperresistinemia impairs normal glucose metabolism. |
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40. |
possible role of resistin in cardiovascular disease |
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41. |
Directly impairs glucose transport; and in contrast to effects on the liver, these actions of resistin require oligomerization. |
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42. |
Resistin overexpression induces dyslipidemia in mice, which is commonly seen in the insulin-resistant state, partially through enhanced secretion of lipoproteins. |
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43. |
In C57BL/6J mice with diet-induced obesity but wild-type leptin alleles, resistin deficiency reduced hepatic glucose production and increased peripheral glucose. |
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44. |
Pituitary resistin expression is age- and gender-dependent. In ob/ob and fasted mice, resistin is regulated in a tissue-specific manner. Visceral fat obesity increases but starvation decreases resistin mRNA. |
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45. |
resistin is a novel secreted factor first identified as a TZD-suppressible gene |
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46. |
Mice implanted with 3T3-L1 cells overexpressing resistin showed significantly increased plasma resistin levels and decreased insulin sensitivity. |
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47. |
Resistin expression is regulated by C-EBP Proteins, peroxisome proliferator-activated receptor, and signal-transducing molecules. |
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48. |
Article reviews recent studies of Resistin/ADSF/FIZZ3 in transgenic and knockout mice. |
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49. |
examined the effect on resistin expression of various hormones and cytokines known to affect insulin sensitivity. |
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50. |
demonstrates in vivo the inhibitory role of ADSF in adipogenesis |
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51. |
results indicate that the substantial reduction of adiposity in lactation does not lead to any changes in resistin gene expression in white adipose tissue |
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52. |
Data demonstrate that basal and hormonal stimulation of resistin secretion by insulin is inhibited by ET-1. |
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53. |
results demonstrate that leptin decreases resistin expression and suggest that resistin may influence glucose homeostasis |