Official Symbol

EIF4ENIF1provided by HGNC

Official Full Name

eukaryotic translation initiation factor 4E nuclear import factor 1provided by HGNC

Primary Source

HGNC:16687

See related

Ensembl:ENSG00000184708; HPRD:10456; MIM:607445

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

4E-T; Clast4; FLJ21601; FLJ26551; EIF4ENIF1

Summary

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 22; Location: 22q11.2See EIF4ENIF1 in MapViewer

Preferred Names

eukaryotic translation initiation factor 4E nuclear import factor 1

Names

eukaryotic translation initiation factor 4E nuclear import factor 1

2610509L04Rik

eIF4E-transporter

OTTHUMP00000063276

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001164501.1 → NP_001157973.1  eukaryotic translation initiation factor 4E nuclear import factor 1 isoform a

   Description

   Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.

   Source sequence(s)

   AA609351,AK314636,BC032941,BC033028,DA336484

   UniProtKB/Swiss-Prot

   Q9NRA8

   Conserved Domains (1) summary

   pfam10477
   Location:30 – 706
   Blast Score: 901

   EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

2. NM_001164502.1 → NP_001157974.1  eukaryotic translation initiation factor 4E nuclear import factor 1 isoform b

   Description

   Transcript Variant: This variant (3) lacks an alternate in-frame segment in the coding region compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

   Source sequence(s)

   AA609351,AK314636,BC032941

   UniProtKB/TrEMBL

   B1AKL3

   UniProtKB/Swiss-Prot

   Q9NRA8

   Conserved Domains (1) summary

   pfam10477
   Location:100 – 532
   Blast Score: 323

   EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

3. NM_019843.3 → NP_062817.2  eukaryotic translation initiation factor 4E nuclear import factor 1 isoform a

   Description

   Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.

   Source sequence(s)

   AA609351,AK314636,BC032941

   Consensus CDS

   CCDS13898.1

   UniProtKB/Swiss-Prot

   Q9NRA8

   Related Ensembl

   ENSP00000328103, ENSP00000380659, ENSP00000409372, ENST00000330125, ENST00000397525, ENST00000420671

   Conserved Domains (1) summary

   pfam10477
   Location:30 – 706
   Blast Score: 901

   EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000022.10

   Range

   31835354..31885703, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_011520.12 

   Range

   11225923..11276272, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000065.1

   Range

   15635842..15686211, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_927628.1 

   Range

   9902036..9952405, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000154.1

   Range

   14796270..14846514, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001838745.1 

   Range

   9923403..9973647, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)