Prickle3 prickle planar cell polarity protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prickle3provided by MGI
Official Full Name: prickle planar cell polarity protein 3provided by MGI
Primary source: MGI:MGI:1859635
See related: Ensembl:ENSMUSG00000031145 AllianceGenome:MGI:1859635
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pk3; Lmo6; Sfc16
Summary: Predicted to enable zinc ion binding activity. Predicted to act upstream of or within cell projection organization. Located in mitochondrion. Is expressed in several structures, including ear; early conceptus; female reproductive system; lower urinary tract; and nervous system. Used to study Leber plus disease. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy. Orthologous to human PRICKLE3 (prickle planar cell polarity protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in mammary gland adult (RPKM 15.2), stomach adult (RPKM 14.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.45 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (7523616..7535086)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (7657379..7668197)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.
Title: PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

DXImx29 (e-PCR), detects polymorphism
- UniSTS:186213

NoName (e-PCR)
- UniSTS:234433

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prickle planar cell polarity protein 3

Names: LIM domain only protein 6; prickle homolog 3; prickle-like protein 3; triple LIM domain protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290624.2 → NP_001277553.1 prickle planar cell polarity protein 3

See identical proteins and their annotated locations for NP_001277553.1

Status: VALIDATED

Source sequence(s)

AL672231

Consensus CDS

CCDS72329.1

UniProtKB/Swiss-Prot

B1AVA9, Q80VL3, Q8CAY9

UniProtKB/TrEMBL

Q8CIL5

Related

ENSMUSP00000033485.8, ENSMUST00000033485.14

Conserved Domains (4) summary

cd09415
Location:186 → 244

LIM1_Prickle; The first LIM domain of Prickle

cd09418
Location:249 → 304

LIM2_Prickle; The second LIM domain of Prickle

cd09420
Location:309 → 367

LIM3_Prickle; The third LIM domain of Prickle

cd09827
Location:82 → 178

PET_Prickle; The PET domain of Prickle

RNA

NR_189670.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL672231

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

7523616..7535086

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_175097.3: Suppressed sequence

Description

NM_175097.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.