Official Symbol

Mefvprovided by MGI

Official Full Name

Mediterranean feverprovided by MGI

Primary Source

MGI:1859396

See related

Ensembl:ENSMUSG00000022534

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Mus musculus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus

Also known as

FMF; pyrin; TRIM20; MGC124344; MGC124345; Mefv

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 16; Location: 16 A1; 16 1.1 cMSee Mefv in MapViewer

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

• Targeted (Reporter) (1)  1 citation

Preferred Names

Mediterranean fever

Names

Mediterranean fever

marenostrin

familial mediterranean fever

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001161790.1 → NP_001155262.1  Mediterranean fever isoform 1

   Description

   Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

   Source sequence(s)

   AC139347,AV372338,BB624975,BC108994,CJ272618

   UniProtKB/TrEMBL

   Q32MT0

   Conserved Domains (2) summary

   cd00021
   Location:472 – 511
   Blast Score: 129

   BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

   pfam02758
   Location:7 – 88
   Blast Score: 272

   PAAD_DAPIN; PAAD/DAPIN/Pyrin domain

2. NM_001161791.1 → NP_001155263.1  Mediterranean fever isoform 2

   Description

   Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences compared to variant 1, one of which results in a frameshift. This results in a shorter isoform (2) with a distinct C-terminus, compared to isoform 1.

   Source sequence(s)

   AC139347,AV372338,BB624975,BC108993,CJ272618

   UniProtKB/TrEMBL

   Q32MT1

   Conserved Domains (2) summary

   cd00021
   Location:442 – 481
   Blast Score: 130

   BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

   pfam02758
   Location:7 – 88
   Blast Score: 269

   PAAD_DAPIN; PAAD/DAPIN/Pyrin domain

3. NM_019453.2 → NP_062326.2  Mediterranean fever isoform 3

   Description

   Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.

   Source sequence(s)

   AC139347

   Consensus CDS

   CCDS27907.1

   Related Ensembl

   ENSMUSP00000023180, ENSMUST00000023180

   Conserved Domains (2) summary

   cd00021
   Location:442 – 481
   Blast Score: 129

   BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

   pfam02758
   Location:7 – 88
   Blast Score: 270

   PAAD_DAPIN; PAAD/DAPIN/Pyrin domain

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference assembly (C57BL/6J)

Genomic

1. NC_000082.5

   Range

   3707214..3718096, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_039624.7 

   Range

   707214..718096, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (based on Celera)

Genomic

1. AC_000038.1

   Range

   4345681..4356358, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001030584.1 

   Range

   224292..234969, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)