B3galt4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: B3galt4provided by MGI
Official Full Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4provided by MGI
Primary source: MGI:MGI:1859517
See related: Ensembl:ENSMUSG00000067370 AllianceGenome:MGI:1859517
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Galt2; Gal-T2
Summary: Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Predicted to be involved in ganglioside biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human B3GALT4 (beta-1,3-galactosyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34168886..34170462, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (33949912..33951488, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma.
Title: B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma.
activation of a fragment of 211 bp around the transcription initiation site of the mouse Gal-T2 promoter.
Title: ETS-1 transcription factor activates the expression of mouse UDP-Gal:GA2/GM2/GD2/GT2 galactosyltransferase gene.

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General gene information

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Markers

AF082504 (e-PCR)
- UniSTS:163585

B3galt4 (e-PCR), detects polymorphism
- UniSTS:463401

B3galt4 (e-PCR), detects polymorphism
- UniSTS:507997

NoName (e-PCR)
- UniSTS:488694

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables ganglioside galactosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ganglioside biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-1,3-galactosyltransferase 4

Names: UDP-Gal:betaGlcNAc beta 13-galactosyltransferase polypeptide 4; UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase; b3Gal-T4; beta-1,3-GalTase 4; beta3Gal-T4; beta3GalT4; ganglioside galactosyltransferase

NP_062293.1

EC 2.4.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.