Rcan2 regulator of calcineurin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rcan2provided by MGI
Official Full Name: regulator of calcineurin 2provided by MGI
Primary source: MGI:MGI:1858219
See related: Ensembl:ENSMUSG00000039601 AllianceGenome:MGI:1858219
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Csp2; MCIP2; ZAKI-4; Dscr1l1
Summary: Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; locomotion involved in locomotory behavior; and short-term memory. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; heart; and retina. Orthologous to human RCAN2 (regulator of calcineurin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 48.9), cerebellum adult (RPKM 27.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B3; 17 19.77 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (44112243..44350407)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (43801352..44039516)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Overexpression of miR-377 Aggravates Sepsis-Induced Myocardial Hypertrophy by Binding to Rcan2 and Mediating CaN Activity.
Title: The Overexpression of miR-377 Aggravates Sepsis-Induced Myocardial Hypertrophy by Binding to Rcan2 and Mediating CaN Activity.
A novel transcriptional complex on the VE-cadherin promoter regulated the downregulation of VE-cadherin in the Down Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis.
Title: A novel transcriptional complex on the VE-cadherin promoter regulated the downregulation of VE-cadherin in the Down Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis.
NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network.
Title: NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network.
RCANs play critical roles in bone homeostasis by regulating both osteoclastogenesis and osteoblastogenesis, and they serve as inhibitors for calcineurin-NFATc1 signaling both in vivo and in vitro.
Title: RCANs regulate the convergent roles of NFATc1 in bone homeostasis.
our results indicate that Rcan2 and estradiol might regulate body weight through different mechanisms in female mice. Rcan2 increases food intake and promotes weight gain, while estradiol increases energy expenditure possibly by regulating physical activity.
Title: Rcan2 and estradiol independently regulate body weight in female mice.
Rcan2 and Rps6kb1 mutations both affect growth and body weight of mice, though likely through different mechanisms
Title: A disputed evidence on obesity: comparison of the effects of Rcan2(-/-) and Rps6kb1(-/-) mutations on growth and body weight in C57BL/6J mice.
Rcan2 regulates osteoblast function and its expression in bone is regulated by thyroid status in vivo
Title: Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function.
an Rcan2-dependent mechanism which regulates food intake and promotes weight gain through a leptin-independent pathway
Title: Inactivation of the Rcan2 gene in mice ameliorates the age- and diet-induced obesity by causing a reduction in food intake.
Genetic inhibition of calcineurin in Zaki-4 transgenic mice induces diastolic dysfunction in mice with chronic pressure overload.
Title: Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:256387 (e-PCR)
- UniSTS:256387

Agtr1b (e-PCR), detects polymorphism
- UniSTS:256387

Rcan2 (e-PCR), detects polymorphism
- UniSTS:499086

Dscr1l1 (e-PCR), detects polymorphism
- UniSTS:186516

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within locomotion involved in locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within short-term memory	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calcipressin-2

Names: Down syndrome critical region gene 1-like 1; calcineurin inhibitory protein ZAKI-4; down syndrome candidate region 1-like protein 1; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286653.1 → NP_001273582.1 calcipressin-2 isoform 1

See identical proteins and their annotated locations for NP_001273582.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 3 and 5 encode the same isoform (1).

Source sequence(s)

AC154204, CT025668

Consensus CDS

CCDS28800.1

UniProtKB/TrEMBL

A0A2R8W6E8, Q8VIP4

Related

ENSMUSP00000039473.6, ENSMUST00000044895.13

Conserved Domains (1) summary

pfam04847
Location:80 → 236

Calcipressin; Calcipressin
NM_001286654.1 → NP_001273583.1 calcipressin-2 isoform 2

See identical proteins and their annotated locations for NP_001273583.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resultign isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Variants 2 and 4 encode the same isoform 2.

Source sequence(s)

CT025668

Consensus CDS

CCDS28801.1

UniProtKB/Swiss-Prot

Q8VIP5, Q9JHG2

UniProtKB/TrEMBL

Q543P2

Related

ENSMUSP00000137211.2, ENSMUST00000177857.9

Conserved Domains (1) summary

pfam04847
Location:22 → 190

Calcipressin
NM_001357742.1 → NP_001344671.1 calcipressin-2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 5 encode the same isoform (1).

Source sequence(s)

AC154204, BC049096, CT025668

Consensus CDS

CCDS28800.1

UniProtKB/TrEMBL

A0A2R8W6E8, Q8VIP4

Related

ENSMUSP00000154835.2, ENSMUST00000228972.2

Conserved Domains (1) summary

pfam04847
Location:80 → 236

Calcipressin; Calcipressin
NM_030598.2 → NP_085101.1 calcipressin-2 isoform 2

See identical proteins and their annotated locations for NP_085101.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Variants 2 and 4 encode the same isoform 2.

Source sequence(s)

BC049096

Consensus CDS

CCDS28801.1

UniProtKB/Swiss-Prot

Q8VIP5, Q9JHG2

UniProtKB/TrEMBL

Q543P2

Related

ENSMUSP00000048013.5, ENSMUST00000044792.6

Conserved Domains (1) summary

pfam04847
Location:22 → 190

Calcipressin
NM_207649.1 → NP_997532.1 calcipressin-2 isoform 1

See identical proteins and their annotated locations for NP_997532.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 3 and 5 encode the same isoform (1).

Source sequence(s)

BB635249, BC049096, BY740155

Consensus CDS

CCDS28800.1

UniProtKB/TrEMBL

A0A2R8W6E8, Q8VIP4

Related

ENSMUSP00000155082.2, ENSMUST00000229744.2

Conserved Domains (1) summary

pfam04847
Location:80 → 236

Calcipressin; Calcipressin