Official Symbol

SUV420H1provided by HGNC

Official Full Name

suppressor of variegation 4-20 homolog 1 (Drosophila)provided by HGNC

Primary Source

HGNC:24283

See related

Ensembl:ENSG00000110066; HPRD:11616; MIM:610881

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

CGI85; KMT5B; CGI-85; MGC703; MGC21161; MGC118906; MGC118909; SUV420H1

Summary

This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 11; Location: 11q13.2See SUV420H1 in MapViewer

Preferred Names

suppressor of variegation 4-20 homolog 1

Names

suppressor of variegation 4-20 homolog 1

C630029K18Rik

OTTHUMP00000197482

OTTHUMP00000197488

NP_057112.3

EC 2.1.1.43

NP_060105.3

EC 2.1.1.43

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_016028.4 → NP_057112.3  suppressor of variegation 4-20 homolog 1 isoform 2

   Description

   Transcript Variant: This variant (2) has an alternate 3' exon and utilizes an upstream stop codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.

   Source sequence(s)

   BC002522,BM152996

   Consensus CDS

   CCDS44660.1

   UniProtKB/Swiss-Prot

   Q4FZB7

   Related Ensembl

   ENSP00000385965, ENSP00000385640, ENST00000401547, ENST00000405515

   Conserved Domains (1) summary

   cl02566
   Location:203 – 307
   Blast Score: 193

   SET; SET domain

2. NM_017635.3 → NP_060105.3  suppressor of variegation 4-20 homolog 1 isoform 1

   Description

   Transcript Variant: This variant (1) encodes the longer isoform (1).

   Source sequence(s)

   AI659791,BC002522,BC012933,BG697990,BM152996,BM719058

   Consensus CDS

   CCDS31623.1

   UniProtKB/Swiss-Prot

   Q4FZB7

   Related Ensembl

   ENSP00000305899, ENST00000304363

   Conserved Domains (1) summary

   cl02566
   Location:203 – 307
   Blast Score: 201

   SET; SET domain

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000011.9

   Range

   67923506..67980783, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_167190.1 

   Range

   13229301..13286578, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000054.1

   Range

   65257584..65291694, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_925106.1 

   Range

   13605660..13639770, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000143.1

   Range

   64258962..64316330

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001838025.2 

   Range

   1086554..1143922

   Download

   GenBank FASTA Sequence Viewer (Graphics)