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1: NOX3 NADPH oxidase 3 [ Homo sapiens ]

GeneID: 50508 updated 4-Dec-2009

[Top][Help]Summary

Official Symbol
NOX3provided by HGNC
Official Full Name
NADPH oxidase 3provided by HGNC
Primary Source
HGNC:7890
See related
Ensembl:ENSG00000074771; HPRD:06165; MIM:607105
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP91-3; NOX3
Summary
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 6; Location: 6q25.1-q26See NOX3 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. Observational study of gene-disease association. (HuGE Navigator)
PubMed 2. Roles for p22phox at several distinct points in the maturation and assembly of a functionally competent Nox3 in the plasma membrane.
PubMed 3. In conclusion, the results demonstrate that NOX3, a reactive oxygen species generating NADPH oxidase, plays an integral role in insulin-induced p42/44 Mitogen-activated protein kinase signal transmission and VEGF-A production.
PubMed 4. Rac1 regulates both oxidases Nox1 and Nox3 through the Nox activators
PubMed 5. Nox3 is regulated by NOXO1, p47phox, and p67phox
PubMed 6. Potential candidate genes in these regions that have been implicated in diabetic nephropathy and/or renal damage in models of hypertension include CYBA (or P22PHOX) (16q24), NOX1 (10q22), and NOX3 (6q25.1-q26).
PubMed 7. Nox3 functions together with p22(phox) as an enzyme constitutively producing superoxide
Submit: New GeneRIF Correction

[Top][Help]HIV-1 protein interactions

Protein    Interaction
1. Envelope surface glycoprotein gp120 HIV-1 gp120 binding to CXCR4 induces NADPH oxidase-mediated production of superoxide radicals in neurons, which is involved in the activation of neutral sphingomyelinase PubMed
2. Envelope surface glycoprotein gp160, precursor HIV-1 gp160 inhibits the cellular immune response and enhances oxidative stress mediated by NADPH oxidase PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

[Top][Help]General gene information

Markers

D6S442(e-PCR), detects polymorphism
Links: UniSTS:13679
D6S442(e-PCR), detects polymorphism
Links: UniSTS:6103

Homology

Homologs of the NOX3 gene The NOX3 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, A.thaliana, and rice.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Leukocyte transendothelial migration
04670

Gene Ontology Provided by GOA

Component Evidence
NADPH oxidase complex IEA   
cytoplasm IEA   
integral to membrane IEA   
membrane IEA   

[Top][Help]General protein information

Preferred Names
NADPH oxidase 3
Names
NADPH oxidase 3
NADPH oxidase catalytic subunit-like 3

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

Genomic

  1. NG_011995.1 RefSeqGene

    Range
    5000..65535
    Download
    GenBank FASTA Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015718.2 → NP_056533.1  NADPH oxidase 3

    Source sequence(s)
    AL031773
    Consensus CDS
    CCDS5250.1
    UniProtKB/Swiss-Prot
    Q9HBY0
    Related Ensembl
    ENSP00000159060, ENST00000159060
    Conserved Domains (9) summary
    COG4097
    Location:7 – 549
    Blast Score: 122
    COG4097; Predicted ferric reductase [Inorganic ion transport and metabolism]
    cd06186
    Location:295 – 568
    Blast Score: 416
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism...
    cl01043
    Location:55 – 218
    Blast Score: 207
    Ferric_reduct; Ferric reductase like transmembrane component
    COG4097
    Location:7 – 549
    Blast Score: 122
    COG4097; Predicted ferric reductase [Inorganic ion transport and metabolism]
    cd06186
    Location:295 – 568
    Blast Score: 416
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism...
    cl01043
    Location:55 – 218
    Blast Score: 207
    Ferric_reduct; Ferric reductase like transmembrane component
    COG4097
    Location:7 – 549
    Blast Score: 122
    COG4097; Predicted ferric reductase [Inorganic ion transport and metabolism]
    cd06186
    Location:295 – 568
    Blast Score: 416
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism...
    cl01043
    Location:55 – 218
    Blast Score: 207
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000006.11

    Range
    155716503..155777036, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_025741.15 

    Range
    59885960..59946493, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000049.1

    Range
    156450815..156511368, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_923184.1 

    Range
    88519419..88579972, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000138.1

    Range
    153278818..153339381
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838990.2 

    Range
    1783516..1844079
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AL031773.1   CAI19957.1
  genomic   CH471051.2   EAW47689.1
  mRNA   AF190122.1   AAG17121.1
  mRNA   AF229177.1   AAG15435.1
  other-genetic   BC160172.1   AAI60172.1
Protein Accession   Links
Q9HBY0.1   GenPept   UniProtKB/Swiss-Prot:Q9HBY0

[Top][Help]Additional Links

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.