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    Zdhhc23 zinc finger, DHHC domain containing 23 [ Mus musculus (house mouse) ]

    Gene ID: 332175, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zdhhc23provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 23provided by MGI
    Primary source
    MGI:MGI:2685625
    See related
    Ensembl:ENSMUSG00000036304 AllianceGenome:MGI:2685625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nidd; Gm779; Gm1751; DHHC-23
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Acts upstream of or within protein localization to plasma membrane and protein palmitoylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including central nervous system; ileum; metanephros; reproductive system; and respiratory system. Orthologous to human ZDHHC23 (zinc finger DHHC-type palmitoyltransferase 23). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 3.6), frontal lobe adult (RPKM 2.7) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B4; 16 28.44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43785396..43800295, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (43965033..43979820, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene queuine tRNA-ribosyltransferase accessory subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E1924 Neighboring gene predicted gene, 25989 Neighboring gene coiled-coil domain containing 191 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43951746-43952047 Neighboring gene predicted gene, 46552 Neighboring gene GRAM domain containing 1C Neighboring gene STARR-seq mESC enhancer starr_40889 Neighboring gene microRNA 3470b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. S-Acylation controls functional coupling of BK channel pore-forming α-subunits and β1-subunits. Duncan PJ, et al. J Biol Chem, 2019 Aug 9. PMID 31213527, Free PMC Article
    2. In a mouse model of INCL reduced S-palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation. Sadhukhan T, et al. J Inherit Metab Dis, 2021 Jul. PMID 33739454
    3. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. Tian L, et al. J Biol Chem, 2012 Apr 27. PMID 22399288, Free PMC Article
    4. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
    5. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC23
    Names
    DHHC-containing protein 11
    nNOS-intereacting DHHC-containing Dem protein-L
    probable palmitoyltransferase ZDHHC23
    zinc finger DHHC domain-containing protein 23
    NP_001007461.1
    NP_001355632.1
    XP_006522374.1
    XP_011244238.1
    XP_017172544.1
    XP_030105025.1
    XP_030105026.1
    XP_036015889.1
    XP_036015890.1
    XP_036015891.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007460.2 → NP_001007461.1  palmitoyltransferase ZDHHC23

      See identical proteins and their annotated locations for NP_001007461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC129306, CT025520
      Consensus CDS
      CCDS28180.1
      UniProtKB/Swiss-Prot
      A6H5Y4, Q3UH65, Q3UVA2, Q5Y5T3
      Conserved Domains (1) summary
      pfam01529
      Location:248 → 374
      DHHC; DHHC palmitoyltransferase

    2. NM_001368703.1 → NP_001355632.1  palmitoyltransferase ZDHHC23

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC129306, AK147553, CT025520
      Consensus CDS
      CCDS28180.1
      UniProtKB/Swiss-Prot
      A6H5Y4, Q3UH65, Q3UVA2, Q5Y5T3
      Related
      ENSMUSP00000156253.2, ENSMUST00000231700.2
      Conserved Domains (1) summary
      pfam01529
      Location:248 → 374
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      43785396..43800295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159996.1 → XP_036015889.1  palmitoyltransferase ZDHHC23 isoform X1

      UniProtKB/Swiss-Prot
      A6H5Y4, Q3UH65, Q3UVA2, Q5Y5T3
      Related
      ENSMUSP00000128650.2, ENSMUST00000165648.2
      Conserved Domains (1) summary
      pfam01529
      Location:248 → 374
      DHHC; DHHC palmitoyltransferase

    2. XM_036159998.1 → XP_036015891.1  palmitoyltransferase ZDHHC23 isoform X4

      Conserved Domains (1) summary
      pfam01529
      Location:210 → 336
      DHHC; DHHC palmitoyltransferase

    3. XM_036159997.1 → XP_036015890.1  palmitoyltransferase ZDHHC23 isoform X2

      UniProtKB/TrEMBL
      B7ZNY8
      Related
      ENSMUSP00000044744.8, ENSMUST00000036321.14
      Conserved Domains (1) summary
      pfam01529
      Location:248 → 371
      DHHC; DHHC palmitoyltransferase

    4. XM_017317055.2 → XP_017172544.1  palmitoyltransferase ZDHHC23 isoform X1

      UniProtKB/Swiss-Prot
      A6H5Y4, Q3UH65, Q3UVA2, Q5Y5T3
      Conserved Domains (1) summary
      pfam01529
      Location:248 → 374
      DHHC; DHHC palmitoyltransferase

    5. XM_006522311.3 → XP_006522374.1  palmitoyltransferase ZDHHC23 isoform X1

      See identical proteins and their annotated locations for XP_006522374.1

      UniProtKB/Swiss-Prot
      A6H5Y4, Q3UH65, Q3UVA2, Q5Y5T3
      Conserved Domains (1) summary
      pfam01529
      Location:248 → 374
      DHHC; DHHC palmitoyltransferase

    6. XM_011245936.2 → XP_011244238.1  palmitoyltransferase ZDHHC23 isoform X2

      See identical proteins and their annotated locations for XP_011244238.1

      UniProtKB/TrEMBL
      B7ZNY8
      Conserved Domains (1) summary
      pfam01529
      Location:248 → 371
      DHHC; DHHC palmitoyltransferase

    7. XM_030249166.1 → XP_030105026.1  palmitoyltransferase ZDHHC23 isoform X3

      UniProtKB/TrEMBL
      B7ZNY9
      Related
      ENSMUSP00000156089.2, ENSMUST00000232055.2
      Conserved Domains (2) summary
      pfam01529
      Location:248 → 337
      DHHC; DHHC palmitoyltransferase
      pfam03203
      Location:90 → 155
      MerC; MerC mercury resistance protein

    8. XM_030249165.1 → XP_030105025.1  palmitoyltransferase ZDHHC23 isoform X2

      UniProtKB/TrEMBL
      B7ZNY8
      Conserved Domains (1) summary
      pfam01529
      Location:248 → 371
      DHHC; DHHC palmitoyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5Y5T3.1 GenPept UniProtKB/Swiss-Prot:Q5Y5T3

    Gene LinkOut

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