Official Symbol

USP25provided by HGNC

Official Full Name

ubiquitin specific peptidase 25provided by HGNC

Primary Source

HGNC:12624

See related

Ensembl:ENSG00000155313; HPRD:05296; MIM:604736

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

USP21; USP25

Summary

Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM]

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chromosome: 21; Location: 21q11.2See USP25 in MapViewer

Preferred Names

ubiquitin specific peptidase 25

Names

ubiquitin specific peptidase 25

deubiquitinating enzyme 25

ubiquitin thiolesterase 25

ubiquitin specific protease 25

ubiquitin carboxyl-terminal hydrolase 25

ubiquitin-specific processing protease 25

NP_037528.3

EC 3.1.2.15

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_013396.3 → NP_037528.3  ubiquitin specific peptidase 25

   Source sequence(s)

   AF134213,AF170562,BI256537,BQ215557

   Consensus CDS

   CCDS33515.1

   UniProtKB/Swiss-Prot

   Q9UHP3

   Related Ensembl

   ENSP00000285679, ENST00000285679

   Conserved Domains (2) summary

   cd02665
   Location:258 – 404
   Blast Score: 575

   Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...

   cl02553
   Location:168 – 297
   Blast Score: 148

   Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000021.8

   Range

   17102495..17252376

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_011512.11 

   Range

   2764366..2914247

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000064.1

   Range

   2272739..2422617

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_927384.1 

   Range

   1757862..1907740

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000153.1

   Range

   2481854..2631588

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001838706.1 

   Range

   1911268..2061002

   Download

   GenBank FASTA Sequence Viewer (Graphics)