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    GPR6 G protein-coupled receptor 6 [ Homo sapiens (human) ]

    Gene ID: 2830, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GPR6provided by HGNC
    Official Full Name
    G protein-coupled receptor 6provided by HGNC
    Primary source
    HGNC:HGNC:4515
    See related
    Ensembl:ENSG00000146360 MIM:600553; AllianceGenome:HGNC:4515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable sphingosine-1-phosphate receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    6q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (109978311..109980720)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (111156757..111159166)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (110299514..110301923)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109828991-109829516 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109829517-109830042 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109834827-109835332 Neighboring gene ZBTB24 divergent transcript Neighboring gene adenylate kinase 9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110000392-110001073 Neighboring gene MPRA-validated peak6018 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24932 Neighboring gene FIG4 phosphoinositide 5-phosphatase Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110176827-110177342 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:110177343-110177858 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:110203046-110204245 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:110214364-110214978 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:110265029-110265927 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:110265928-110266825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110299945-110300750 Neighboring gene uncharacterized LOC107986631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110437149-110437694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110437695-110438238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17466 Neighboring gene WASP family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPR6 Structural Insights: Homology Model Construction and Docking Studies. Isawi IH, et al. Molecules, 2020 Feb 7. PMID 32046081, Free PMC Article
    2. How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis. Collins AG, et al. Eur J Neurosci, 2012 Apr. PMID 22487033, Free PMC Article
    3. Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. Uhlenbrock K, et al. Cell Physiol Biochem, 2003. PMID 12649592
    4. Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. Song ZH, et al. Genomics, 1995 Jul 20. PMID 8530049
    5. Isolation of three novel human genes encoding G protein-coupled receptors. Heiber M, et al. DNA Cell Biol, 1995 Jan. PMID 7832990

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR6 Structural Insights: Homology Model Construction and Docking Studies.
      Title: GPR6 Structural Insights: Homology Model Construction and Docking Studies.
    2. The GPR6 gene influences the reinforcement learning rate in a computational, neurogenetic model.
      Title: How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
    4. control of gene expression in vascular endothelial cells in the presence of fluid shear stress and determines that it is not a sphingosine 1-phosphate receptor
      Title: Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ59257

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables sphingosine-1-phosphate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingosine-1-phosphate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 6
    Names
    sphingosine 1-phosphate receptor GPR6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286099.2 → NP_001273028.1  G-protein coupled receptor 6 isoform a

      See identical proteins and their annotated locations for NP_001273028.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and enocdes the longer isoform (a).
      Source sequence(s)
      AK295250, AL591076, BC043414, DA205492, DA260869
      Consensus CDS
      CCDS69172.1
      UniProtKB/TrEMBL
      E7EP76
      Related
      ENSP00000406986.2, ENST00000414000.3
      Conserved Domains (1) summary
      cd15962
      Location:88 → 355
      7tmA_GPR6; G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_005284.5 → NP_005275.1  G-protein coupled receptor 6 isoform b

      See identical proteins and their annotated locations for NP_005275.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AL591076, BC043414, DA205492, DA260869
      Consensus CDS
      CCDS5079.1
      UniProtKB/Swiss-Prot
      B4DHS9, J3KQR3, P46095, Q17RJ7, Q5SYL0
      UniProtKB/TrEMBL
      E7EP76, F1DAM6
      Related
      ENSP00000275169.3, ENST00000275169.5
      Conserved Domains (1) summary
      cd15962
      Location:73 → 340
      7tmA_GPR6; G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      109978311..109980720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      111156757..111159166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46095.1 GenPept UniProtKB/Swiss-Prot:P46095

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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