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    Mios meiosis regulator for oocyte development [ Mus musculus (house mouse) ]

    Gene ID: 252875, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Miosprovided by MGI
    Official Full Name
    meiosis regulator for oocyte developmentprovided by MGI
    Primary source
    MGI:MGI:2182066
    See related
    Ensembl:ENSMUSG00000042447 AllianceGenome:MGI:2182066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and protein-containing complex localization. Predicted to be located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Predicted to be part of GATOR2 complex. Predicted to be active in cytoplasm. Is expressed in retina. Orthologous to human MIOS (meiosis regulator for oocyte development). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.0), CNS E14 (RPKM 4.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A1; 6 3.51 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (8209111..8240573)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (8209111..8240573)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RNA binding protein with serine rich domain 1, pseudogene Neighboring gene predicted gene, 35446 Neighboring gene collagen, type XXVIII, alpha 1 Neighboring gene predicted gene, 35384 Neighboring gene STARR-seq mESC enhancer starr_15110 Neighboring gene STARR-seq mESC enhancer starr_15111 Neighboring gene STARR-seq mESC enhancer starr_15112 Neighboring gene STARR-positive B cell enhancer ABC_E1064 Neighboring gene STARR-positive B cell enhancer mm9_chr6:8225128-8225429 Neighboring gene UMAP1-MVP12 associated (UMA) domain containing 1 Neighboring gene replication protein A3 Neighboring gene STARR-seq mESC enhancer starr_15115 Neighboring gene STARR-seq mESC enhancer starr_15116 Neighboring gene predicted gene, 46952

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GATOR2 complex-mediated amino acid signaling regulates brain myelination. Yu Z, et al. Proc Natl Acad Sci U S A, 2022 Jan 18. PMID 35022234, Free PMC Article
    2. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
    3. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Lenihan JA, et al. Mol Neurobiol, 2017 Dec. PMID 27889896
    4. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
    5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25527

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system myelin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligodendrocyte progenitor proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of GATOR2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GATOR2 complex protein MIOS
    Names
    GATOR complex protein MIOS
    WD repeat-containing protein mio
    missing oocyte, meiosis regulator, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145374.2 → NP_663349.2  GATOR2 complex protein MIOS

      See identical proteins and their annotated locations for NP_663349.2

      Status: VALIDATED

      Source sequence(s)
      AK034623, AK079844, BP765255, BQ876300, BU510538, BY064617, CD807728, CX565910
      Consensus CDS
      CCDS39425.1
      UniProtKB/Swiss-Prot
      E9QM00, Q8VE19
      Related
      ENSMUSP00000039301.8, ENSMUST00000040017.8
      Conserved Domains (3) summary
      COG2319
      Location:97 → 368
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 105
      7WD40; WD40 repeat [structural motif]
      cd16691
      Location:782 → 858
      mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      8209111..8240573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166131.1 → XP_036022024.1  GATOR2 complex protein MIOS isoform X2

      Conserved Domains (3) summary
      COG2319
      Location:97 → 368
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 105
      7WD40; WD40 repeat [structural motif]
      cd16691
      Location:697 → 791
      mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins

    2. XM_036166132.1 → XP_036022025.1  GATOR2 complex protein MIOS isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:97 → 368
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 105
      7WD40; WD40 repeat [structural motif]
      cd16691
      Location:697 → 773
      mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins

    3. XM_036166130.1 → XP_036022023.1  GATOR2 complex protein MIOS isoform X1

      Conserved Domains (3) summary
      sd00039
      Location:64 → 105
      7WD40; WD40 repeat [structural motif]
      cd16691
      Location:782 → 876
      mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
      cl29593
      Location:112 → 299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_036166129.1 → XP_036022022.1  GATOR2 complex protein MIOS isoform X1

      Conserved Domains (3) summary
      sd00039
      Location:64 → 105
      7WD40; WD40 repeat [structural motif]
      cd16691
      Location:782 → 876
      mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
      cl29593
      Location:112 → 299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_004942957.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE19.2 GenPept UniProtKB/Swiss-Prot:Q8VE19

    Gene LinkOut

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