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    Tenm1 teneurin transmembrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 23963, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Tenm1provided by MGI
    Official Full Name
    teneurin transmembrane protein 1provided by MGI
    Primary source
    MGI:MGI:1345185
    See related
    Ensembl:ENSMUSG00000016150 AllianceGenome:MGI:1345185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Odz1; Odz2; ten-1; TCAP-1; Ten-m1
    Summary
    Enables protein heterodimerization activity and protein homodimerization activity. Involved in positive regulation of cellular component biogenesis; positive regulation of protein phosphorylation; and regulation of transcription by RNA polymerase III. Located in several cellular components, including extracellular region; nucleus; and perinuclear region of cytoplasm. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TENM1 (teneurin transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 5.4), CNS E18 (RPKM 3.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A4; X 23.21 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (41616743..42518045, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (42527866..43429168, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47067 Neighboring gene STARR-seq mESC enhancer starr_47068 Neighboring gene TEX13 family member D Neighboring gene SH2 domain containing 1A Neighboring gene predicted gene, 23705 Neighboring gene STARR-seq mESC enhancer starr_47070 Neighboring gene predicted gene, 46667 Neighboring gene predicted gene 14578 Neighboring gene STARR-seq mESC enhancer starr_47071 Neighboring gene predicted gene, 24763 Neighboring gene STARR-seq mESC enhancer starr_47072 Neighboring gene STARR-seq mESC enhancer starr_47073 Neighboring gene predicted gene 14579 Neighboring gene TEX13 family member C1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells. Trubiani G, et al. Brain Res, 2007 Oct 24. PMID 17900539
    2. Regulation of neurite growth in immortalized mouse hypothalamic neurons and rat hippocampal primary cultures by teneurin C-terminal-associated peptide-1. Al Chawaf A, et al. Neuroscience, 2007 Feb 23. PMID 17174479
    3. Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity. Wang L, et al. Brain Res Mol Brain Res, 2005 Feb 18. PMID 15710242
    4. A role for TENM1 mutations in congenital general anosmia. Alkelai A, et al. Clin Genet, 2016 Sep. PMID 27040985
    5. C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells. Chand D, et al. Mol Cell Neurosci, 2013 Jan. PMID 23026563

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results of our study, that describes a new Tenm1 mouse, agree with the hypothesis that TENM1 has a role in olfaction. However, additional studies should be done in larger Congenital general anosmia (CGA) cohorts, to provide statistical evidence that loss-of-function mutations in TENM1 can solely cause the disease in our and other CGA cases
      Title: A role for TENM1 mutations in congenital general anosmia.
    2. Our data provides novel evidence that TCAP-1 is structurally and functionally distinct from the larger teneurins
      Title: C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells.
    3. Our data provides novel evidence that functionally links the teneurin and dystroglycan systems and provides new insight into the molecular mechanisms by which TCAP-1 regulates cytoskeletal dynamics in hippocampal neurons
      Title: C-Terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an extracellular signal-regulated kinase-dependent stathmin- and filamin A-mediated mechanism in hippocampal cells.
    4. The TCAP-1 induces a significant decline in BDNF transcription and protein labeling in embyronic mouse immortalized hypothalamic neurons.
      Title: Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells.
    5. TCAP-1 attenuated the corticotropin-releasing factor (CRF)-induced increase in c-Fos expression in the limbic system: TCAP-1 may play a potential role in the stress regulation by blocking CRF-mediated activity in stress-sensitive areas of the brain
      Title: Teneurin C-terminal associated peptide (TCAP)-1 attenuates corticotropin-releasing factor (CRF)-induced c-Fos expression in the limbic system and modulates anxiety behavior in male Wistar rats.
    6. Thus, the TCAP-teneurin system may be part of a mechanism to protect neurons during trauma, such as hypoxia and ischemia.
      Title: Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells.
    7. These data suggest that TCAP acts, in part, as a functional region of the teneurins to regulate neurite and axonal growth of neurons.
      Title: Regulation of neurite growth in immortalized mouse hypothalamic neurons and rat hippocampal primary cultures by teneurin C-terminal-associated peptide-1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    teneurin-1
    Names
    protein Odd Oz/ten-m homolog 1
    tenascin-M1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011855.4 → NP_035985.2  teneurin-1

      See identical proteins and their annotated locations for NP_035985.2

      Status: VALIDATED

      Source sequence(s)
      AL831716, BC138860, BY729750
      Consensus CDS
      CCDS40953.1
      UniProtKB/Swiss-Prot
      Q8CAT1, Q9WTS4
      UniProtKB/TrEMBL
      A2ANM0
      Related
      ENSMUSP00000016294.8, ENSMUST00000016294.8
      Conserved Domains (8) summary
      COG3209
      Location:1824 → 2393
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1196 → 1235
      NHL; NHL repeat [structural motif]
      pfam07974
      Location:662 → 689
      EGF_2; EGF-like domain
      cl18310
      Location:1196 → 1527
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01414
      Location:709 → 751
      DSL; Delta serrate ligand
      pfam05593
      Location:1643 → 1677
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2647 → 2724
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      41616743..42518045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318483.2 → XP_017173972.1  teneurin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CAT1, Q9WTS4
      UniProtKB/TrEMBL
      A2ANM0
      Conserved Domains (8) summary
      COG3209
      Location:1824 → 2393
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1196 → 1235
      NHL; NHL repeat [structural motif]
      pfam07974
      Location:662 → 689
      EGF_2; EGF-like domain
      cl18310
      Location:1196 → 1527
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01414
      Location:709 → 751
      DSL; Delta serrate ligand
      pfam05593
      Location:1643 → 1677
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2647 → 2724
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    2. XM_011251006.4 → XP_011249308.1  teneurin-1 isoform X1

      See identical proteins and their annotated locations for XP_011249308.1

      UniProtKB/Swiss-Prot
      Q8CAT1, Q9WTS4
      UniProtKB/TrEMBL
      A2ANM0
      Related
      ENSMUSP00000110711.2, ENSMUST00000115059.8
      Conserved Domains (8) summary
      COG3209
      Location:1824 → 2393
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1196 → 1235
      NHL; NHL repeat [structural motif]
      pfam07974
      Location:662 → 689
      EGF_2; EGF-like domain
      cl18310
      Location:1196 → 1527
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01414
      Location:709 → 751
      DSL; Delta serrate ligand
      pfam05593
      Location:1643 → 1677
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2647 → 2724
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    3. XM_006541491.5 → XP_006541554.1  teneurin-1 isoform X2

      Conserved Domains (8) summary
      COG3209
      Location:1823 → 2392
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1195 → 1234
      NHL; NHL repeat [structural motif]
      pfam07974
      Location:661 → 688
      EGF_2; EGF-like domain
      cl18310
      Location:1195 → 1526
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01414
      Location:708 → 750
      DSL; Delta serrate ligand
      pfam05593
      Location:1642 → 1676
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2646 → 2723
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    4. XM_006541492.5 → XP_006541555.1  teneurin-1 isoform X3

      UniProtKB/TrEMBL
      A2ANL9
      Related
      ENSMUSP00000110710.2, ENSMUST00000115058.8
      Conserved Domains (8) summary
      COG3209
      Location:1817 → 2386
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1196 → 1225
      NHL; NHL repeat [structural motif]
      pfam07974
      Location:662 → 689
      EGF_2; EGF-like domain
      cl18310
      Location:1196 → 1520
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01414
      Location:709 → 751
      DSL; Delta serrate ligand
      pfam05593
      Location:1636 → 1670
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2640 → 2717
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    5. XM_011251005.4 → XP_011249307.1  teneurin-1 isoform X1

      See identical proteins and their annotated locations for XP_011249307.1

      UniProtKB/Swiss-Prot
      Q8CAT1, Q9WTS4
      UniProtKB/TrEMBL
      A2ANM0
      Conserved Domains (8) summary
      COG3209
      Location:1824 → 2393
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1196 → 1235
      NHL; NHL repeat [structural motif]
      pfam07974
      Location:662 → 689
      EGF_2; EGF-like domain
      cl18310
      Location:1196 → 1527
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01414
      Location:709 → 751
      DSL; Delta serrate ligand
      pfam05593
      Location:1643 → 1677
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2647 → 2724
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    6. XM_017318484.3 → XP_017173973.1  teneurin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CAT1, Q9WTS4
      UniProtKB/TrEMBL
      A2ANM0
      Conserved Domains (8) summary
      COG3209
      Location:1824 → 2393
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1196 → 1235
      NHL; NHL repeat [structural motif]
      pfam07974
      Location:662 → 689
      EGF_2; EGF-like domain
      cl18310
      Location:1196 → 1527
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01414
      Location:709 → 751
      DSL; Delta serrate ligand
      pfam05593
      Location:1643 → 1677
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2647 → 2724
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    7. XM_011251007.4 → XP_011249309.1  teneurin-1 isoform X1

      See identical proteins and their annotated locations for XP_011249309.1

      UniProtKB/Swiss-Prot
      Q8CAT1, Q9WTS4
      UniProtKB/TrEMBL
      A2ANM0
      Conserved Domains (8) summary
      COG3209
      Location:1824 → 2393
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1196 → 1235
      NHL; NHL repeat [structural motif]
      pfam07974
      Location:662 → 689
      EGF_2; EGF-like domain
      cl18310
      Location:1196 → 1527
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01414
      Location:709 → 751
      DSL; Delta serrate ligand
      pfam05593
      Location:1643 → 1677
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2647 → 2724
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTS4.1 GenPept UniProtKB/Swiss-Prot:Q9WTS4

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