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    Tex261 testis expressed gene 261 [ Mus musculus (house mouse) ]

    Gene ID: 21766, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tex261provided by MGI
    Official Full Name
    testis expressed gene 261provided by MGI
    Primary source
    MGI:MGI:1096575
    See related
    Ensembl:ENSMUSG00000014748 AllianceGenome:MGI:1096575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TEG-261; 3110001O07Rik
    Summary
    Predicted to enable COPII receptor activity. Acts upstream of or within positive regulation of apoptotic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle. Predicted to be integral component of Golgi membrane and integral component of endoplasmic reticulum membrane. Is expressed in testis. Orthologous to human TEX261 (testis expressed 261). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 63.8), ovary adult (RPKM 52.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 C3; 6 35.94 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83745863..83752804, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83768881..83776099, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700124L16 gene Neighboring gene ankyrin repeat domain 53 Neighboring gene predicted gene, 52907 Neighboring gene 60S ribosomal protein L27 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tex261 modulates the excitotoxic cell death induced by N-methyl-D-aspartate (NMDA) receptor activation. Taniura H, et al. Biochem Biophys Res Commun, 2007 Nov 3. PMID 17803966
    2. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. López-Fernández LA, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464256
    3. Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. López-Fernández LA, et al. Mamm Genome, 1996 Sep. PMID 8703127
    4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    5. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings suggest that Tex261 modulates the excitotoxic cell death induced by NMDA receptor activation.
      Title: Tex261 modulates the excitotoxic cell death induced by N-methyl-D-aspartate (NMDA) receptor activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables COPII receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein TEX261
    Names
    testis-expressed protein 261
    testis-expressed sequence 261 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009357.2 → NP_033383.1  protein TEX261

      See identical proteins and their annotated locations for NP_033383.1

      Status: VALIDATED

      Source sequence(s)
      AK149789, BB526853, BY250528
      Consensus CDS
      CCDS20285.1
      UniProtKB/Swiss-Prot
      Q62302
      Related
      ENSMUSP00000014892.7, ENSMUST00000014892.8
      Conserved Domains (1) summary
      pfam04148
      Location:1 → 186
      Erv26; Transmembrane adaptor Erv26

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      83745863..83752804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505886.4 → XP_006505949.1  protein TEX261 isoform X1

      See identical proteins and their annotated locations for XP_006505949.1

      Conserved Domains (1) summary
      pfam04148
      Location:1 → 139
      Erv26; Transmembrane adaptor Erv26

    2. XM_006505888.5 → XP_006505951.1  protein TEX261 isoform X2

      Conserved Domains (1) summary
      pfam04148
      Location:1 → 123
      Erv26; Transmembrane adaptor Erv26

    3. XM_030255311.1 → XP_030111171.1  protein TEX261 isoform X1

      Conserved Domains (1) summary
      pfam04148
      Location:1 → 139
      Erv26; Transmembrane adaptor Erv26
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62302.1 GenPept UniProtKB/Swiss-Prot:Q62302

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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