Official Symbol: Kdm5aprovided by MGI
Official Full Name: lysine (K)-specific demethylase 5Aprovided by MGI
Primary Source: MGI:2136980
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus
Also known as: RBP2; Rbbp2; C76986; Jarid1a; AA409370; MGC11659; Kdm5a

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence details Try our new Sequence Viewer

[Top][Help]Genomic context

chromosome: 6; Location: 6 F1See Kdm5a in MapViewer

[Top][Help]Bibliography

GeneRIFs: Gene References Into Function What's a GeneRIF?

	1.	A functional interplay between the PRC2 complex and the H3K4me3 demethylase Rbp2 (Jarid1a) in mouse embryonic stem (ES) cells.
	2.	mutation can downregulate cardiac cell proliferation by repressing cyclin D1 expression in the same way as jumonji

Submit: New GeneRIF Correction

[Top][Help]General gene information

Markers

NoName(e-PCR): Links: UniSTS:235543

RH142775(e-PCR): Links: UniSTS:232022

RH124853(e-PCR): Links: UniSTS:161675

RH126075(e-PCR): Links: UniSTS:162787

Genotypes

See Kdm5a SNP Genotype Report

See Kdm5a SNP Geneview Report

Homology

Homologs of the Kdm5a gene The Kdm5a gene is conserved in human, dog, cow, chicken, fruit fly, and mosquito.

Map Viewer (Human)

Gene Ontology Provided by GOA

Function	Evidence
DNA binding	IEA
iron ion binding	IEA
metal ion binding	IEA
oxidoreductase activity	IEA
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA
protein binding	IEA
zinc ion binding	IEA

Process	Evidence
chromatin modification	IEA
multicellular organismal development	IEA
oxidation reduction	IEA
regulation of transcription	IEA
transcription	IEA

Component	Evidence
intracellular	IEA
nucleus	IEA

[Top][Help]General protein information

Preferred Names: lysine (K)-specific demethylase 5A

Names: lysine (K)-specific demethylase 5A; retinoblastoma binding protein 2; jumonji, AT rich interactive domain 1A (Rbp2 like)

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

NM_145997.2 → NP_666109.2 lysine (K)-specific demethylase 5A

Source sequence(s)

AC078896,AC155720

UniProtKB/Swiss-Prot

Q3UXZ9

Conserved Domains (6) summary

pfam02373
Location:470 – 586
Blast Score: 478

JmjC; JmjC domain

pfam02928
Location:676 – 729
Blast Score: 238

zf-C5HC2; C5HC2 zinc finger

pfam08429
Location:740 – 1072
Blast Score: 958

PLU-1; PLU-1-like protein

cl02530
Location:295 – 343
Blast Score: 168

PHD; PHD-finger

cl02633
Location:81 – 189
Blast Score: 351

ARID; ARID/BRIGHT DNA binding domain

cl02654
Location:25 – 59
Blast Score: 151

JmjN; jmjN domain

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (C57BL/6J)

Genomic

NC_000072.5

Range

120312353..120394591

Download

GenBank FASTA Sequence Viewer (Graphics)
NT_039353.7

Range

72625315..72707553

Download

GenBank FASTA Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_359326.6 → XP_359326.5

Conserved Domains (6) summary

pfam02373
Location:470 – 586
Blast Score: 478

JmjC; JmjC domain

pfam02928
Location:676 – 729
Blast Score: 238

zf-C5HC2; C5HC2 zinc finger

pfam08429
Location:740 – 1072
Blast Score: 958

PLU-1; PLU-1-like protein

cl02530
Location:295 – 343
Blast Score: 168

PHD; PHD-finger

cl02633
Location:81 – 189
Blast Score: 351

ARID; ARID/BRIGHT DNA binding domain

cl02654
Location:25 – 59
Blast Score: 151

JmjN; jmjN domain

Alternate assembly (based on Celera)

Genomic

AC_000028.1

Range

122199094..122281398

Download

GenBank FASTA Sequence Viewer (Graphics)
NW_001030811.1

Range

61995221..62077525

Download

GenBank FASTA Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_925213.3 → XP_930306.3

Conserved Domains (6) summary

pfam02373
Location:470 – 586
Blast Score: 478

JmjC; JmjC domain

pfam02928
Location:676 – 729
Blast Score: 238

zf-C5HC2; C5HC2 zinc finger

pfam08429
Location:740 – 1072
Blast Score: 958

PLU-1; PLU-1-like protein

cl02530
Location:295 – 343
Blast Score: 168

PHD; PHD-finger

cl02633
Location:81 – 189
Blast Score: 351

ARID; ARID/BRIGHT DNA binding domain

cl02654
Location:25 – 59
Blast Score: 151

JmjN; jmjN domain

Alternate assembly (129/Sv)

Genomic

NT_039382.3

Range

568713..633275, complement

Download

GenBank FASTA Sequence Viewer (Graphics)

mRNA and Protein(s)

XP_984690.2 Peptide Sequence

[Top][Help]Related Sequences

Nucleotide		Protein	Strain
genomic	AC018559.31 (2748..62522)	None	129/Sv
genomic	AC078896.23 (55060..56473)	None	C57BL/6J
genomic	AC155720.7 (134249..210210)	None
mRNA	AK035270.1	None	C57BL/6J
mRNA	AK040260.1	None	C57BL/6J
mRNA	AK041568.1	BAE20593.1	C57BL/6J
mRNA	AK043170.1	None	C57BL/6J
mRNA	AK045999.1	None	C57BL/6J
mRNA	AK046187.1	None	C57BL/6J
mRNA	AK052087.1	None	C57BL/6J
mRNA	AK133589.1	BAE21737.1	C57BL/6J
mRNA	AK134200.1	BAE22050.1	C57BL/6J
mRNA	AK135085.1	BAE22414.1	C57BL/6J
mRNA	AK139619.1	BAE24083.1	C57BL/6J
mRNA	AK140046.1	None	C57BL/6J
mRNA	AK144877.1	BAE26113.1
mRNA	AK154025.1	BAE32322.1	NOD
mRNA	AK159079.1	None	CD-1
mRNA	AK166055.1	BAE38548.1
mRNA	BC010717.1	AAH10717.1	FVB/N
mRNA	BC011506.3	None	CZECHII
mRNA	BC022581.1	None
mRNA	BC080691.1	AAH80691.1	C57BL/6J

Protein Accession	Links
Q3U4V8	GenPept	UniProtKB/TrEMBL:Q3U4V8
Q3UT97	GenPept	UniProtKB/TrEMBL:Q3UT97
Q3UXZ9.2	GenPept	UniProtKB/Swiss-Prot:Q3UXZ9
Q3UZ11	GenPept	UniProtKB/TrEMBL:Q3UZ11
Q3V3E9	GenPept	UniProtKB/TrEMBL:Q3V3E9
Q921T5	GenPept	UniProtKB/TrEMBL:Q921T5