Official Symbol

Itsn2provided by MGI

Official Full Name

intersectin 2provided by MGI

Primary Source

MGI:1338049

See related

Ensembl:ENSMUSG00000020640

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Mus musculus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus

Also known as

Ese2; Sh3d1B; Sh3p18; AI327390; mKIAA1256; Itsn2

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chromosome: 12; Location: 12 A1.1See Itsn2 in MapViewer

Preferred Names

SH3 domain protein 1B

Names

SH3 domain protein 1B

Eh domain, SH3 domain regulator of endocytosis 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_011365.2 → NP_035495.2  SH3 domain protein 1B

   Source sequence(s)

   AF132479,AK034367,BC037119,BE650375,BI872589,CA556907

   Consensus CDS

   CCDS36398.1

   UniProtKB/Swiss-Prot

   Q9Z0R6

   Related Ensembl

   ENSMUSP00000052758, ENSMUST00000062580

   Conserved Domains (7) summary

   cd00030
   Location:1531 – 1619
   Blast Score: 218

   C2; Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol...

   cd00052
   Location:249 – 315
   Blast Score: 220

   EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+...

   cd00160
   Location:1171 – 1354
   Blast Score: 369

   RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

   cd00174
   Location:1092 – 1143
   Blast Score: 187

   SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization...

   smart00027
   Location:15 – 107
   Blast Score: 265

   EH; Eps15 homology domain

   TIGR02168
   Location:481 – 676
   Blast Score: 162

   SMC_prok_B; chromosome segregation protein SMC, common bacterial type

   cl00273
   Location:1396 – 1504
   Blast Score: 122

   PH-like; Pleckstrin homology-like domain. This family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference assembly (C57BL/6J)

Genomic

1. NC_000078.5

   Range

   4599813..4720757

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_039548.7 

   Range

   1599813..1720757

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (based on Celera)

Genomic

1. AC_000034.1

   Range

   4524712..4645574

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001030488.1 

   Range

   1524712..1645574

   Download

   GenBank FASTA Sequence Viewer (Graphics)