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This manuscript demonstrates a unique role for CAR in the AV-node related to localization of connexin 45 to the cell-cell junction. Atrioventricular node block occurs in the absence CAR. |
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These results demonstrate a critical function for coxsackievirus and adenovirus receptor in the pathogenesis of group B coxsackievirus infection in vivo and in virus tropism for the heart and pancreas. |
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it is proposed that adenovirus CAV-2 transport in motor neuron is dictated by an innate trafficking of CAR, suggesting an unsuspected function for this adhesion protein during neuronal homeostasis |
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Results indicate that CAR is not only relevant for virus uptake and cardiac remodeling but also has a previously unknown function in the propagation of excitation from the atrium to the ventricle. |
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Systemic delivery of PEGPE-adenovirus complex is an effective tool of adenoviral delivery as it overcomes limitation due to CAR deficiency of target cells while reducing hepatic uptake and enhancing adenoviral gene expression in tumors. |
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CAR mediates atrioventricular-node function in the murine heart. |
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Activation of STAT1 protein is an early event in coxsackievirus-induced myocarditis preceding enhanced CAR expression during tissue reorganization. |
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A function for CAR in testis morphogenesis and in migration of germ cells across the blood-testis barrier during spermatogenesis. |
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present work shows that stable and transient expression of CAR in tumor cells reduced lung metastasis in an experimental lung metastasis model; CAR expression likely acts as a metastatic suppressor |
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The mCAR gene is situated on the distal portion of murine chromosome 16, and is composed of at least eight exons, with intron-exon boundaries similar to those reported for the human CAR gene |
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Coxsackievirus and adenovirus receptor (CAR) is found in complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX) |
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During a specific temporal window, CAR expression on cardiomyocytes is essential for normal cardiac development. |
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Review: Receptor for the group B coxsackieviruses and adenoviruses, CAR |
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CAR provides positive survival signals to cardiomyocytes that are essential for normal heart development. |
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CAR is an immunoglobulin domain-containing protein that bears homology to cell-adhesion molecules suggesting the possibility that it may participate in organization of the developing olfactory system. |
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Overexpression of CAR may lead to physiological dysfunction by disturbing sarcolemmal integrity (through dystrophin deficiency), impairing sarcolemmal repair (through dysferlin deficiency), and interfering with normal signaling . |
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CAR is a partner in a protein complex organized at specific subcellular sites by Ligand-of-Numb Protein-X2 |
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18. |
Attachment of mouse adenovirus type 1 (MAV-1) to Chinese hamster ovary (CHO) cells was not increased by stable transfection with mouse CAR, whereas binding efficiency of Ad2 was 20-fold higher in the mouse CAR-transfectant compared to wild type cells. |