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1: IPO5 importin 5 [ Homo sapiens ]

GeneID: 3843 updated 3-Dec-2009

[Top][Help]Summary

Official Symbol
IPO5provided by HGNC
Official Full Name
importin 5provided by HGNC
Primary Source
HGNC:6402
Locus Tag
RP11-72J7.1
See related
Ensembl:ENSG00000065150; HPRD:03597; MIM:602008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMB3; KPNB3; RANBP5; MGC2068; FLJ43041; DKFZp686O1576; IPO5
Summary
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 13; Location: 13q32.2See IPO5 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells.
PubMed 2. These results suggest that karyopherin beta3 plays a crucial role in apo A-I secretion.
PubMed 3. Lack of association of the KPNB3 locus in schizophrenia.
PubMed 4. HPV-16 E5 protein binds to karyopherin beta3.
PubMed 5. Observational study of gene-disease association. (HuGE Navigator)
PubMed 6. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
PubMed 7. The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia.
PubMed 8. The KPNB3 locus may contain a disease-causing variant for schizophrenia.
PubMed 9. HPV16 L2 interacts via its NLSs with a network of karyopherins and can enter the nucleus via several import pathways mediated by Kapalpha(2)beta(1) heterodimers, Kapbeta(2), and Kapbeta(3).
PubMed 10. L1 major capsid protein of human papillomavirus type 11 interacts with Kap beta3 nuclear import receptors
PubMed 11. RanBP5 acts as an import factor for the newly synthesized influenza A virus RNA-dependent-RNA polymerase by targeting the PB1-PA dimer to the nucleus.
Submit: New GeneRIF Correction

[Top][Help]HIV-1 protein interactions

Protein    Interaction
1. Rev importin beta can inhibit the interaction of HIV-1 Rev with HIV-1 RRE RNA PubMed
2. importin beta specifically binds to the Rev nuclear localization signal (NLS, amino acids 35-50) and mediates the nuclear import of Rev PubMed
3. Tat The binding of HIV-1 Tat with importin beta is inhibited by RanGTP PubMed
4. Importin beta binds to the HIV-1 Tat protein nuclear localization signal (NLS; amino acids 49-57) and mediates the nuclear import of Tat through a novel import pathway PubMed
5. Vpr HIV-1 Vpr co-localizes with karyopherin beta and regulates karyopherin beta-mediated docking of the HIV-1 preintegration complex at the nuclear envelope, however multiple reports indicate the two proteins do not directly interact PubMed
6. integrase Some reports indicate a possible role for the interactions between karyopherin alpha and beta with HIV-1 integrase in the nuclear import of HIV-1 preintegration complexes (PIC), while other reports indicate integrase is not involved in PIC nuclear import PubMed
7. Karyopherin beta binds to complexes between HIV-1 integrase (integrase/GST fusion protein) and karyopherin alpha, but not to integrase alone PubMed
8. Karyopherin alpha and beta are reported to interact with HIV-1 integrase (IN) to facilitate nuclear import of IN, however a conflicting report indicates nuclear accumulation of IN does not involve karyopherin alpha, beta 1, or beta 2 mediated pathways PubMed
9. matrix Karyopherin beta mediates the nuclear import of HIV-1 preintegration complexes through karyopherin alpha, which binds directly to nuclear localization signals in HIV-1 Matrix PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
Hepatitis C virus (HCV) nonstructural protein 5A interacts with karyopherin beta 3.
  NP_002262.3   NP_751927.1   HCVgp1      BIND    PubMed
 
  NP_002262.3   NP_005115.2   NUP153      HPRD    PubMed
 
  NP_002262.3   NP_005076.3   NUP214      HPRD    PubMed
 
  NP_002262.3   NP_057404.2   NUP98      HPRD    PubMed
 
  NP_002262.3   NP_000527.1   RAG2      HPRD    PubMed
 
  NP_002262.3   NP_006316.1   RAN      HPRD    PubMed
 
  NP_002262.3   NP_006258.2   RANBP2      HPRD    PubMed
 
  NP_002262.3   Ribosomal protein L5   RPL5      HPRD    PubMed
 
  NP_002262.3   Ribosomal protein S7   RPS7      HPRD    PubMed
 
  NP_002262.3   Nup153        HPRD    PubMed
 
  NP_002262.3   RL13        HPRD    PubMed
 
  NP_002262.3   RL23        HPRD    PubMed
 
  NP_002262.3   p62        HPRD    PubMed
 
  NP_002262.3   rpL23a        HPRD    PubMed
Reconstituted Complex
  BioGRID:110041   BioGRID:115297   NUP153      BioGRID    PubMed
Reconstituted Complex
  BioGRID:110041   BioGRID:113717   NUP214      BioGRID    PubMed
Reconstituted Complex
  BioGRID:110041   BioGRID:111837   RAN      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:110041   BioGRID:112067   RPL23A      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:110041   BioGRID:112606   SRP19      BioGRID    PubMed

[Top][Help]General gene information

Markers

RH44720(e-PCR)
Links: UniSTS:48644
GDB:434012(e-PCR)
Links: UniSTS:157204
STS-N89596(e-PCR)
Links: UniSTS:17943
D8S2278(e-PCR)
Links: UniSTS:473906
D8S2279(e-PCR)
Links: UniSTS:473907
SHGC-85098(e-PCR)
Links: UniSTS:103476
STS-D29365(e-PCR)
Links: UniSTS:76362
L18426(e-PCR)
Links: UniSTS:34648
RH15609(e-PCR)
Links: UniSTS:84580
SHGC-80892(e-PCR)
Links: UniSTS:102535
D11S3114(e-PCR)
Links: UniSTS:152207
KPNB3_1159(e-PCR)
Links: UniSTS:277442
D13S853E(e-PCR)
Links: UniSTS:151519
SGC33733(e-PCR)
Links: UniSTS:42975

Homology

Homologs of the IPO5 gene The IPO5 gene is conserved in chimpanzee, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, rice, and P.falciparum.


Map Viewer (Mouse, Rat)

[Top][Help]General protein information

Preferred Names
importin 5
Names
importin 5
RAN binding protein 5
importin beta-3 subunit
Ran_GTP binding protein 5
karyopherin (importin) beta 3

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_002271.4 → NP_002262.3  importin 5

    Source sequence(s)
    AF339834,AK125031,AL705630,BC000947,BC001497,BC045640,BM666295,BU618294,Y08890
    Consensus CDS
    CCDS31999.1
    UniProtKB/TrEMBL
    B3KWG6
    UniProtKB/Swiss-Prot
    O00410
    UniProtKB/TrEMBL
    Q9BVS9
    Related Ensembl
    ENSP00000261574, ENST00000261574
    Conserved Domains (2) summary
    COG5215
    Location:31 – 652
    Blast Score: 180
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    pfam02985
    Location:411 – 445
    Blast Score: 96
    HEAT; HEAT repeat

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000013.10

    Range
    98605928..98676549
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_009952.14 

    Range
    11695604..11766225
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000056.1

    Range
    79453340..79523963
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_925517.1 

    Range
    11706541..11777164
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000145.1

    Range
    79203817..79274125, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838084.2 

    Range
    13683641..13753949, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AL137120.13   CAI16520.1
  genomic   AL356580.13   CAI13757.1
       CAI13758.1
       CAI13759.1
  genomic   CH471085.1   EAX08977.1
       EAX08978.1
       EAX08979.1
       EAX08980.1
       EAX08981.1
  mRNA   AF339834.1   None
  mRNA   AK125031.1   BAG54128.1
  mRNA   AK225286.1   None
  mRNA   AK302812.1   BAG64012.1
  mRNA   AK303494.1   BAG64528.1
  mRNA   AL705630.1   None
  mRNA   BC000947.2   AAH00947.1
  mRNA   BC001497.2   AAH01497.1
  mRNA   BC019309.1   AAH19309.1
  mRNA   BC045640.1   AAH45640.1
  mRNA   BM666295.1   None
  mRNA   BU618294.1   None
  mRNA   BX648222.1   None
  mRNA   CR609014.1   None
  mRNA   U72761.1   AAC51317.1
  mRNA   Y08890.1   CAA70103.1
  other-genetic   DQ893033.2   ABM83959.1
  other-genetic   EU176755.1   ABW03556.1
Protein Accession   Links
O00410.4   GenPept   UniProtKB/Swiss-Prot:O00410
Q5T576   GenPept   UniProtKB/TrEMBL:Q5T576
Q5T577   GenPept   UniProtKB/TrEMBL:Q5T577
Q9BVS9   GenPept   UniProtKB/TrEMBL:Q9BVS9

[Top][Help]Additional Links

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