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1. |
Data show that mice express human CEA, present epitopes solely through HLA-A2.1 molecules and constitute a unique in vivo animal model to study HLA-A2.1-restricted immune response of a human CEA-based vaccine. |
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2. |
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) |
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3. |
These results are congruent with historical sources and other genetic studies that support the finding that the Guinea-Bissau genetic pool was influenced by several migrations from North Africa, Sahara and East Africa. |
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4. |
DRB1*15 increased the risk of developing multiple sclerosis and HLA-A*02 decreased the risk |
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5. |
Observational study and genome-wide association study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
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6. |
The frequency of expressed HLA-A24 in malaria-exposed and non-malaria-exposed healthy adults living in northwest and central Thailand was 90% (27/30) and 100% (12/12), respectively |
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7. |
Stimulation with IFN-gamma and/or TNF-alpha led to an increase of HLA-A*3014L secretion to a detectable level and increased HLA-A*3001 expression up to 8-fold. |
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8. |
HLA-A upregulation in liver cancer was mediated by both increased nuclear aggregation of transcription factor p65 and upregulation of transcription factor IRF-1. |
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9. |
Endogenous HLA-A1 and -A66 as well as transfected HLA-A2 heavy chains in beta 2-microglobulin-defective Burkitt lymphoma Daudi cells are capable of being expressed on the tumor cell surface, although at low levels, and exclusively as immature glycoforms. |
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10. |
HLA-A * 02, HLA-B * 58 and HLA-DRB1 * 03 might be the susceptible genes of NPC patients while HLA-B * 40 might be the protective gene of NPC patients. |
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11. |
HLA-A01 alleles in Han population, Gansu province seem to contribute to the genetic susceptibility, while HLA-A11 and -DR03 alleles to the genetic resistance, to leukemia. |
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12. |
No significant differences of these allelic frequencies were found between the patients and the control subjects, suggesting that the HLA-A gene was unlikely a major risk factor of schizophrenia in Han Chinese from Taiwan. |
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13. |
The binding affinity of HLA-A epitopes is significantly higher than that of HLA-B epitopes and gives rise to new hypotheses concerning the mechanisms underlying immunodominance of CD8-positive T cell responses against intracellular infectious agents. |
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14. |
The distribution of HLA-A, -B allele polymorphism in the Luoba nationality is distinctive, but some of the gene distribution in the Luoba group is nearer to that in the Tibetan group. |
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15. |
A novel allele of HLA-A has been identified and officially named HLA-A*3308 by standard of the WHO Nomenclature Committee. |
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16. |
A biochemical HLA-A*3001 binding assay & a large panel of nonamer peptides & peptide libraries demonstrated that the specificity of HLA-A*3001 most closely resembles that of the HLA-A3 supertype. |
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17. |
HLA-A allele frequency distributions were consistent with the Hardy-Weinberg equilibrium in a group of indigenous Hans in Shenyang, China. |
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18. |
The HLA-DRB1 loci are highly polymorphic in Monba population of Xizang Autonomous Region. Compared with other ethnic groups in China, the Monba ethnic group is close to Tibetan ethnic group. |
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19. |
The HLA-A,-B,-DRB1 distribution in Shanxi Han population shares some genetic characteristics with other Han populations in northern part of China, but it exhibits its own characteristics. |
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20. |
We investigated the genetic polymorphisms of HLA-A, B, DRB1 alleles and haplotype frequencies in Mongols from Inner Mongolia, China. |
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21. |
Guangdong Han population in China has twelve HLA-A, 23 B, 11 Cw and 13 DRB1 alleles and a total of 9 HLA-A-B, 20 Cw-B, 7 A-Cw, and 8 A-DRB1, 9 B-DRB1, 10 Cw-DRB1 haplotypes. |
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22. |
In a northwest Chinese Han population, fifteen alleles for the locus HLA-A, 28 alleles for the HLA-B locus and 13 alleles for the HLA-DRB1 were detected. The results showed that the most frequent HLA alleles found were A02, B13, and DRB1*15. |
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23. |
results suggest that HLA genotype relates to the muscular necrosis and the pathogenesis of Duchenne muscular dystrophy |
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24. |
The human versions of HLA-A*0201 , differing from the murine peptides by only a single residue, represent a candidate to explore as CD8(+) T-cell targets in HLA-A*0201-positive type 1 diabetic patients. |
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25. |
Depleting AP-2 potentiates Nef activity by altering the membrane composition and dynamics of endosomes and causing increased delivery of HLA-A2 to a prelysosomal compartment. |
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26. |
HLA allele and haplotype frequencies in addition to phylogenetic tree and principal component analyses based on the four-digit sequence-level allele frequencies for HLA-A, HLA-B, and HLA-DRB1 showed that Western Javanese was closest to Southeast Asians. |
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27. |
HLA-A mRNA levels may provide an effective and reliable indicator to predict acute rejection episodes in renal transplantation. |
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28. |
We found a significantly higher frequency of the alleles HLA-A1, HLA-A26 and HLA-DR11 in renal cell carcinoma patients compared to the control group. |
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29. |
HLA-A may be involved in the pathogenesis of Alzheimer's disease |
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30. |
HLA-A33 gene is most significantly susceptible to enterovirus 71. |
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31. |
All HLA-A2-positive patients expressed the HLA-A*0201 allele as determined by high resolution typing |
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32. |
In lung transplaant patients HLA-A3 was strongly linked to post-transplant lymphoproliferative disease (PTLD) and may be a novel marker of PTLD risk. |
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33. |
CDCA1 may therefore be an ideal tumor-associated antigen useful for the diagnosis and immunotherapy of these cancer |
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34. |
HLA-A, -B and -DRB1 allele frequencies in the Bangladeshi population. |
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35. |
Data demonstrate that the influence of ZNRD1 alleles on disease progression rates are attributable to HLA-A10, help clarify the relationship between the HCP5, HLA-C and HLA-B*57 alleles, and reaffirm a critical role of HLA-B*57 alleles in HIV disease. |
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36. |
Present results suggest that there is a significant relationship between nasal polyposis and HLA-A allele frequency among the Turkish population. |
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37. |
Soluble HLA-A serum level is significantly increased in allergic rhinitis patients with pollen allergy. |
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38. |
The present study suggest that the susceptibility to advanced endometriosis, unlike in the Japanese population, is not associated with HLA-A antigens in the Korean population. |
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39. |
expression of HLA A*2301, A*2402, or A*3201 but not HLA A*2501 protects target cells from lysis by KIR3DL1(+) NK cells |
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40. |
Certain HLA alleles are found in Chinese patients with psoriasis (HLA-A*30, -Cw*06, -DR*07) and psoriatic arthritis (PsA) (HLA-B*27). Psoriasis patients with the HLA-B*27 and/or -Cw*12 may have higher risk of developing PsA. |
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41. |
identified two HLA-A2 restricted T-cell epitopes-TLVTVSSAS and LMISRTPEV--which can yield an expansion of CD8+ T-cells with the ability to kill peptide-loaded target cells and HLA-A2+ IgG+ myeloma cells |
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42. |
HER-2(10(85))-specific human CTL recognized the HER-2/neu+ HLA-A2.1+ tumor cell line SKBR3.A2 |
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43. |
HLA-I serum levels seem to be of prognostic significance in multiple myeloma and might be helpful to identify patients of poor prognosis |
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44. |
The significant increase of HLA-A* 26 in the BD patients without HLA-B*51 suggests that this allele itself might be one of the primary susceptibility genes involved in the development of BD independently of HLA-B*51. |
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45. |
polymorphisms in some alleles of B and C in HLA class I genes are associated with Kawasaki disease in Korean children. |
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46. |
analysis of the ability of most common HLA-B alleles and HLA-A alleles with Bw4 serologic reactivity to protect target cells from lysis by KIR3DL1-dependent NK cells |
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47. |
A population-specific diabetogenic haplotype HLA-A2,Cw1,B56,DR4,DQ8 is associated with high birthweight in Finnish diabetic families. |
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48. |
hla-a haplotypes were associated with higer occurrence of lymphoproliferative disorders after renal transplantation |
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49. |
Co-occurring HLA alleles across loci seem to be more important than individual allelesin squamous cell cervical cancer risk. |
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50. |
Thirty-two novel human leukocyte antigen-A alleles are described. |
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51. |
In this study, samples from 95 SARS patients and 403 healthy controls were typed for HLA-A, -B and -DRB1 alleles and no association was found between HLA variations and SARS. |
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52. |
A novel human leukocyte antigen (HLA) A*24 allele was identified in the Korean population and designated HLA-A*2475 |
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53. |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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54. |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
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55. |
Meta-analysis of gene-disease association and gene-gene interaction. (HuGE Navigator) |
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56. |
Observational study of genotype prevalence and gene-gene interaction. (HuGE Navigator) |
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57. |
Meta-analysis of gene-disease association. (HuGE Navigator) |
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58. |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
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59. |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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60. |
Observational study of genetic testing. (HuGE Navigator) |
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61. |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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62. |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
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63. |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
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64. |
Observational study of gene-environment interaction. (HuGE Navigator) |
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65. |
Observational study of genotype prevalence. (HuGE Navigator) |
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66. |
Observational study of gene-disease association. (HuGE Navigator) |
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67. |
Increased frequency of HLA A2, A11, and B35 alleles in unselected pediatric Henoch Schonlein purpura patient population may be a risk factor for susceptibility. |
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68. |
These findings indicate different immunodominance of Gag169-177 epitope among 3 HLA-A( *)26 subtypes. |
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69. |
analysis of T-cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206 |
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70. |
The researchers investigated the frequency of HLA-A, HLA-B, and HLA-DR allele polymorphisms in Sicily and found evidence of genetic differentiation between the western and eastern sides of Sicily. |
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71. |
pinpoint disease susceptibility to the MHC class I genes HLA-B and HLA-A, in addition to the established associations of the MHC class II genes |
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72. |
Data show that the MAT-1 26-35 and 27-35 peptides adopt strikingly different conformations when bound to HLA-A2. |
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73. |
HLA-A*02 was suntyped in 101 Sinhalese and there was observed a preponderance of the rare allele HLA-A*0211 which was similar to reported frequencies in northern India. |
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74. |
HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma. |
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75. |
HLA-A *0201 restricted ALCAM peptides primed autologous CD8(+) T cells to elicit cytotoxic response against ALCAM(+) human cancer cells. |
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76. |
HFE polymorphism are potentially important predictors of ALT flare-up. |
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77. |
The A1-B8 haplotype hitchhiking with the hemochromatosis C282Y mutation was not associated with a more efficient iron absorption |
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78. |
A T helper effect was demonstrated in HLA-A and HLA-DR1 trangenic mice, and it was particularly strong with epitopes Gag(301-320),Gag(321-340 )and Gag(271-290) |
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79. |
frequency of HLA antigens was significantly increased suggesting that brain cavernoma susceptibility may be associated with HLA antigens |
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80. |
This study analysed the effect of HLA-A on clinical variables in a large Scandinavian sample set, but could not identify any significant contribution from HLA-A on the clinical phenotype in MS. |
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81. |
analysis of novel allele HLA-A*2442 |
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82. |
analysis of novel allele HLA-A*0278 |
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83. |
These results suggest that the HLA-A*3303-B*4403-DRB1*1302 haplotype plays an important role in the development of PHN after herpes zoster, but not in the onset of herpes zoster. |
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84. |
we examine the contribution of the HLA region to the clinical phenotype of UC. |
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85. |
The HLA-A*02 and -A*03 were observed increased frequencies in patients less than 50% hair loss, and HLA-B*27 equally in patients of 50-99% hair loss, alopecia totalis and alopecia universalis. |
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86. |
HLA-A*68020102 has been isolated and sequenced. This variant shows an 11 base pair deletion within the 5' UTR region. The exon sequence is identical to that of A*6802 |
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87. |
In patients with autoimmune thyroiditis the HLA-A24 frequency of was higher than control values while in patients with polyglandular activation of autoimmunity, the HLA-A3 frequency was found to be higher. |
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88. |
Polymorphisms in HIV-1 reverse transcriptase were most evident at sites of least functional or structural constraint and frequently were associated with particular host HLA-A and HLA-B alleles |
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89. |
A new allele, HLA-A* 0261, differs from HLA-A* 020601 by a single-nucleotide substitution at codon 57 (CCG-->GCG) resulting in an amino acid change from Pro to Ala. |
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90. |
A new alleles, HLA-A*6824, differs from A*680102 by a single nucleotide change at position 275 in exon 2, which results in a conservative amino acid substitution from lysine to arginine in the peptide-binding groove at codon 68. |
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91. |
suballeles of the HLA-A2 supertype can effectively present antigenic epitopes in response to preerythrocytic malarial antigens derived from Malian children |
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92. |
The susceptibility to PBC in Chinese individuals is associated with DRB1*0701 allele. |
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93. |
Schizophrenic carriers of the HLA-A10 genotype were clearly most often infected with Chlamydophila, especially C. psittaci. |
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94. |
proof of principle that it is possible to differentially modulate the IFNgamma-induced expression of the HLA-E and HLA-A genes; stimulation of HLA-A expression by IFN-gamma requires nuclear export of HLA-A mRNA by chromosome maintenance region 1 (CRM-1). |
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95. |
HLA-A*02 was significantly higher in the Recovered group than in the Persistent group (P=0.044) of hepatitis B patients. |
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96. |
Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8. HLA-A2, -Cw4, and -Bw46 alleles, or HLA-G1 leads to NK cell apoptosis. |
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97. |
A Gambian TNF haplotype matches the European HLA-A1, B8, DR3 and Chinese HLA-A33, B58, DR3 haplotypes. |
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98. |
A computational method was used to predict the serologic specificity of HLA molecules encoded by HLA-A. |
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99. |
analysis of HLA-A*2451, a new allele found in a Chinese donor |
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100. |
new HLA class I alleles found in Caucasian population: A*3012, B*270505, B*3541 and Cw*0716 |
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101. |
identification of a new variant of the A*2607 allele, named A*260702 |
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102. |
the first high-resolution X-ray structure of HLA-A*1101 in complex with a peptide derived from SARS coronavirus (CoV) nucleocapsid protein is described |
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103. |
anti-HLA class I Abs play an important role in the pathogenesis of obliterative airway disease by inducing growth factor production, apoptosis and chemotaxis of inflammatory cells |
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104. |
HLA-A*3303 restricts an HIV-1 Vpu epitope associated with non-progression. |
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105. |
Familial predisposition to IgA nephropathy is associated with HLA antigens and particular candidate genes. |
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106. |
The frequency of haplotypes HLA-A in systemic lupus erythematosus group was significantly higher than that of control. |
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107. |
The genetic susceptibility of chronic thromboembolic pulmonary hypertension is controlled by HLA polymorphism. |
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108. |
Identification of two new HLA-A variants, HLA-A*2911 and HLA-A*6827 |
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109. |
A novel HLA-A*680104 variant |
|
110. |
Identification of a new allele, HLA-A*3308 |
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111. |
Identification of a novel HLA-A*02 allele, A*0287 |
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112. |
HLA-A*2313 is closest to A*2301 but is likely to stimulate T cells when mismatched |
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113. |
results indicate that the most prominent effect of Nef on HLA-A2 in T cells was to inhibit transport to the cell surface |
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114. |
HLA-A polymorphism is one of the host genetic factors that alter the risk for the development of cervical cancer in Chinese women. |
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115. |
Nef binds directly to the HLA-A2 cytoplasmic tail |
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116. |
Loss of HLA class I gene is associated with pancreatic carcinoma progression |
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117. |
ABCE1 and its peptides could be target molecules in specific immunotherapy for HLA-A2(+) colon cancer patients. |
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118. |
EBV isolates from nasopharyngeal carcinoma of southern China and Taiwan is dominated by an HLA A2-restricted 'epitope-loss variants' of LMP-1 |
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119. |
Identification of 4 novel HLA-A alleles (A*9202, A*680105, A*2630, and A*2915) in an East African population. |
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120. |
HLA-A*9 had no association with the generalized aggressive periodontitis. |
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121. |
HLA-A*0326 differs from A*030101 in a point mutation at codon 268 (AAG-->GAG), generating an amino acid substitution of K to E |
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122. |
the novel allele HLA-A*020112 differs from HLA-A*020101 by a synonymous nucleotide exchange at position 53 in exon 2 (G-->A) |
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123. |
analysis of a new HLA-A*02 allele, (A*0297), identified in a cord blood unit and in her mother |
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124. |
The apparent association of HLA-A*1101 with resistance to HIV-1 infection may reflect, at least in part, an interplay of functional advantages that particular structural features of the peptide-binding groove may confer to HLA-A*1101. |
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125. |
a novel HLA-A0201-restricted cytotoxic T lymphocyte (CTL)-epitope (28-SLYKFSPFPL; FSP06) derived from a mutant O-linked N-acetylglucosamine transferase |
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126. |
HLA alleles A*3001, B*5201, and DRB1*1502 might increase the susceptibility to Takayasu arteritis, while A*2602 might protect against it. |
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127. |
The genetic distance (GD) estimated according to HLA-A, -B, and -C allele frequency indicates that Mongolian and Hui have the closest relationship. |
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128. |
selective down-regulation of HLA-A and HLA-Bw6 allospecificities associated with HLA-Bw4 preservation in leukemic cells |
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129. |
The allelic product of HLA-B*3531 is composed of B35 in its alpha1 domain and of B61(40) in its alpha2 domain. Both specificities are only weakly detectable with available sera. |
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130. |
The new allele HLA-B*4431 only displayed B44 seroreactivity, which demonstrates that epitopes crucial for B60(40) specificity must be located in the alpha1 domain. |
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131. |
HLA-A*6818 N displays a sequence identical to that of the HLA-A*6802 allele. This duplication creates a shift of the reading frame, which leads to a premature non-sense codon at position 59 of the null allele. |
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132. |
The nucleotide sequences of HLA-A*1112 exons 2 and 3 are identical to HLA-A*11011 except for a single nucleotide substitution in codon 90 (GAC-->GCC). |
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133. |
HLA-A2 mutants with substitutions at known TCR contact sites were compared for recognition by hapten-cross-reactive CTL. Similar AA contacts are made by the TCR during recognition of immunizing or cross-reacting complexes. |
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134. |
Novel conditions are required for priming and antigen-specific expansion of cytotoxic T cells reactive to the HIV-1 p17 Gag(77-85) epitope on circulating naive CD8+ precursor cells derived from HLA-A*0201 HIV-seronegative healthy donors. |
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135. |
magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype |
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136. |
The HLA class I A locus affects susceptibility to type 1 diabetes. |
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137. |
HLA-A*2402 together with microsatellite D6S248-15 allele could be B27-independent markers of additional susceptibility gene/s localised in the region telomeric to HLA-A in Basque ankylosing spondylitis patients. |
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138. |
the T cell epitope HCV core 35-44 stabilizes HLA-A2 and HLA-E and inhibits cytolysis mediated by natural killer cells |
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139. |
Identification of HLA-A2-restricted, naturally processed epitopes derived from proinsulin, an autoantigen likely to play an important role in the pathogenesis of type 1 diabetes. |
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140. |
Coordinated downregulation of the antigen presentation machinery and HLA class I/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer |
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141. |
Results indicate that mutations at both position 65 and position 66 influence peptide binding by the human class I major histocompatibility complex molecule HLA-A2 to various extents. |
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142. |
Transgenic expression in NOD mice of HLA-A*0201, in the absence of murine class I MHC molecules, is sufficient to mediate autoreactive CD8+ T cell responses contributing to development of type 1 diabetes |
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143. |
The HLA-A*1115-bearing haplotype was B*350101; Cw*040101; DRB1*140101; DRB3*020201; DQA1*010401; DQB1*0503; DPA1*0103/07; DPB1*030101. Extensive serological typing indicated that this allele essentially encodes a 'normal' HLA-A11 specificity. |
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144. |
Gene frequencies and haplotypic associations within HLA-A loci were determined at a high-resolution allelic level and should provide useful information in anthropology, bone marrow donor registry, legal medicine, and disease association studies. |
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145. |
identified 21 critical polymorphic functional residue positions (CPFRP) that significantly reduced functional pocket variability to just 189 among 212 HLA-A alleles |
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146. |
Disparate binding of chaperone proteins by HLA-A subtypes |
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147. |
transport of HLA-A2 to cell surface disrupted by Nef |
|
148. |
HLA class I antigen loss was significantly correlated with glioblastoma multiforme |
|
149. |
A novel HLA-A allele, HLA-A*0279, was identified. |
|
150. |
first example of the generation of CTLs in the absence of proliferation of T4 cells (mixed lymphocyte culture) and the description of an aberrant allele, A*0118N, that may behave as a minor histocompatibility Ag, with implications in allorecognition |
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151. |
HLA-A*9203, found in Taiwan using sequence-based typing method, was identical to HLA-A*0207 in exon 3 but differed in exon 2 by five nucleotide substitutions at positions 240-282 corresponding to three amino acid changes at codons 62, 66 and 70. |
|
152. |
HLA-A allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais. |
|
153. |
Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer. |
|
154. |
Additional risk of hereditary hemochromatosis given by class I HLA antigens may be secondary to the HFE gene linkage disequilibrium with certain class I alleles or to the existence of other neighboring genetic pathogenetic factors in our Spanish sample. |
|
155. |
HLA-A *0101 is mutated in a colorectal tumor cell line |
|
156. |
HLA-A, -B, and -DRB1 alleles in a total of 236 Taiwanese adults with Graves' disease and 533 racially matched normal control subjects were examined |
|
157. |
Proposed association of A24 and A26 with schizophrenia in Japan was not confirmed. |
|
158. |
The association and linkage of the class I HLA-A2 allele with autism suggests its involvement in the etiology of autism. |
|
159. |
A high-resolution structure of the human MHC-I molecule HLA-A*1101 is presented in which it forms a complex with a sequence homologue of a peptide that occurs naturally in hepatitis B virus DNA polymerase. |
|
160. |
a soluble recombinant HLA-A*1101 molecule has been expressed and used to assemble a complex with beta2-microglobulin and a Nef decapeptide. |
|
161. |
HLA alleles plays an important role in the development of central nervous system meningiomas. |
|
162. |
Significant increase in frequency of HLA-A were observed in leprosy patients when compared with controls. |
|
163. |
two new HLA-A alleles, A*2419 and A* 3011, that were initially recognized by an aberrant serological pattern. |
|
164. |
Eight new HLA-A alleles associated with antigens in the A2 CREG. |
|
165. |
This study shows that HLA-A*2402 is a ligand for KIR3DL1 and demonstrates how the binding of KIR3DL1 to Bw4(+) ligands depends upon the bound peptide as well as HLA and KIR3DL1 polymorphism. |
|
166. |
In hepatocellular carcinoma patients, HLA-A could induce cytotoxic T lymphocytes for glypican 3-based immunotherapy (HLA-A2 AND HLA-A24) |
|
167. |
Intrathecal production and fluctuations in CSF and serum concentrations of sHLA-I were reciprocal in multiple sclerosis. |
|
168. |
A fluorescence polarization competitive peptide-binding assay was tested on a panel of 15 well-defined HLA-A0201 ligands from various sources covering a broad range of binding affinities. |
|
169. |
HTLV-1 Tax protein epitopes were tested for protective efficacy in a preclinical model of infection using HTLV-1 Tax recombinant vaccinia virus and HLA-A*0201 transgenic mice. |