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    snb-1 Synaptobrevin-1 [ Caenorhabditis elegans ]

    Gene ID: 266648, updated on 23-Nov-2023

    Summary

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    Gene symbol
    snb-1
    Gene description
    Synaptobrevin-1
    Primary source
    WormBase:WBGene00004897
    Locus tag
    CELE_T10H9.4
    See related
    AllianceGenome:WB:WBGene00004897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in several processes, including chemical synaptic transmission; defecation; and regulation of hindgut contraction. Located in several cellular components, including axon; presynaptic active zone; and secretory vesicle. Is expressed in several structures, including epithelial cell; excretory gland cell; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to several human genes including VAMP2 (vesicle associated membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (6655562..6656501, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene t-SNARE coiled-coil homology domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants. Nonet ML, et al. J Neurosci, 1998 Jan 1. PMID 9412487, Free PMC Article
    2. Spontaneous Vesicle Fusion Is Differentially Regulated at Cholinergic and GABAergic Synapses. Liu H, et al. Cell Rep, 2018 Feb 27. PMID 29490270
    3. Critical and sensitive periods for reversing the effects of mechanosensory deprivation on behavior, nervous system, and development in Caenorhabditis elegans. Rai S, et al. Dev Neurobiol, 2007 Sep 15. PMID 17497697
    4. A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Sandoval GM, et al. Nat Neurosci, 2006 May. PMID 16604067
    5. Characterization of TAG-63 and its role on axonal transport in C. elegans. Bhan P, et al. Traffic, 2020 Feb. PMID 31622527

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of hindgut contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, cholinergic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Synaptobrevin-1
    NP_001379956.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6655562..6656501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392536.1 → NP_001379956.1  Synaptobrevin-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02495
      Conserved Domains (1) summary
      cd15870
      Location:22 → 84
      R-SNARE_VAMP2; SNARE motif of VAMP2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02495.1

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