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    APC11 anaphase promoting complex subunit 11 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851554, updated on 7-Jan-2024

    Summary

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    Gene symbol
    APC11
    Gene description
    anaphase promoting complex subunit 11
    Primary source
    SGD:S000002166
    Locus tag
    YDL008W
    See related
    AllianceGenome:SGD:S000002166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process and protein ubiquitination. Part of anaphase-promoting complex. Orthologous to human ANAPC11 (anaphase promoting complex subunit 11). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (433497..433994)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene glutathione-disulfide reductase GRX6 Neighboring gene uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of the anaphase promoting complex/cyclosome by the degradation of its unassembled catalytic subunit, Apc11. Volpe M, et al. FASEB J, 2019 Sep. PMID 31162950
    2. Quantitative framework for ordered degradation of APC/C substrates. Lu D, et al. BMC Biol, 2015 Nov 16. PMID 26573515, Free PMC Article
    3. Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate. Matsusaka T, et al. Biol Open, 2014 Sep 12. PMID 25217616, Free PMC Article
    4. An in vitro assay for Cdc20-dependent mitotic anaphase-promoting complex activity from budding yeast. Schuyler SC, et al. Methods Mol Biol, 2009. PMID 19475395
    5. Meiosis-specific destruction of the Ume6p repressor by the Cdc20-directed APC/C. Mallory MJ, et al. Mol Cell, 2007 Sep 21. PMID 17889668, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    anaphase promoting complex subunit 11
    NP_010276.3
    • Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      433497..433994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180067.3 → NP_010276.3  TPA: anaphase promoting complex subunit 11 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010276.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRX9, Q12157
      UniProtKB/TrEMBL
      A0A8H8UMR3, A6ZXV7, B3LGR7, C7GW68, C8Z4R1, G2WCE5, N1P7W6
      Conserved Domains (1) summary
      pfam12861
      Location:1 → 102
      zf-ANAPC11; Anaphase-promoting complex subunit 11 RING-H2 finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12157.1

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