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    CQD2 Cqd2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850955, updated on 11-Apr-2024

    Summary

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    Gene symbol
    CQD2
    Gene description
    Cqd2p
    Primary source
    SGD:S000004243
    Locus tag
    YLR253W
    See related
    AllianceGenome:SGD:S000004243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MCP2; MRX13
    Summary
    Involved in lipid homeostasis and mitochondrion organization. Located in mitochondrial inner membrane. Is integral component of mitochondrial membrane. Orthologous to human ADCK1 (aarF domain containing kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (642627..644336)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ssp120p Neighboring gene ethanol metabolism protein Neighboring gene Ndl1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae. Kemmerer ZA, et al. Nat Commun, 2021 Aug 6. PMID 34362905, Free PMC Article
    2. Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Tu BP, et al. Science, 2005 Nov 18. PMID 16254148
    3. Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis. Tan T, et al. J Cell Sci, 2013 Aug 15. PMID 23781023
    4. The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria. Khosravi S, et al. J Cell Sci, 2023 May 15. PMID 37073556, Free PMC Article
    5. Contribution of ERMES subunits to mature peroxisome abundance. Esposito M, et al. PLoS One, 2019. PMID 30908556, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cqd2p
    NP_013354.1
    • Mitochondrial protein involved in lipid homeostasis; involved in mobilization of CoQ from its site of synthesis on the inner mitochondrial membrane to other sites of action; associates with mitochondrial ribosome; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of ERMES complex; transcription is periodic during metabolic cycle; homologous to human aarF domain containing kinase, ADCK1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      642627..644336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182140.1 → NP_013354.1  TPA: Cqd2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013354.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYQ0, Q06567
      UniProtKB/TrEMBL
      A0A8H4BZQ1, A7A1D5, B3RHD7, B5VNG7, C7GQY4, C8ZDL6, G2WJ78, N1P1F2
      Conserved Domains (1) summary
      COG0661
      Location:47 → 569
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06567.1

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