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    VAD1 GRAM domain family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839232, updated on 15-Oct-2023

    Summary

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    Gene symbol
    VAD1
    Gene description
    GRAM domain family protein
    Primary source
    Araport:AT1G02120
    Locus tag
    AT1G02120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T7I23.28; T7I23_28; VASCULAR ASSOCIATED DEATH1
    Summary
    Encodes VAD1 (Vascular Associated Death1), a regulator of cell death and defense responses in vascular tissues. VAD1 is a putative membrane associated protein and contains a GRAM domain. vad1 is a lesion mimic mutant that exhibits light conditional appearance of propagative HR (hypersensitive response)-like lesions along the vascular system.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    17
    Sequence:
    Chromosome: 1; NC_003070.9 (395689..400001)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Leucine carboxyl methyltransferase Neighboring gene bZIP domain class transcription factor (DUF630 and DUF632) Neighboring gene RAS 5 Neighboring gene ncRNA Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An essential role for the VASt domain of the Arabidopsis VAD1 protein in the regulation of defense and cell death in response to pathogens. Khafif M, et al. PLoS One, 2017. PMID 28683084, Free PMC Article
    2. Ethylene is one of the key elements for cell death and defense response control in the Arabidopsis lesion mimic mutant vad1. Bouchez O, et al. Plant Physiol, 2007 Oct. PMID 17720753, Free PMC Article
    3. Vascular associated death1, a novel GRAM domain-containing protein, is a regulator of cell death and defense responses in vascular tissues. Lorrain S, et al. Plant Cell, 2004 Aug. PMID 15269331, Free PMC Article
    4. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VAD1 acts as a negative regulator of cell death associated with the plant immune response and the VASt domain of this unknown protein plays an essential role in this function.
      Title: An essential role for the VASt domain of the Arabidopsis VAD1 protein in the regulation of defense and cell death in response to pathogens.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001331326.1
    NM_100092.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ethylene IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salicylic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    GRAM domain family protein
    NP_171714.2
    • VASCULAR ASSOCIATED DEATH1 (VAD1); INVOLVED IN: defense response to bacterium, negative regulation of programmed cell death; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: GRAM (InterPro:IPR004182); BEST Arabidopsis thaliana protein match is: C2 domain-containing protein / GRAM domain-containing protein (TAIR:AT3G59660.1); Has 1155 Blast hits to 1034 proteins in 185 species: Archae - 0; Bacteria - 0; Metazoa - 619; Fungi - 222; Plants - 157; Viruses - 0; Other Eukaryotes - 157 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      395689..400001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331325.1 → NP_001321166.1  GRAM domain family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQ22

    2. NM_100092.3 → NP_171714.2  GRAM domain family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171714.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HVW5
      UniProtKB/TrEMBL
      A0A178W223, A0A5S9S6A4, A0A654E7B3
      Conserved Domains (2) summary
      cd13220
      Location:80 → 173
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:275 → 424
      DUF4782; Domain of unknown function (DUF4782)

    3. NM_001331326.1 → NP_001321165.1  GRAM domain family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQ01, Q8VZF8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HVW5.1

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