U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    AT5G26680 5'-3' exonuclease family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832721, updated on 7-Sep-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    AT5G26680
    Gene description
    5'-3' exonuclease family protein
    Primary source
    Araport:AT5G26680
    Locus tag
    AT5G26680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See AT5G26680 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Sequence:
    Chromosome: 5; NC_003076.8 (9311446..9315550, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ubiquitin carboxyl-terminal hydrolase-like protein Neighboring gene Glutamyl/glutaminyl-tRNA synthetase, class Ic Neighboring gene RmlC-like cupins superfamily protein Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene Pectinacetylesterase family protein Neighboring gene myb domain protein 86

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Requirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis. Zhang J, et al. Plant J, 2016 Sep. PMID 27231839, Free PMC Article
    2. Shade avoidance 6 encodes an Arabidopsis flap endonuclease required for maintenance of genome integrity and development. Zhang Y, et al. Nucleic Acids Res, 2016 Feb 18. PMID 26721386, Free PMC Article
    3. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At5g26680 role in mediating transcriptional gene silencing as well as maintaining genome stability
      Title: Requirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis.
    2. Data show that shade avoidance 6 (SAV6; At5g26680), encodes flap endonuclease-1 (FEN1), assures proper root development through maintenance of genome integrity.
      Title: Shade avoidance 6 encodes an Arabidopsis flap endonuclease required for maintenance of genome integrity and development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001161268.2
    NM_001343976.1
    NM_001343977.1
    NM_001343978.1
    NM_180546.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flap endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to UV IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    5'-3' exonuclease family protein
    NP_001154740.1
    • 5'-3' exonuclease family protein; FUNCTIONS IN: 5'-3' exonuclease activity, DNA binding, catalytic activity, nuclease activity; INVOLVED IN: DNA repair; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: XPG conserved site (InterPro:IPR019974), XPG N-terminal (InterPro:IPR006085), DNA repair protein (XPGC)/yeast Rad (InterPro:IPR006084), 5'-3' exonuclease, N-terminal (InterPro:IPR002421), 5'-3' exonuclease, C-terminal subdomain (InterPro:IPR020045), Helix-hairpin-helix motif, class 2 (InterPro:IPR008918), XPG/RAD2 endonuclease (InterPro:IPR006086); BEST Arabidopsis thaliana protein match is: 5'-3' exonuclease family protein (TAIR:AT1G29630.2); Has 3563 Blast hits to 3243 proteins in 839 species: Archae - 284; Bacteria - 855; Metazoa - 643; Fungi - 727; Plants - 266; Viruses - 42; Other Eukaryotes - 746 (source: NCBI BLink).
    NP_850877.2
    • 5'-3' exonuclease family protein; FUNCTIONS IN: 5'-3' exonuclease activity, DNA binding, catalytic activity, nuclease activity; INVOLVED IN: DNA repair; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: XPG conserved site (InterPro:IPR019974), XPG N-terminal (InterPro:IPR006085), DNA repair protein (XPGC)/yeast Rad (InterPro:IPR006084), 5'-3' exonuclease, C-terminal subdomain (InterPro:IPR020045), 5'-3' exonuclease, N-terminal (InterPro:IPR002421), Helix-hairpin-helix motif, class 2 (InterPro:IPR008918), XPG/RAD2 endonuclease (InterPro:IPR006086); BEST Arabidopsis thaliana protein match is: 5'-3' exonuclease family protein (TAIR:AT1G29630.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9311446..9315550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161268.2 → NP_001154740.1  5'-3' exonuclease family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154740.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65251
      UniProtKB/TrEMBL
      A0A7G2FGQ6
      Conserved Domains (1) summary
      PTZ00217
      Location:1 → 383
      PTZ00217; flap endonuclease-1; Provisional

    2. NM_001343978.1 → NP_001332058.1  5'-3' exonuclease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UK25, A0A1P8BFQ5, A0A384KCK0, A0A7G2FA98
      Conserved Domains (1) summary
      PTZ00217
      Location:1 → 362
      PTZ00217; flap endonuclease-1; Provisional

    3. NM_001343977.1 → NP_001332057.1  5'-3' exonuclease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UK25, A0A1P8BFQ5, A0A384KCK0, A0A7G2FA98
      Conserved Domains (1) summary
      PTZ00217
      Location:1 → 362
      PTZ00217; flap endonuclease-1; Provisional

    4. NM_001343976.1 → NP_001332056.1  5'-3' exonuclease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UK25, A0A1P8BFQ5, A0A384KCK0, A0A7G2FA98
      Conserved Domains (1) summary
      PTZ00217
      Location:1 → 362
      PTZ00217; flap endonuclease-1; Provisional

    5. NM_180546.3 → NP_850877.2  5'-3' exonuclease family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850877.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FGQ6, F4K191
      Conserved Domains (3) summary
      cd09907
      Location:222 → 290
      H3TH_FEN1-Euk; H3TH domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease: Eukaryotic homologs
      cd09867
      Location:4 → 346
      PIN_FEN1; PIN domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      PTZ00217
      Location:1 → 359
      PTZ00217; flap endonuclease-1; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65251.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools