adra1aa adrenoceptor alpha 1Aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adra1aaprovided by ZNC
Official Full Name: adrenoceptor alpha 1Aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2831
See related: Ensembl:ENSDARG00000028725 AllianceGenome:ZFIN:ZDB-GENE-030131-2831
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: adra1a; fc18h12; wu:fc18h12
Summary: Predicted to enable adrenergic receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (5024468..5080889)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (4968201..5024622)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha2-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adrenoceptor alpha 1Aa

Names: adrenergic, alpha-1A-, receptor; adrenergic, alpha-1Aa, receptor; adrenoceptor alpha 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001324454.1 → NP_001311383.1 adrenoceptor alpha 1Aa

Status: VALIDATED

Source sequence(s)

CABZ01078152, CABZ01078154, CABZ01078156

UniProtKB/TrEMBL

A0A8M1P8T8, E7FG90

Related

ENSDARP00000035603.8, ENSDART00000030938.9

Conserved Domains (3) summary

pfam00001
Location:57 → 339

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl00630
Location:270 → 320

YdcF-like; YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been ...

cl21561
Location:52 → 173

7tm_4; Olfactory receptor