fut8a fucosyltransferase 8a (alpha (1,6) fucosyltransferase) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fut8aprovided by ZNC
Official Full Name: fucosyltransferase 8a (alpha (1,6) fucosyltransferase)provided by ZNC
Primary source: ZFIN:ZDB-GENE-031118-20
See related: Ensembl:ENSDARG00000015449 AllianceGenome:ZFIN:ZDB-GENE-031118-20
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fut8; wu:fd47h04
Summary: Enables alpha-(1->6)-fucosyltransferase activity. Acts upstream of or within N-glycan fucosylation. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Orthologous to human FUT8 (fucosyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (33719339..33906488)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (33766828..33953975)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables alpha-(1->6)-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-(1->6)-fucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycoprotein 6-alpha-L-fucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-glycan fucosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within N-glycan fucosylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fucosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sarcomerogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-(1,6)-fucosyltransferase

Names: alpha-6-fucosyltransferase; fucosyltransferase 8 (alpha (1,6) fucosyltransferase)

XP_005158803.1

EC 2.4.1.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361235.1 → NP_001348164.1 alpha-(1,6)-fucosyltransferase

Status: VALIDATED

Source sequence(s)

BX936404, BX950853

UniProtKB/TrEMBL

A0A8M2B5M6, F1QW63

Conserved Domains (3) summary

cd11300
Location:175 → 500

Fut8_like; Alpha 1-6-fucosyltransferase

cd11792
Location:507 → 561

SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)

cl25732
Location:37 → 142

SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

33719339..33906488

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158746.4 → XP_005158803.1 alpha-(1,6)-fucosyltransferase

UniProtKB/TrEMBL

F1QW63

Related

ENSDARP00000122544.1, ENSDART00000132294.2

Conserved Domains (3) summary

cd11300
Location:175 → 500

Fut8_like; Alpha 1-6-fucosyltransferase

cd11792
Location:507 → 561

SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)

cl25732
Location:37 → 142

SMC_N; RecF/RecN/SMC N terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001003855.1: Suppressed sequence

Description

NM_001003855.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.