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    PIEZO1 piezo type mechanosensitive ion channel component 1 [ Bos taurus (cattle) ]

    Gene ID: 789183, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PIEZO1provided by VGNC
    Official Full Name
    piezo type mechanosensitive ion channel component 1provided by VGNC
    Primary source
    VGNC:VGNC:32864
    See related
    BGD:BT10183; Ensembl:ENSBTAG00000020944
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PIEZO1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (13939776..13995882, complement)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene snail family transcriptional repressor 3 Neighboring gene ring finger protein 166 Neighboring gene cytosolic thiouridylase subunit 2 Neighboring gene microRNA mir-2327 Neighboring gene chromatin licensing and DNA replication factor 1 Neighboring gene adenine phosphoribosyltransferase Neighboring gene galactosamine (N-acetyl)-6-sulfatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. Wang S, et al. J Clin Invest, 2016 Dec 1. PMID 27797339, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data demonstrate that PIEZO1 is required for the regulation of NO formation, vascular tone, and blood pressure.
      Title: Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in detection of mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    piezo-type mechanosensitive ion channel component 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      13939776..13995882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059877396.1 → XP_059733379.1  piezo-type mechanosensitive ion channel component 1 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MH18
      Related
      ENSBTAP00000069924.1, ENSBTAT00000087298.2

    2. XM_059877395.1 → XP_059733378.1  piezo-type mechanosensitive ion channel component 1 isoform X2

    3. XM_059877397.1 → XP_059733380.1  piezo-type mechanosensitive ion channel component 1 isoform X4

    4. XM_015475784.3 → XP_015331270.2  piezo-type mechanosensitive ion channel component 1 isoform X1

      UniProtKB/TrEMBL
      F1MD64
      Related
      ENSBTAP00000027897.7, ENSBTAT00000027897.7
      Conserved Domains (2) summary
      pfam12166
      Location:2102 → 2510
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1237 → 1458
      PIEZO; Piezo

    5. XM_059877398.1 → XP_059733381.1  piezo-type mechanosensitive ion channel component 1 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials
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