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    Man2c1 mannosidase, alpha, class 2C, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 73744, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Man2c1provided by MGI
    Official Full Name
    mannosidase, alpha, class 2C, member 1provided by MGI
    Primary source
    MGI:MGI:1920994
    See related
    Ensembl:ENSMUSG00000032295 AllianceGenome:MGI:1920994
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110025H24Rik
    Summary
    Predicted to enable alpha-mannosidase activity. Predicted to be involved in oligosaccharide catabolic process. Predicted to be located in nucleoplasm. Orthologous to human MAN2C1 (mannosidase alpha class 2C member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 30.4), ovary adult (RPKM 29.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 B; 9 30.89 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57037953..57049497)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57130675..57142213)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 9 Neighboring gene predicted gene 10658 Neighboring gene STARR-positive B cell enhancer ABC_E5069 Neighboring gene STARR-seq mESC enhancer starr_24217 Neighboring gene RIKEN cDNA 2700012I20 gene Neighboring gene STARR-positive B cell enhancer ABC_E9329 Neighboring gene STARR-positive B cell enhancer ABC_E711 Neighboring gene transcriptional regulator, SIN3A (yeast) Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56978348-56978531 Neighboring gene STARR-positive B cell enhancer ABC_E3832 Neighboring gene mannosidase, alpha, class 2C, member 1, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56995851-56996034 Neighboring gene STARR-positive B cell enhancer ABC_E5070 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57006119-57006228 Neighboring gene nei endonuclease VIII-like 1 (E. coli) Neighboring gene COMM domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Accumulation of free oligosaccharides and tissue damage in cytosolic α-mannosidase (Man2c1)-deficient mice. Paciotti S, et al. J Biol Chem, 2014 Apr 4. PMID 24550399, Free PMC Article
    2. Cloning and expression of mouse cytosolic alpha-mannosidase (Man2c1). Costanzi E, et al. Biochim Biophys Acta, 2006 Oct. PMID 16904268
    3. A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot. McDaniel AH, et al. Mamm Genome, 2006 Nov. PMID 17103052, Free PMC Article
    4. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
    5. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-mannosidase 2C1
    Names
    alpha-D-mannoside mannohydrolase
    cytosolic alpha-D-mannosidase
    neutral/cytosolic alpha-mannosidase
    NP_082912.1
    XP_006511557.1
    XP_006511562.1
    XP_017169108.1
    XP_030100511.1
    XP_030100512.1
    XP_030100514.1
    XP_030100515.1
    XP_030100517.1
    XP_036011231.1
    XP_036011232.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028636.2 → NP_082912.1  alpha-mannosidase 2C1

      See identical proteins and their annotated locations for NP_082912.1

      Status: PROVISIONAL

      Source sequence(s)
      AC132406
      Consensus CDS
      CCDS40646.1
      UniProtKB/Swiss-Prot
      Q3ZCX9, Q91W89
      UniProtKB/TrEMBL
      Q8BWY6
      Related
      ENSMUSP00000125478.2, ENSMUST00000160147.8
      Conserved Domains (4) summary
      cd10813
      Location:251 → 502
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:517 → 595
      Alpha-mann_mid; Alpha mannosidase, middle domain
      COG0383
      Location:39 → 1034
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
      pfam07748
      Location:621 → 1030
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57037953..57049497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313619.3 → XP_017169108.1  alpha-mannosidase 2C1 isoform X2

      UniProtKB/TrEMBL
      A0A1S6GWG9
      Conserved Domains (2) summary
      cd10813
      Location:277 → 569
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:65 → 1066
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    2. XM_006511494.5 → XP_006511557.1  alpha-mannosidase 2C1 isoform X1

      UniProtKB/TrEMBL
      A0A1S6GWG9
      Conserved Domains (2) summary
      cd10813
      Location:277 → 569
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:65 → 1101
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    3. XM_006511499.5 → XP_006511562.1  alpha-mannosidase 2C1 isoform X10

      UniProtKB/TrEMBL
      A0A1S6GWG9
      Conserved Domains (2) summary
      cd10813
      Location:277 → 528
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:65 → 1071
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    4. XM_030244651.2 → XP_030100511.1  alpha-mannosidase 2C1 isoform X3

      UniProtKB/TrEMBL
      A0A1S6GWG9
      Conserved Domains (2) summary
      cd10813
      Location:277 → 528
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:65 → 1025
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    5. XM_030244655.1 → XP_030100515.1  alpha-mannosidase 2C1 isoform X8

      UniProtKB/TrEMBL
      Q8BWY6
      Conserved Domains (2) summary
      cd10813
      Location:92 → 343
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:93 → 875
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    6. XM_030244652.2 → XP_030100512.1  alpha-mannosidase 2C1 isoform X4

      UniProtKB/TrEMBL
      Q8BWY6
      Conserved Domains (2) summary
      cd10813
      Location:146 → 438
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:147 → 970
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    7. XM_030244657.2 → XP_030100517.1  alpha-mannosidase 2C1 isoform X9

      Conserved Domains (2) summary
      COG0383
      Location:21 → 792
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
      cl15692
      Location:21 → 260
      CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

    8. XM_036155338.1 → XP_036011231.1  alpha-mannosidase 2C1 isoform X5

      UniProtKB/TrEMBL
      Q8BWY6
      Conserved Domains (2) summary
      cd10813
      Location:146 → 397
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:147 → 929
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    9. XM_036155339.1 → XP_036011232.1  alpha-mannosidase 2C1 isoform X7

      UniProtKB/TrEMBL
      Q8BWY6
      Conserved Domains (2) summary
      cd10813
      Location:146 → 397
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:147 → 894
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    10. XM_030244654.2 → XP_030100514.1  alpha-mannosidase 2C1 isoform X6

      UniProtKB/TrEMBL
      Q8BWY6
      Conserved Domains (2) summary
      cd10813
      Location:92 → 384
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:93 → 916
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    RNA

    1. XR_003948025.2 RNA Sequence

    2. XR_004935579.1 RNA Sequence

    3. XR_001779028.3 RNA Sequence

    4. XR_004935580.1 RNA Sequence

    5. XR_001779038.3 RNA Sequence

    6. XR_003948034.2 RNA Sequence

    7. XR_004935581.1 RNA Sequence

    8. XR_001779027.3 RNA Sequence

    9. XR_004935582.1 RNA Sequence

    10. XR_003948031.2 RNA Sequence

    11. XR_003948030.2 RNA Sequence

    12. XR_001779034.2 RNA Sequence

    13. XR_001779033.2 RNA Sequence

    14. XR_001779035.2 RNA Sequence

      Related
      ENSMUST00000161663.8

    15. XR_001779040.2 RNA Sequence

    16. XR_003948032.2 RNA Sequence

    17. XR_003948033.2 RNA Sequence

    18. XR_004935583.1 RNA Sequence

    19. XR_001779037.2 RNA Sequence

    20. XR_001779039.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W89.1 GenPept UniProtKB/Swiss-Prot:Q91W89

    Gene LinkOut

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