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    CCR5 C-C motif chemokine receptor 5 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 735311, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CCR5provided by VGNC
    Official Full Name
    C-C motif chemokine receptor 5provided by VGNC
    Primary source
    VGNC:VGNC:84217
    Locus tag
    EGK_11711
    See related
    Ensembl:ENSMMUG00000055383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (102388544..102394326)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (96169130..96175005, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 3 Neighboring gene uncharacterized LOC106996934 Neighboring gene C-C motif chemokine receptor 2 Neighboring gene C-C motif chemokine receptor like 2 Neighboring gene lactotransferrin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV. Kelly KM, et al. J Am Heart Assoc, 2014 Apr 2. PMID 24695652, Free PMC Article
    2. A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251. Van Rompay KK, et al. J Virol, 2014 Feb. PMID 24307581, Free PMC Article
    3. TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection. Minang JT, et al. Virology, 2011 Jan 5. PMID 21035160, Free PMC Article
    4. Peripheral blood CD4 and CD8 double-positive T cells of rhesus macaques become vulnerable to Simian Immunodeficiency Virus by in vitro stimulation due to the induction of CCR5. Matsumoto Y, et al. J Vet Med Sci, 2010 Aug. PMID 20224239
    5. Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys. Veazey RS, et al. J Virol, 2008 Jun. PMID 18367534, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of CCR5 on brain perivascular macrophages in simian immunodeficiency virus-infected rhesus macaques.
      Title: Downregulation of CCR5 on brain perivascular macrophages in simian immunodeficiency virus-infected rhesus macaques.
    2. Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission.
      Title: Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission.
    3. Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5.
      Title: Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5.
    4. CCR5 inhibition may provide a cardioprotective benefit in SIV infection by preventing cardiomyocyte CCR5 signaling.
      Title: CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.
    5. A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
      Title: A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
    6. CCR5 downregulation on CD4(+) T cells by TCR activation has no measurable effect on susceptibility to SAIDS.
      Title: TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection.
    7. CD4 and CD8 T cells are more vulnerable to SIV infection, indicating the the ability to express CCR5 may activate and hassten T cell death by SIV infection in vitro.
      Title: Peripheral blood CD4 and CD8 double-positive T cells of rhesus macaques become vulnerable to Simian Immunodeficiency Virus by in vitro stimulation due to the induction of CCR5.
    8. observed a significantly higher loss of CCR5(+) CD45RA(-) CD4(+) T cells in CD8(+) lymphocyte-depleted macaques than in controls
      Title: Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys.
    9. Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
      Title: Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virus.
    10. Results estimate the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut.
      Title: Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables C-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables chemokine (C-C motif) ligand 5 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-C chemokine receptor type 5
    Names
    C-C CKR-5
    C-C chemokine receptor 5
    CC chemokine receptor 5
    CC-CKR-5
    CCR-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042773.3 → NP_001036238.2  C-C chemokine receptor type 5

      See identical proteins and their annotated locations for NP_001036238.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      DQ499963, DQ902537
      UniProtKB/Swiss-Prot
      P61813
      UniProtKB/TrEMBL
      A0A8J8XUT3, G7MIT8, Q09GT7, Q09GU2, Q09GV8, Q09GX6, Q09GY8
      Conserved Domains (1) summary
      PHA03087
      Location:2 → 304
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

    2. NM_001309402.1 → NP_001296331.1  C-C chemokine receptor type 5

      See identical proteins and their annotated locations for NP_001296331.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      DQ499963, JU480013
      UniProtKB/Swiss-Prot
      P61813
      UniProtKB/TrEMBL
      A0A8J8XUT3, G7MIT8, Q09GT7, Q09GU2, Q09GV8, Q09GX6, Q09GY8
      Conserved Domains (1) summary
      PHA03087
      Location:2 → 304
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      102388544..102394326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015131082.2 → XP_014986568.1  C-C chemokine receptor type 5 isoform X1

      UniProtKB/TrEMBL
      A0A5F8AE97, Q09GU2, Q09GV8, Q09GX6, Q09GY8
      Related
      ENSMMUP00000075259.1, ENSMMUT00000092926.1
      Conserved Domains (1) summary
      PHA03087
      Location:29 → 331
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61813.1 GenPept UniProtKB/Swiss-Prot:P61813

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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