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    Zfp618 zinc finger protein 618 [ Mus musculus (house mouse) ]

    Gene ID: 72701, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp618provided by MGI
    Official Full Name
    zinc finger protein 618provided by MGI
    Primary source
    MGI:MGI:1919950
    See related
    Ensembl:ENSMUSG00000028358 AllianceGenome:MGI:1919950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nedd10; Znf618; bM257P7.1; 2810031P15Rik; 2810040O04Rik; D430033D05Rik
    Summary
    Predicted to enable identical protein binding activity and transcription coregulator binding activity. Predicted to be involved in positive regulation of chromatin binding activity. Predicted to be located in pericentric heterochromatin. Orthologous to human ZNF618 (zinc finger protein 618). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 11.3), CNS E11.5 (RPKM 10.0) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 B3; 4 33.82 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62883792..63057946)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62965555..63139709)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24117 Neighboring gene STARR-seq mESC enhancer starr_10433 Neighboring gene predicted gene, 25391 Neighboring gene predicted gene, 30764 Neighboring gene alpha 1 microglobulin/bikunin precursor Neighboring gene kinesin family member 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 618
    Names
    neural precursor cell expressed, developmentally down-regulated gene 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369113.1 → NP_001356042.1  zinc finger protein 618 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL691431, AL691496
      Conserved Domains (1) summary
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001369114.1 → NP_001356043.1  zinc finger protein 618 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL691431, AL691496
      Conserved Domains (1) summary
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001369115.1 → NP_001356044.1  zinc finger protein 618 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL691431, AL691496
      Conserved Domains (1) summary
      sd00017
      Location:92 → 112
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001369116.1 → NP_001356045.1  zinc finger protein 618 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL691431, AL691496
      Conserved Domains (1) summary
      sd00017
      Location:92 → 112
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001369117.1 → NP_001356046.1  zinc finger protein 618 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL691431, AL691496
      Conserved Domains (1) summary
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001369118.1 → NP_001356047.1  zinc finger protein 618 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes isoform h.
      Source sequence(s)
      AL691431, AL691496
      Conserved Domains (1) summary
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001369119.1 → NP_001356048.1  zinc finger protein 618 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variant 8, encodes isoform h.
      Source sequence(s)
      AL691431, AL691496
      Conserved Domains (1) summary
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_028326.2 → NP_082602.1  zinc finger protein 618 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL691431, AL691496
      Consensus CDS
      CCDS51203.1
      UniProtKB/TrEMBL
      F8WIU3
      Related
      ENSMUSP00000069275.6, ENSMUST00000064814.6
      Conserved Domains (1) summary
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_028327.1 → NP_082603.1  zinc finger protein 618 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AL691431, AL691496
      Consensus CDS
      CCDS89760.1
      UniProtKB/Swiss-Prot
      Q69Z57, Q80YY7, Q80YY8, Q9CZ99
      Related
      ENSMUSP00000103038.2, ENSMUST00000107415.8
      Conserved Domains (1) summary
      sd00017
      Location:148 → 168
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      62883792..63057946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538286.1 → XP_006538349.1  zinc finger protein 618 isoform X18

      See identical proteins and their annotated locations for XP_006538349.1

      Conserved Domains (2) summary
      sd00017
      Location:92 → 112
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:839 → 919
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    2. XM_006538288.1 → XP_006538351.1  zinc finger protein 618 isoform X19

      Conserved Domains (2) summary
      sd00017
      Location:92 → 112
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:831 → 911
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    3. XM_030253817.1 → XP_030109677.1  zinc finger protein 618 isoform X20

      Conserved Domains (2) summary
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:807 → 887
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    4. XM_030253818.1 → XP_030109678.1  zinc finger protein 618 isoform X21

      Conserved Domains (2) summary
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:799 → 879
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    5. XM_030253814.1 → XP_030109674.1  zinc finger protein 618 isoform X12

      Conserved Domains (2) summary
      sd00017
      Location:148 → 168
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:895 → 975
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    6. XM_030253815.1 → XP_030109675.1  zinc finger protein 618 isoform X13

      Conserved Domains (2) summary
      sd00017
      Location:148 → 168
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:887 → 967
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    7. XM_036164467.1 → XP_036020360.1  zinc finger protein 618 isoform X14

      Conserved Domains (1) summary
      sd00017
      Location:148 → 168
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_036164468.1 → XP_036020361.1  zinc finger protein 618 isoform X15

      Conserved Domains (1) summary
      sd00017
      Location:148 → 168
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_030253816.1 → XP_030109676.1  zinc finger protein 618 isoform X16

      Conserved Domains (2) summary
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:863 → 943
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    10. XM_036164469.1 → XP_036020362.1  zinc finger protein 618 isoform X17

      Conserved Domains (1) summary
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. XM_006538287.3 → XP_006538350.1  zinc finger protein 618 isoform X18

      See identical proteins and their annotated locations for XP_006538350.1

      Conserved Domains (2) summary
      sd00017
      Location:92 → 112
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:839 → 919
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    12. XM_006538279.3 → XP_006538342.2  zinc finger protein 618 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:891 → 971
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    13. XM_006538282.3 → XP_006538345.2  zinc finger protein 618 isoform X4

      Conserved Domains (2) summary
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:876 → 956
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    14. XM_006538280.3 → XP_006538343.2  zinc finger protein 618 isoform X2

      Conserved Domains (2) summary
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:890 → 970
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    15. XM_030253812.1 → XP_030109672.1  zinc finger protein 618 isoform X5

      Conserved Domains (2) summary
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:875 → 955
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    16. XM_006538281.3 → XP_006538344.2  zinc finger protein 618 isoform X3

      Conserved Domains (2) summary
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:883 → 963
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    17. XM_017320394.2 → XP_017175883.1  zinc finger protein 618 isoform X6

      Conserved Domains (2) summary
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:868 → 948
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    18. XM_030253813.1 → XP_030109673.1  zinc finger protein 618 isoform X7

      Conserved Domains (2) summary
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:867 → 947
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    19. XM_006538283.3 → XP_006538346.2  zinc finger protein 618 isoform X8

      Conserved Domains (2) summary
      sd00017
      Location:112 → 132
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:859 → 939
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    20. XM_006538284.3 → XP_006538347.2  zinc finger protein 618 isoform X9

      Conserved Domains (2) summary
      sd00017
      Location:112 → 132
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:851 → 931
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    21. XM_006538291.3 → XP_006538354.2  zinc finger protein 618 isoform X10

      Conserved Domains (2) summary
      sd00017
      Location:112 → 132
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:836 → 916
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    22. XM_017320395.2 → XP_017175884.1  zinc finger protein 618 isoform X11

      Conserved Domains (2) summary
      sd00017
      Location:112 → 132
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05699
      Location:835 → 915
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    23. XM_006538289.1 → XP_006538352.1  zinc finger protein 618 isoform X22

    RNA

    1. XR_003955017.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YY7.3 GenPept UniProtKB/Swiss-Prot:Q80YY7

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