U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Tbccd1 TBCC domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 70573, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tbccd1provided by MGI
    Official Full Name
    TBCC domain containing 1provided by MGI
    Primary source
    MGI:MGI:1917823
    See related
    Ensembl:ENSMUSG00000004462 AllianceGenome:MGI:1917823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730478M09Rik
    Summary
    Predicted to be involved in several processes, including maintenance of Golgi location; maintenance of centrosome location; and regulation of cell shape. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in spindle pole centrosome. Is expressed in liver; pancreas; and retina. Orthologous to human TBCCD1 (TBCC domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 8.7), liver E14 (RPKM 7.8) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    16 B1; 16 13.67 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22631964..22676441, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22813214..22857695, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene Neighboring gene predicted gene, 30416 Neighboring gene crystallin, gamma S Neighboring gene STARR-positive B cell enhancer ABC_E484 Neighboring gene DnaJ heat shock protein family (Hsp40) member B11 Neighboring gene predicted gene, 30505 Neighboring gene alpha-2-HS-glycoprotein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. Jiang D, et al. J Comp Neurol, 2020 Apr 1. PMID 31609468, Free PMC Article
    2. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    3. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of Golgi location IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of Golgi location ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of centrosome location IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of centrosome location ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    TBCC domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081368.2 → NP_001074837.1  TBCC domain-containing protein 1

      See identical proteins and their annotated locations for NP_001074837.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC079629, BC082558, CF749564, CT027991
      Consensus CDS
      CCDS49798.1
      UniProtKB/Swiss-Prot
      Q640P7, Q68FM1, Q8CA17, Q9CYG4
      Related
      ENSMUSP00000004576.7, ENSMUST00000004576.8
      Conserved Domains (1) summary
      pfam07986
      Location:332 → 444
      TBCC; Tubulin binding cofactor C

    2. NM_001316746.1 → NP_001303675.1  TBCC domain-containing protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK039905, BC079629, BC082558, CF749564, CT027991
      Consensus CDS
      CCDS49798.1
      UniProtKB/Swiss-Prot
      Q640P7, Q68FM1, Q8CA17, Q9CYG4
      Related
      ENSMUSP00000156210.2, ENSMUST00000232075.2
      Conserved Domains (1) summary
      pfam07986
      Location:332 → 444
      TBCC; Tubulin binding cofactor C

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      22631964..22676441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522564.3 → XP_006522627.1  TBCC domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam07986
      Location:377 → 489
      TBCC; Tubulin binding cofactor C

    2. XM_006522566.5 → XP_006522629.1  TBCC domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      pfam07986
      Location:355 → 467
      TBCC; Tubulin binding cofactor C

    3. XM_006522568.4 → XP_006522631.1  TBCC domain-containing protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006522631.1

      UniProtKB/Swiss-Prot
      Q640P7, Q68FM1, Q8CA17, Q9CYG4
      Conserved Domains (1) summary
      pfam07986
      Location:332 → 444
      TBCC; Tubulin binding cofactor C

    4. XM_006522567.5 → XP_006522630.1  TBCC domain-containing protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006522630.1

      UniProtKB/Swiss-Prot
      Q640P7, Q68FM1, Q8CA17, Q9CYG4
      Conserved Domains (1) summary
      pfam07986
      Location:332 → 444
      TBCC; Tubulin binding cofactor C

    5. XM_006522569.3 → XP_006522632.1  TBCC domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A338P6P9
      Related
      ENSMUSP00000156050.2, ENSMUST00000232345.2

    RNA

    1. XR_004939221.1 RNA Sequence

    2. XR_003951832.2 RNA Sequence

    3. XR_003951830.2 RNA Sequence

    4. XR_003951831.2 RNA Sequence

    5. XR_384598.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q640P7.1 GenPept UniProtKB/Swiss-Prot:Q640P7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous