Bst2 bone marrow stromal cell antigen 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bst2provided by MGI
Official Full Name: bone marrow stromal cell antigen 2provided by MGI
Primary source: MGI:MGI:1916800
See related: Ensembl:ENSMUSG00000046718 AllianceGenome:MGI:1916800
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GREG; Bst-2; CD317; DAMP-1; 2310015I10Rik
Summary: Predicted to enable metalloendopeptidase inhibitor activity and protein homodimerization activity. Involved in several processes, including negative regulation of intracellular transport of viral material; negative regulation of viral genome replication; and response to interferon-gamma. Located in cell surface. Is expressed in retina. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and endometrial cancer. Orthologous to human BST2 (bone marrow stromal cell antigen 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 548.4), liver adult (RPKM 286.5) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.43 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71986899..71990116, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (71534255..71537472, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Promotion of BST2 expression by the transcription factor IRF6 affects the progression of endometriosis.
Title: Promotion of BST2 expression by the transcription factor IRF6 affects the progression of endometriosis.
The roles of BST-2 in murine B cell development and on virus propagation.
Title: The roles of BST-2 in murine B cell development and on virus propagation.
BST2, a Novel Inhibitory Receptor, Is Involved in NK Cell Cytotoxicity through Its Cytoplasmic Tail Domain.
Title: BST2, a Novel Inhibitory Receptor, Is Involved in NK Cell Cytotoxicity through Its Cytoplasmic Tail Domain.
Murine BST2/tetherin promotes measles virus infection of neurons.
Title: Murine BST2/tetherin promotes measles virus infection of neurons.
Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2.
Title: Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2.
CD317 puts the brakes on dendritic cell trafficking to the CNS.
Title: CD317 puts the brakes on dendritic cell trafficking to the CNS.
BST-2/Tetherin is involved in BAFF-enhanced proliferation and survival via canonical NF-kappaB signaling in neoplastic B-lymphoid cells.
Title: BST-2/Tetherin is involved in BAFF-enhanced proliferation and survival via canonical NF-κB signaling in neoplastic B-lymphoid cells.
contain the spread of herpes simplex virus type 1 in vivo, STING-dependent signaling leads to the upregulation of tetherin, a viral restriction factor
Title: A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin.
Tetherin-mediated retention of R-defective virions on the cell surface could enhance syncytium formation.
Title: Mouse tetherin enhances moloney murine leukemia virus-induced syncytium formation.
Bone marrow stromal antigen 2-mediated dendritic cell activation as a critical mechanism for how Tetherin influenced retrovirus cell-mediated immune responses that subsequently inhibited retrovirus replication in vivo.
Title: Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular transport of viral material	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of intracellular transport of viral material	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intracellular transport of viral material	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of plasmacytoid dendritic cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-alpha	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
colocalizes_with cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bone marrow stromal antigen 2

Names: DAMP-1 protein homolog; HM1.24 antigen; tetherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.