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    FHIT fragile histidine triad diadenosine triphosphatase [ Bos taurus (cattle) ]

    Gene ID: 692183, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FHITprovided by VGNC
    Official Full Name
    fragile histidine triad diadenosine triphosphataseprovided by VGNC
    Primary source
    VGNC:VGNC:28998
    See related
    BGD:BT13528; Ensembl:ENSBTAG00000014418
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (40107030..41631056)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343468 Neighboring gene uncharacterized LOC112443454 Neighboring gene uncharacterized LOC132343538 Neighboring gene uncharacterized LOC132343505 Neighboring gene uncharacterized LOC112443500 Neighboring gene uncharacterized LOC132343506

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of eight InDel variants in FHIT on milk traits in Xinjiang brown cattle. Ju X, et al. Anim Biotechnol, 2021 Aug. PMID 32401148
    2. Molecular analysis of the fragile histidine triad (FHIT) tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria (CEH). Guidi E, et al. Cytogenet Genome Res, 2008. PMID 18467844
    3. Comparative genomic mapping of the bovine Fragile Histidine Triad (FHIT) tumour suppressor gene: characterization of a 2 Mb BAC contig covering the locus, complete annotation of the gene, analysis of cDNA and of physiological expression profiles. Uboldi C, et al. BMC Genomics, 2006 May 23. PMID 16719907, Free PMC Article
    4. Comparative mapping of the fragile histidine triad (FHIT) gene in cattle, river buffalo, sheep and goat by FISH and assignment to BTA22 by RH-mapping: a comparison with HSA3. Di Meo GP, et al. Anim Genet, 2005 Aug. PMID 16026356
    5. Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance. Sugimoto M, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16611727, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of eight InDel variants in FHIT on milk traits in Xinjiang brown cattle.
      Title: Effects of eight InDel variants in FHIT on milk traits in Xinjiang brown cattle.
    2. the same mRNA isoforms of FHIT were detected in bladder tumors and in healthy tissues, including a novel isoform that was found in this study, suggesting that epigenetic modifications and altered expression profiles are not a hallmark of vesical tumors
      Title: Molecular analysis of the fragile histidine triad (FHIT) tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria (CEH).
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables bis(5'-adenosyl)-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diadenosine triphosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in purine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bis(5'-adenosyl)-triphosphatase
    Names
    AP3A hydrolase
    AP3Aase
    adenosine 5'-monophosphoramidase FHIT
    adenylylsulfatase
    adenylylsulfate-ammonia adenylyltransferase
    diadenosine 5',5'''-P1,P3-triphosphate hydrolase
    dinucleosidetriphosphatase
    fragile histidine triad protein
    NP_001035736.1
    XP_024838827.1
    XP_024838828.1
    XP_024838829.1
    XP_024838830.1
    XP_024838831.1
    XP_059735890.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040646.1 → NP_001035736.1  bis(5'-adenosyl)-triphosphatase

      See identical proteins and their annotated locations for NP_001035736.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ310181
      UniProtKB/Swiss-Prot
      A6QLK1, Q1KZG4, Q1KZS9
      Conserved Domains (1) summary
      cd01275
      Location:5 → 124
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40107030..41631056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024983061.2 → XP_024838829.1  bis(5'-adenosyl)-triphosphatase isoform X1

      UniProtKB/Swiss-Prot
      A6QLK1, Q1KZG4, Q1KZS9
      Conserved Domains (1) summary
      cd01275
      Location:5 → 124
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

    2. XM_024983062.2 → XP_024838830.1  bis(5'-adenosyl)-triphosphatase isoform X1

      UniProtKB/Swiss-Prot
      A6QLK1, Q1KZG4, Q1KZS9
      Conserved Domains (1) summary
      cd01275
      Location:5 → 124
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

    3. XM_024983060.2 → XP_024838828.1  bis(5'-adenosyl)-triphosphatase isoform X1

      UniProtKB/Swiss-Prot
      A6QLK1, Q1KZG4, Q1KZS9
      Conserved Domains (1) summary
      cd01275
      Location:5 → 124
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

    4. XM_024983059.2 → XP_024838827.1  bis(5'-adenosyl)-triphosphatase isoform X1

      UniProtKB/Swiss-Prot
      A6QLK1, Q1KZG4, Q1KZS9
      Conserved Domains (1) summary
      cd01275
      Location:5 → 124
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

    5. XM_024983063.2 → XP_024838831.1  bis(5'-adenosyl)-triphosphatase isoform X1

      UniProtKB/Swiss-Prot
      A6QLK1, Q1KZG4, Q1KZS9
      Conserved Domains (1) summary
      cd01275
      Location:5 → 124
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

    6. XM_059879907.1 → XP_059735890.1  bis(5'-adenosyl)-triphosphatase isoform X1

      UniProtKB/Swiss-Prot
      A6QLK1, Q1KZG4, Q1KZS9
      Related
      ENSBTAP00000086918.1, ENSBTAT00000135099.1

    RNA

    1. XR_009492299.1 RNA Sequence

    2. XR_009492298.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1KZG4.1 GenPept UniProtKB/Swiss-Prot:Q1KZG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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